Link between childhood tobacco exposure and childhood psoriasis: A case‐control study

2021 ◽  
Author(s):  
Mehmet Fatih Atak ◽  
Nihal Kundakci ◽  
Banu Farabi
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Tobacco Exposure ◽  
Control Study

Association of MTHFD Gene Polymorphisms and Maternal Smoking With Risk of Congenital Heart Disease: A Hospital-Based Case-Control Study

2021 ◽  
Author(s):  
Xinli Song ◽  
Qiongxuan Li ◽  
Jingyi Diao ◽  
Jinqi Li ◽  
Yihuan Li ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Maternal Smoking ◽  
Congenital Heart ◽  
Case Control Study ◽  
Interaction Effects ◽  
Case Control ◽  
Tobacco Exposure ◽  
Maternal Tobacco Exposure ◽  
Control Study

Abstract Background: MTHFD may affect the embryonic development by elevated homocysteine levels, DNA synthesis and DNA methylation, but limited number of genetic variants of MTHFD was focused on the association with congenital heart disease (CHD). This study examined the role of MTHFD and maternal smoking in CHD risk, and investigated their interaction effects in Chinese populations. Methods: A case-control study of 464 mothers of CHD infants and 504 mothers of health controls was performed. The exposures of interest were maternal tobacco exposure, single nucleotide polymorphisms (SNPs) of maternal MTHFD gene. The logistic regression model was used for accessing the strength of association.Results: Mothers exposed to secondhand smoke during three months before pregnancy (adjusted odds ratio [aOR] = 1.56; 95% confidence interval [CI]: 1.13-2.15) and in the first trimester of pregnancy (aOR = 2.24; 95%CI: 1.57-3.20) were observed an increased risk of CHD. Our study also found that polymorphisms of maternal MTHFD gene at rs1950902 (AA vs. GG: aOR = 1.73, 95% CI: 1.01-2.97), rs2236222 (GG vs. AA: aOR = 2.38, 95% CI: 1.38-4.12), rs1256142 (GA vs.GG: aOR = 1.57, 95% CI: 1.01-2.45) and rs11849530 (GG vs. AA: aOR = 1.68, 95% CI: 1.02-2.77) were significantly associated with higher risk of CHD. Furthermore, we found the different degrees of interaction effects between polymorphisms of the MTHFD gene including rs1950902, rs2236222, rs1256142, rs11849530 and rs2236225, and maternal tobacco exposure.Conclusions: Maternal polymorphisms of MTHFD gene at rs1950902, rs2236222, rs1256142 and rs11849530, maternal tobacco exposure and their interactions are significantly increased the risk of CHD in offspring. However, more studies in different ethnic populations with a larger sample and prospective designs are required to confirm our findings.Trial registration: Registration number: ChiCTR1800016635; http://www.chictr.org.cn/edit.aspx?pid=28300&htm=4

Risk of bladder cancer by source and type of tobacco exposure: A case-control study

1989 ◽  
Vol 44 (4) ◽  
pp. 622-628 ◽  
Author(s):  
J. D. Burch ◽  
T. E. Rohan ◽  
G. R. Howe ◽  
H. A. Risch ◽  
G. B. Hill ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Tobacco Exposure ◽  
Control Study

Precursor lesions of gastric polyps developing during maintenance omeprazole. A case-control study

2001 ◽  
Vol 120 (5) ◽  
pp. A657-A658
Author(s):  
A CATS ◽  
E BLOEMENA ◽  
E SCHENK ◽  
I CLINICS ◽  
S MEUWISSEN ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Precursor Lesions ◽  
Gastric Polyps ◽  
Control Study

Risk factors for esophageal adenocarcinoma: A case-control study

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
B AVIDAN ◽  
A SONNENBERG ◽  
T SCHNELL ◽  
G CHEJFEC ◽  
A METZ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Adenocarcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

130: A Case-Control Study of Medical Co-Morbidities in Women with Interstitial Cystitis

2007 ◽  
Vol 177 (4S) ◽  
pp. 45-45
Author(s):  
J. Quentin Clemens ◽  
Richard T. Meenan ◽  
Maureen C. O’Keeffe Rosetti ◽  
Teresa M. Kimes ◽  
Elizabeth A. Calhoun
Keyword(s):  
Interstitial Cystitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document