Brain‐type natriuretic peptide level in pregnant women with congenital heart disease predicts SGA offspring

2019 ◽  
Vol 61 (12) ◽  
pp. 1221-1226
Author(s):  
Shuji Ishida ◽  
Atsushi Uchiyama ◽  
Ken Imai ◽  
Satoshi Kusuda
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pregnant Women ◽  
Natriuretic Peptide ◽  
Congenital Heart ◽  
Natriuretic Peptide Level ◽  
Peptide Level

scholarly journals EXPRESS: Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: Lessons Learnt from the Large Turkish Nationwide Registry (THALES)

2021 ◽  
pp. 204589402110242
Author(s):  
Serdar Mehmet Kücükoglu ◽  
cihangir kaymaz ◽  
Dursun Alehan ◽  
Serdar Kula ◽  
Atıf Akcevin ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Congenital Heart ◽  
Natriuretic Peptide Level ◽  
Eisenmenger’S Syndrome ◽  
Peptide Level ◽  
Pulmonary Arterial

Pulmonary hypertension is a group of diseases, including pulmonary arterial hypertension associated with congenital heart disease (APAH-CHD), characterized by progressive deterioration in pulmonary hemodynamics associated with substantial morbidity and mortality risk. THALES is a national multicenter, prospective observational registry, providing data on patients with APAH-CHD. The study comprised APAH-CHD patients (>3 months of age) with confirmed diagnosis of right heart catheterization or echocardiographic findings. Initial and follow-up data were collected via regular hospital visits. Descriptive statistics are used for definitive purposes. Overall, 1,034 patients aged 3 months–79 years (median 11.2 [Q1–Q3: 2.2–24.3] years) with APAH-CHD were enrolled at 61 centers, 50.3% being retrospectively enrolled. Most had either Eisenmenger's syndrome (49.2%) or systemic-to-pulmonary shunts (42.7%). Patients were mostly in functional class I–II at the time of diagnosis (46.6%). Mean 6-minute walk distance (6MWD) was 369±120 m. Mean pulmonary arterial pressure was 54.7±22.2 mmHg for the whole group, and was highest in patients with Eisenmenger's syndrome. Targeted therapies were noted in 398 (38.5%) patients (monotherapy in 80.4%). Follow-up data was available in 506 patients. Survival at 140 months was 79% and was associated with baseline 6MWD >440 m (p=0.009), brain natriuretic peptide level <300 ng/L (p <0.001). Follow-up 6MWD >165 m (p <0.0001), brain natriuretic peptide level <300 ng/L (p=0.031), and targeted therapies (p=0.004) were also predictive of survival. THALES is the largest registry dedicated to APAH-CHD to date and provides important contributions on demographics, clinical characteristics, and gaps in disease management.

scholarly journals N-terminal pro-B-type natriuretic peptide predicts cardiovascular complications in pregnant women with congenital heart disease

2013 ◽  
Vol 35 (11) ◽  
pp. 708-715 ◽  
Author(s):  
M. A. M. Kampman ◽  
A. Balci ◽  
D. J. van Veldhuisen ◽  
A. P. J. van Dijk ◽  
J. W. Roos-Hesselink ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pregnant Women ◽  
Natriuretic Peptide ◽  
Congenital Heart ◽  
Cardiovascular Complications

scholarly journals Early N-terminal pro-B-type natriuretic peptide is associated with cardiac complications and function during pregnancy in congenital heart disease

2021 ◽  
Vol 29 (5) ◽  
pp. 262-272
Author(s):  
A. S. Siegmund ◽  
P. G. Pieper ◽  
B. J. Bouma ◽  
F. M. Rosenberg ◽  
H. Groen ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pregnant Women ◽  
Ventricular Function ◽  
Natriuretic Peptide ◽  
Predictive Value ◽  
Congenital Heart ◽  
First Trimester ◽  
National Study ◽  
In Pregnancy

Abstract Background Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels at 20 weeks’ gestation predict adverse cardiovascular (CV) complications during pregnancy in women with congenital heart disease (CHD). To improve early risk assessment in these women, we investigated the predictive value of first-trimester NT-proBNP for CV complications and its association with ventricular function during pregnancy. Methods Pregnant women with CHD, previously enrolled in a prospective national study or evaluated by an identical protocol, were included. Clinical data, echocardiographic evaluation and NT-proBNP measurements were obtained at 12, 20 and 32 weeks’ gestation. Elevated NT-proBNP was defined as > 235 pg/ml (95th percentile reference value of healthy pregnant women in the literature). Results We examined 126 females (mean age 29 years). Elevated NT-proBNP at 12 weeks was associated with CV complications (n = 7, 5.6%, odds ratio 10.9, p = 0.004). Arrhythmias were the most common complication (71%). The negative predictive value of low NT-proBNP to exclude CV complications was 97.2%. In women with CV complications, NT-proBNP levels remained high throughout pregnancy, while a decrease was seen in women without CV complications (p < 0.001 for interaction between group and time). At 12 weeks, higher NT-proBNP levels were associated with impaired subpulmonary ventricular function (p < 0.001) and also with a decline in subpulmonary ventricular function later in pregnancy (p = 0.012). Conclusions In this study, first-trimester NT-proBNP levels were associated with adverse CV complications and a decline in subpulmonary ventricular function later in pregnancy in women with CHD. Early NT-proBNP evaluation is useful for tailored care in pregnant women with CHD.

scholarly journals Accuracy of risk prediction scores in pregnant women with congenital heart disease

2019 ◽  
Vol 14 (3) ◽  
pp. 470-478 ◽  
Author(s):  
Yuli Y. Kim ◽  
Leah A. Goldberg ◽  
Katherine Awh ◽  
Tanmay Bhamare ◽  
David Drajpuch ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pregnant Women ◽  
Risk Prediction ◽  
Congenital Heart

scholarly journals MORTALITY IN PREGNANT WOMEN WITH CONGENITAL HEART DISEASE: A SUBANALYSIS OF THE CALIFORNIA PREGNANCY-ASSOCIATED MORTALITY REVIEW

2017 ◽  
Vol 69 (11) ◽  
pp. 606
Author(s):  
Aarthi Sabanayagam ◽  
Anushree Agarwal ◽  
Christy MacCain ◽  
Elizabeth Lawton ◽  
Elliot Main ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pregnant Women ◽  
Congenital Heart ◽  
Mortality Review

1346: Health behaviour of pregnant women with congenital heart disease

2007 ◽  
Vol 6 (1_suppl) ◽  
pp. 27-28
Author(s):  
Philip Moons ◽  
Els Costermans ◽  
Els Huyghe ◽  
Wim Drenthen ◽  
Petronella Pieper ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pregnant Women ◽  
Health Behaviour ◽  
Congenital Heart

Plasma B-type natriuretic peptide in congenital heart disease

2015 ◽  
Vol 33 (11) ◽  
pp. 1701
Author(s):  
Sevket Balta ◽  
Ali Osman Yildirim ◽  
Mustafa Demir ◽  
Cengiz Ozturk ◽  
Mustafa Aparci ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Natriuretic Peptide ◽  
Congenital Heart
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