Hyperpigmented and hypertrichotic sclerotic plaques in a child

2020 ◽  
Vol 37 (5) ◽  
pp. 937-938
Author(s):  
Michael A. Cardis ◽  
Hemalatha Srinivasalu ◽  
Jay Greenberg ◽  
Scott A. Norton
Keyword(s):  
Sclerotic Plaques

Erythematoedematous and Sclerotic Plaques in a Man Receiving Systemic Chemotherapy

2021 ◽  
Author(s):  
Mar Ramírez-Lluch ◽  
Eduardo Bernia ◽  
Onofre Sanmartín-Jiménez
Keyword(s):  
Systemic Chemotherapy ◽  
Sclerotic Plaques

scholarly journals CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Svetlana F. Khaiboullina ◽  
Aigul R. Gumerova ◽  
Irina F. Khafizova ◽  
Ekaterina V. Martynova ◽  
Vincent C. Lombardi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Potential Role ◽  
Serum Levels ◽  
Unknown Etiology ◽  
Serum Cytokine ◽  
Lymphocyte Migration ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Sclerotic Plaques

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of unknown etiology. Leukocyte infiltration of brain tissue and the subsequent inflammation, demyelination, axonal damage, and formation of sclerotic plaques is a hallmark of MS. Upregulation of proinflammatory cytokines has been suggested to play an essential role in regulating lymphocyte migration in MS. Here we present data on serum cytokine expression in MS cases. Increased serum levels of IL-17 and IL-23 were observed, suggesting activation of the Th17 population of immune effector cells. Additionally, increased levels of IL-22 were observed in the serum of those with acute phase MS. Unexpectedly, we observed an upregulation of the serum chemokine CCL27 in newly diagnosed and acute MS cases. CCL27 is an inflammatory chemokine associated with homing of memory T cells to sites of inflammation. Therefore, its upregulation in association with MS suggests a potential role in disease pathogenesis. Our data supports previous reports showing IL-17 and -23 upregulation in association with MS and potentially identify a previously unknown involvement for CCL27.

Phospholipase A2 Modification Enhances Lipoprotein(a) Binding to the Subendothelial Matrix

1998 ◽  
Vol 79 (03) ◽  
pp. 640-648 ◽  
Author(s):  
Alka Khaitan ◽  
Gunther Fless ◽  
Jane Hoover-Plow
Keyword(s):  
Extracellular Matrix ◽  
Phospholipase A2 ◽  
Fold Increase ◽  
Matrix Proteins ◽  
Cell Binding ◽  
Compartment System ◽  
Lipoprotein A ◽  
The Matrix ◽  
Subendothelial Matrix ◽  
Sclerotic Plaques

SummaryLipoprotein(a), Lp(a), is found in the extracellular matrix in athero-sclerotic plaques, but with a different localization than LDL. A two-compartment system, with a monolayer of endothelial cells forming a barrier, was used to compare the transport, cell binding, and retention of Lp(a) and LDL into the subendothelial matrix. Baseline values for transport and retention of Lp(a) and LDL were not significantly different. Incubation with lipoprotein lipase or sphingomyelinase caused modest and similar increases in transport and retention of the two lipo-proteins. In contrast, incubation with phospholipase A2 (PLA2) resulted in a marked (4-fold) increase in retention of Lp(a) on the subendothelial matrix, but a lesser (2-fold) increase in LDL retention. Moreover, PLA2 treatment of Lp(a) enhanced its binding to individual matrix proteins (fibronectin, laminin, or collagen) by 4-10 times above that of LDL. The enzymatic activity of PLA2 was responsible for its effect on Lp(a) binding. The lysine binding sites of Lp(a) contributed to the increased binding of PLA2-modified Lp(a) to the matrix, and the enhanced lysine binding functions of PLA2-modified Lp(a) was demonstrated by two independent approaches. Thus, PLA2 modification leads to enhanced interactions of lipoproteins with the extracellular matrix, and this effect is more pronounced with Lp(a).

scholarly journals Sclerosis and blisters: An uncommon association revealing a new case of bullous morphea

2021 ◽  
Vol 12 (2) ◽  
pp. 167-168
Author(s):  
Soraya Aouali ◽  
Saida Sefraoui ◽  
Kaoutar Sof ◽  
Siham Dikhaye ◽  
Nada Zizi
Keyword(s):  
Case Report ◽  
Rare Variant ◽  
Localized Scleroderma ◽  
Topical Steroids ◽  
Puva Therapy ◽  
Therapeutic Approaches ◽  
The Subject ◽  
Sclerotic Plaques

Bullous morphea is a rare variant of localized scleroderma (morphea) characterized by subepidermal bullae developed over sclerotic plaques. The pathogenesis of bullae formation has been the subject of several debates, which arrived at the conclusion of a multifactorial mechanism. We report the case of a 67-year-old patient with bullous morphea of the trunk and thighs, who showed a good response to PUVA therapy combined with topical steroids. Our case report supports the efficiency of PUVA therapy associated with topical steroids as a safe regimen compared to other therapeutic approaches.

PLATELET ADHESION TO HUMAN AORTIC FRAGMENTS

1987 ◽  
Author(s):  
D Pintigny ◽  
L J Wautier ◽  
B Andreassian ◽  
P J Caen
Keyword(s):  
Vessel Wall ◽  
Platelet Adhesion ◽  
Gel Filtration ◽  
Dry Weight ◽  
Normal Subjects ◽  
Sodium Chromate ◽  
Pathological Conditions ◽  
Platelet Aggregates ◽  
Sclerotic Plaques ◽  
Adhesion Of Platelets

Due to the fact that the adhesion of platelet aggregates to microdamaged sites in the vascular endothelium holds a critical step in the pathogenesis of thrombotic and sclerotic plaques, we investigated the adhesion of platelets to arteritic vessel wall. Aortic samples were obtained from patients with peripheral vascular disease who required a prosthetic replacement in their aortic bifurcation. Aortic fragments were collected into buffer and tested within 24 hours after collection. The adhesion of normal platelets to the vessel fragment and the prostacyclin (PGI2) production were tested in 11 cases. Washed platelets from normal subjects were labeled with (51Cr)-sodium chromate, and incubated with aortic fragment or collagen. Non adherent platelets were separated by gel filtration through a Sepharose 2B column. Synthesis of PGI2 by the same aortic fragments was measured as 6-Keto-PGF1α a by radioimmunoassay after stimulation by thrombin (1 u/ml). In one case synthesis of PGI2 was high (80.9 ng/g dry-weight) and platelet adhesion was low (38.0%); in the other cases when PGI2 level was between 0.8 and 19.3 ng/g the adhesion was (a) low in 4 cases (0.7-40.3%) or (b) high in 6 (66.7-95.9%). In comparison adhesion to collagen performed in parallel was 78.5-95.7%. No correlation was found between platelet adhesion and the capacity to synthetize PGI2. These results suggest that in pathological conditions, when the endothelium is abnormal, platelet adhesion is not exclusively dependent on the PGI2 synthesis. In addition, this technique offers a quantitative test to measure the vessel wall thrombogenecity and its possible modulation by therapeutic agents.

Influence of coexisting myringosclerosis on myringoplasty outcomes in children

2009 ◽  
Vol 123 (9) ◽  
pp. 969-972 ◽  
Author(s):  
L Migirov ◽  
A Volkov
Keyword(s):  
Success Rate ◽  
Tympanic Membrane ◽  
Medical Records ◽  
High Rate ◽  
Surgical Success ◽  
Initial Surgery ◽  
Sclerotic Plaques ◽  
Age Range ◽  
Perforated Tympanic Membrane

AbstractObjective:To obtain information on the success rate of tympanoplasty with concomitant myringosclerosis.Methods:The medical records of 40 children with myringosclerosis (23 girls, 17 boys; age range six to 16 years, mean age 9.85 years) who had undergone primary tympanoplasty were retrospectively studied. Surgical success was defined as the perforation remaining closed 12 months post-operatively.Results:Sclerotic plaques occupied whole remnant eardrums in 17 patients, and were located in various parts of the eardrum in 23. Tympanosclerosis associated with myringosclerosis was present in six patients. The success rate of primary tympanoplasty was 92.5 per cent. All three surgical failures were observed in girls with marginal perforations. These children underwent successful revision procedures for their residual perforations, variously at four, eight and 10 months after the initial surgery.Conclusion:Appropriate freshening of the perforation edges, with removal of sclerotic plaques, can result in a high rate of successful closure of perforated tympanic membrane with coexisting myringosclerosis.

Sclerotic Plaques

2015 ◽  
pp. 173-176
Author(s):  
Diya F. Mutasim
Keyword(s):  
Sclerotic Plaques

Injection of vapor into a porous medium saturated with gas and paraffin

2008 ◽  
Vol 6 ◽  
pp. 210-216
Author(s):  
F.I. Shagieva ◽  
V.Sh. Shagapov
Keyword(s):  
Phase Transition ◽  
Porous Medium ◽  
Porous Media ◽  
Melting Point ◽  
Heat Consumption ◽  
Additional Heat ◽  
Porous Catalysts ◽  
Sclerotic Plaques

The problem of injecting steam into a porous medium saturated with gas is considered. It is believed that the skeleton of a porous medium consists of two components, one of which has a melting point lower than the temperature of the injected vapor. Therefore, this component will undergo a phase transition with additional heat consumption. This type of problem occurs in processes associated with cleaning the porous media from sclerotic plaques, mining bitumen oils, regenerating porous catalysts.

scholarly journals Acid lipase: a histochemical and biochemical study using triton X100-naphtyl palmitate micelles.

1978 ◽  
Vol 26 (9) ◽  
pp. 696-712 ◽  
Author(s):  
T Schaffner ◽  
V M Elner ◽  
M Bauer ◽  
R W Wissler
Keyword(s):  
Enzyme Activity ◽  
Neutral Lipids ◽  
Biochemical Study ◽  
Reticuloendothelial System ◽  
Acid Lipase ◽  
Human Acid ◽  
Specific Localization ◽  
Lipase A ◽  
Sclerotic Plaques ◽  
Triton X

Hydrolsis of a-naphtyl palmitate dispersed with the detergent Triton X-100 at acid pH was studied by a histochemical diazocoupling technique in both fixed sections and cultures of primate tissues as well as by a biochemical assay employing the same chromogenic substrate. Evidence for the exclusive hydrolysis of this artificial fatty acid ester substrate by acid lipases was gathered from (1) comparison of isoelectric focusing zymograms developed with different substrates, (2) kinetic analysis of enzyme activity in the presence or absence of inhibitors, including a natural substrate of acid lipase, trioleylglycerol, (3) specific localization of marked enzyme activity in certain tissues, and (4) absence of detectable enzyme activity in a case of human acid lipase deficiency (Wolman's disease). Histochemically, acid lipase activity was most readily detected in cells active in the uptake and processing of neutral lipids, i.e., the phagocytes of the reticuloendothelial system, the adrenal cortex and the lipid-storing cells in the athero-sclerotic plaques of arteries.

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