Anaphylaxis and epinephrine autoinjector use in pediatric patients with cutaneous mastocytosis

Serum Tryptase Levels in 114 Pediatric Patients with Cutaneous Mastocytosis

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2017.12.287 ◽

2018 ◽

Vol 141 (2) ◽

pp. AB89

Author(s):

Neha Seth ◽

Javier Chinen ◽

Maria G. Buheis ◽

Audrey J. Chan ◽

Raegan D. Hunt ◽

...

Keyword(s):

Pediatric Patients ◽

Serum Tryptase ◽

Cutaneous Mastocytosis

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Mediator-Related Symptoms and Anaphylaxis in Children with Mastocytosis

10.20944/preprints202102.0015.v1 ◽

2021 ◽

Author(s):

Knut Brockow ◽

Katarzyna Plata-Nazar ◽

Magdalena Lange ◽

Bogusław Nedoszytko ◽

Marek Niedoszytko ◽

...

Keyword(s):

Pediatric Patients ◽

Clinical Symptoms ◽

Systemic Mastocytosis ◽

Skin Lesions ◽

Physical Factors ◽

Complement Components ◽

Physical Effort ◽

Typical Finding ◽

Vibration Stress ◽

Cutaneous Mastocytosis

Mastocytosis is characterized by pathological accumulation of mast cells (MC) in various organs. In these patients, MC may degranulate and thereby contribute to clinical symptoms, especially when a concomitant allergy is present. However, MC activation can not only be induced by high-affinity receptors for IgE, but also by anaphylatoxins, neuropeptides, IgG immune complexes, complement-components, drugs, products of bacteria or parasites, as well as physical factors such as heat, cold, vibration, stress, sun, or physical effort. Symptoms due to mediators released by activated MC may develop in adults suffering from systemic mastocytosis, but also evolve in children who usually have cutaneous mastocytosis (CM). Clinically, CM is otherwise characterized by typical brown, maculopapular skin lesions or mastocytoma associated with a positive Darier’s sign. Pruritus and flushing are common and blistering may also be recorded, especially in diffuse CM (DCM). Pediatric patients with mastocytosis may also have gastrointestinal, respiratory, and neurologic complaints. Although anaphylaxis is not a typical finding, pediatric patients with massive skin involvement and high tryptase levels have a relatively high risk to develop anaphylaxis. This paper reviews MC mediator-related symptoms and anaphylaxis in children with mastocytosis, with special emphasis on risk factors, triggers, and management.

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Mediator-Related Symptoms and Anaphylaxis in Children with Mastocytosis

International Journal of Molecular Sciences ◽

10.3390/ijms22052684 ◽

2021 ◽

Vol 22 (5) ◽

pp. 2684

Author(s):

Knut Brockow ◽

Katarzyna Plata-Nazar ◽

Magdalena Lange ◽

Bogusław Nedoszytko ◽

Marek Niedoszytko ◽

...

Keyword(s):

Pediatric Patients ◽

Clinical Symptoms ◽

Systemic Mastocytosis ◽

Skin Lesions ◽

Physical Factors ◽

Complement Components ◽

Physical Effort ◽

Typical Finding ◽

Vibration Stress ◽

Cutaneous Mastocytosis

Mastocytosis is characterized by the pathological accumulation of mast cells (MC) in various organs. In these patients, MC may degranulate and thereby contribute to clinical symptoms, especially when a concomitant allergy is present. However, MC activation can not only be induced by high-affinity receptors for IgE, but also by anaphylatoxins, neuropeptides, IgG immune complexes, complement-components, drugs, products of bacteria or parasites, as well as physical factors such as heat, cold, vibration, stress, sun, or physical effort. Symptoms due to mediators released by activated MC may develop in adults suffering from systemic mastocytosis, but also evolve in children who usually have cutaneous mastocytosis (CM). Clinically, CM is otherwise characterized by typical brown, maculopapular skin lesions or mastocytoma associated with a positive Darier’s sign. Pruritus and flushing are common and blistering may also be recorded, especially in diffuse CM (DCM). Pediatric patients with mastocytosis may also have gastrointestinal, respiratory, and neurologic complaints. Although anaphylaxis is not a typical finding, pediatric patients with massive skin involvement and high tryptase levels have a relatively high risk to develop anaphylaxis. This paper reviews MC mediator-related symptoms and anaphylaxis in children with mastocytosis, with special emphasis on risk factors, triggers, and management.

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Assessing vaccination reactions in pediatric patients with maculopapular cutaneous mastocytosis

Pediatric Dermatology ◽

10.1111/pde.14492 ◽

2021 ◽

Author(s):

Maija L. Johansen ◽

Leslie P. Lawley

Keyword(s):

Pediatric Patients ◽

Cutaneous Mastocytosis

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Audiology Service Models in a Family Physician Practice Setting

Perspectives on Audiology ◽

10.1044/poa6.1.24 ◽

2010 ◽

Vol 6 (1) ◽

pp. 24-32 ◽

Cited By ~ 2

Author(s):

Sridhar Krishnamurti

Keyword(s):

Pediatric Patients ◽

Practice Patterns ◽

Healthcare Delivery ◽

Direct Consequence ◽

Direct Access ◽

Practice Setting ◽

Pediatric Populations ◽

Family Practice Physicians ◽

Primary Focus ◽

Balance Problems

This article illustrates the potential of placing audiology services in a family physician’s practice setting to increase referrals of geriatric and pediatric patients to audiologists. The primary focus of family practice physicians is the diagnosis/intervention of critical systemic disorders (e.g., cardiovascular disease, diabetes, cancer). Hence concurrent hearing/balance disorders are likely to be overshadowed in such patients. If audiologists get referrals from these physicians and have direct access to diagnose and manage concurrent hearing/balance problems in these patients, successful audiology practice patterns will emerge, and there will be increased visibility and profitability of audiological services. As a direct consequence, audiological services will move into the mainstream of healthcare delivery, and the profession of audiology will move further towards its goals of early detection and intervention for hearing and balance problems in geriatric and pediatric populations.

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