Prognostic factors of congenital diaphragmatic hernia accompanied by cardiovascular malformation

2013 ◽  
Vol 55 (4) ◽  
pp. 492-497 ◽  
Author(s):  
Shigehiro Takahashi ◽  
Haruhiko Sago ◽  
Yutaka Kanamori ◽  
Masahiro Hayakawa ◽  
Hiroomi Okuyama ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Cardiovascular Malformation

Congenital diaphragmatic hernia: antenatal prognostic factors

1997 ◽  
Vol 23 (10) ◽  
pp. 1062-1069 ◽  
Author(s):  
B. Thébaud ◽  
A. Azancot ◽  
P. de Lagausie ◽  
E. Vuillard ◽  
L. Ferkadji ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia

Perinatal outcome and prognostic factors in prenatally diagnosed congenital diaphragmatic hernia

1998 ◽  
Vol 12 (2) ◽  
pp. 107-111 ◽  
Author(s):  
M. P. Geary ◽  
L. S. Chitty ◽  
J. J. Morrison ◽  
V. Wright ◽  
A. Pierro ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Perinatal Outcome

scholarly journals Natural courses and prognostic factors of pulmonary underdevelopment except for congenital diaphragmatic hernia

2020 ◽  
Vol 8 (4) ◽  
pp. 206
Author(s):  
Min Soo Kim ◽  
Yun Jung Choi ◽  
Seunghyun Lee ◽  
Woo Sun Kim ◽  
Dong In Suh ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia

scholarly journals Analysis of prognostic factors in congenital diaphragmatic hernia in neonates

2019 ◽  
Vol 24 (3) ◽  
pp. 176
Author(s):  
Jenisha Chaudhary ◽  
B Shivprasad ◽  
V Lakshmi ◽  
R Shanmughsundaram ◽  
G Nandhini ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia

scholarly journals Prognostic factors of death in children during the first year of life due to congenital diaphragmatic hernia: analysis of a hospital cohort from 2005 to 2015

2020 ◽  
Vol 96 (5) ◽  
pp. 569-575 ◽  
Author(s):  
Roberta Ivanira Silva do Carmo ◽  
Fernando Maia Peixoto-Filho ◽  
Arnaldo Bueno ◽  
Marlon Fonseca ◽  
Saint Clair dos Santos Gomes Junior
Keyword(s):  
Prognostic Factors ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
First Year ◽  
First Year Of Life

scholarly journals Congenital Diaphragmatic Hernia – Analysis of Possible Prognostic Factors Predicting the Outcome

2017 ◽  
Vol 17 (2) ◽  
pp. 25-28
Author(s):  
Iveta Racko ◽  
Ieva Karklina-Kravale ◽  
Zane Abola ◽  
Ilze Meldere
Keyword(s):  
Prognostic Factors ◽  
Congenital Diaphragmatic Hernia ◽  
Surgical Therapy ◽  
Diaphragmatic Hernia ◽  
Apgar Score ◽  
Blood Gases ◽  
Time Interval ◽  
Early Intubation ◽  
The Mean ◽  
Initial Blood

Abstract Introduction. Congenital diaphragmatic hernia (CDH) - a relatively rare developmental defect due to a failure of pleuroperitoneal canal closure. The size of the defect between abdominal and thoracic cavities may be variable and it may have a significant impact on the clinical manifestation and prognosis. In this study we set out additional factors to determine if they affect the outcome of the newborns with CDH. Aim of the Study. To investigate and analyze the influence of selected postnatal prognostic factors for predicting the outcome. The primary outcome measure was survival. Material and methods. The present study is retrospective including the data collection and analysis of medical documentation of patients born with CDH and treated in the Children’s Clinical University hospital between 2012 and 2017. The selected prognostic factors included antenatal diagnostics, Apgar score at 1' and 5', need for an early intubation (≤ 3 h after birth), initial blood gases in first 24 h of life, time interval between delivery and surgical therapy, the stomach and liver presence in the thorax, additional congenital abnormalities, a type and duration of invasive ventilatory support. Outcome parameters were compared between survivors (S) and non-survivors (NS). Results. 19 patients (pts) were identified - 14 S and 5 NS. Total mortality rate - 26%. 17/19 had left-sided, 2/19 - right-sided CDH. 17/19 pregnancies were monitored, prenatal diagnosis was made in 8 pts - 3 of them NS. The mean Apgar score at 1’ in S group was 5,5, NS - 5,0. At 5’ - 6,7 and 5,6. Need for an early intubation was 64% for S, 100% - NS. Initial blood gases in S (n=11) and NS (n=5) showed the mean pH value of 7,18 and 7,02. Mean PaCO2 - 62,92 and 77,42 mm Hg. 16/19 underwent the operation. 2 pts died before and 3 after surgical therapy. The average time interval between delivery and surgical therapy in S group was 31,6 hours, NS - 73,7 h. The intrathoracic liver was observed in 3 pts, 2 of them died, the intrathoracic stomach - 2, none of them died. 14/16 pts had a primary surgical repair (PR), 2/16 - Silo closure before total repair. 6 pts had additional congenital defects - 2/14 S and 4/5 NS. 5 out of all 6 had cardiac anomalies. The average required conventional ventilation time in S (n=9) was 175,9 h, NS (n=3) - 25,7 h. High-frequency oscillatory ventilation for S (n=6) was applied for 255 h, NS (n=5) 157,3 h. The results showed statistically significant relationship between the outcome and additional abnormalities (r(17)=.623, p=0.017) and time interval between delivery and surgical therapy (r(11)=.768, p=.014). Conclusions. The possible predictors of outcome were additional abnormalities and time interval between delivery and surgical therapy.

scholarly journals Early population-based outcomes of infants born with congenital diaphragmatic hernia

2018 ◽  
Vol 103 (6) ◽  
pp. F517-F522 ◽  
Author(s):  
Anna-May Long ◽  
Kathryn J Bunch ◽  
Marian Knight ◽  
Jennifer J Kurinczuk ◽  
Paul D Losty
Keyword(s):  
Prognostic Factors ◽  
Prenatal Diagnosis ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Population Based ◽  
International Studies ◽  
Factors Associated ◽  
Female Sex ◽  
Pulmonary Vasodilators ◽  
The Uk

PurposeThis study aims to describe short-term outcomes of live-born infants with congenital diaphragmatic hernia (CDH) and to identify prognostic factors associated with early mortality.DesignA prospective population cohort study was undertaken between April 2009 and September 2010, collecting data on live-born infants with CDH from all 28 paediatric surgical centres in the UK and Ireland using an established surgical surveillance system. Management and outcomes are described. Prognostic factors associated with death before surgery are explored.ResultsTwo hundred and nineteen live-born infants with CDH were reported within the data collection period. There were 1.5 times more boys than girls (n=133, 61%). Thirty-five infants (16%) died without an operation. This adverse outcome was associated with female sex (adjusted OR (aOR) 3.96, 95% CI 1.66 to 9.47), prenatal diagnosis (aOR 4.99, 95% CI 1.31 to 18.98), and the need for physiological support in the form of inotropes (aOR 9.96, 95% CI 1.19 to 83.25) or pulmonary vasodilators (aOR 4.09, 95% CI 1.53 to 10.93). Significant variation in practice existed among centres, and some therapies potentially detrimental to infant outcomes were used, including pulmonary surfactant in 45 antenatally diagnosed infants (34%). Utilisation of extracorporeal membrane oxygenation was very low compared with published international studies (n=9/219, 4%). Postoperative 30-day survival was 98% for 182 infants with CDH who were adequately physiologically stabilised and underwent surgery.ConclusionThis is the first British Isles population-based study reporting outcome metrics for infants born with CDH. 16% of babies did not survive to undergo surgery. Factors associated with poor outcome included female sex and prenatal diagnosis. Early postoperative survival in those who underwent surgical repair was excellent.

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