Efficacy of tocilizumab for interstitial lung disease associated with polyarticular juvenile idiopathic arthritis

2021 ◽  
Author(s):  
Yuta Maruyama ◽  
Tomonari Shigemura ◽  
Norimoto Kobayashi ◽  
Yozo Nakazawa
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Polyarticular Juvenile Idiopathic Arthritis

scholarly journals Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Koichi Sugihara ◽  
Risa Wakiya ◽  
Hiromi Shimada ◽  
Mikiya Kato ◽  
Tomohiro Kameda ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Case Report ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Female Patient ◽  
Interleukin 6 ◽  
Subcutaneous Administration ◽  
Glucocorticoid Therapy ◽  
Polyarticular Juvenile Idiopathic Arthritis ◽  
Case Presentation

Abstract Background Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizumab infusion in a patient with JIA. Case presentation A 14-year-old female patient with polyarticular JIA developed interstitial lung disease after intravenous and subcutaneous administration of tocilizumab. Her condition improved with glucocorticoid therapy. Conclusion Our results suggest that increased interleukin-6 levels in the blood following tocilizumab treatment may be linked to development of interstitial lung disease.

scholarly journals Type 1 interferonopathy presenting as juvenile idiopathic arthritis with interstitial lung disease: report of a new phenotype

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
S. L. N. Clarke ◽  
L. Robertson ◽  
G. I. Rice ◽  
L. Seabra ◽  
T. N. Hilliard ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Interstitial Lung Disease ◽  
Lung Disease

Cellular mechanisms of interstitial lung disease in children caused by mutations of the ABCA3-transporter

Pneumologie ◽  
2010 ◽  
Vol 64 (01) ◽  
Author(s):  
N Weichert ◽  
E Kaltenborn ◽  
A Hector ◽  
M Woischnik ◽  
S Moslavac ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Cellular Mechanisms
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