Rhabdomyomatous Mesenchymal Hamartoma: A Deep Subcutaneous Lesion in the Sternoclavicular Area

Luz Orozco-Covarrubias; Daniel Carrasco-Daza; Ana Diaz-Noriega; Leticia Lara-Mendoza; Ramon Ruiz-Maldonado

doi:10.1111/pde.12731

Rhabdomyomatous Mesenchymal Hamartoma: A Deep Subcutaneous Lesion in the Sternoclavicular Area

Pediatric Dermatology ◽

10.1111/pde.12731 ◽

2016 ◽

Vol 33 (1) ◽

pp. e36-e37 ◽

Cited By ~ 5

Author(s):

Luz Orozco-Covarrubias ◽

Daniel Carrasco-Daza ◽

Ana Diaz-Noriega ◽

Leticia Lara-Mendoza ◽

Ramon Ruiz-Maldonado

Keyword(s):

Mesenchymal Hamartoma ◽

Subcutaneous Lesion

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Recurrent Mesenchymal Hamartoma Associated with 19q Translocation. A Call for More Radical Surgical Resection

European Journal of Pediatric Surgery ◽

10.1055/s-2005-873072 ◽

2006 ◽

Vol 16 (1) ◽

pp. 64-67 ◽

Cited By ~ 21

Author(s):

K. Sharif ◽

P. Ramani ◽

H. Lochbühler ◽

R. Grundy ◽

J. de Ville de Goyet

Keyword(s):

Surgical Resection ◽

Mesenchymal Hamartoma ◽

Radical Surgical Resection

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A Rare Case of Cardiac Mesenchymal Hamartoma and Comprehensive Review of the Literature With Emphasis on Histopathology

International Journal of Surgical Pathology ◽

10.1177/10668969211002264 ◽

2021 ◽

pp. 106689692110022

Author(s):

Soma Jobbagy ◽

Simmi Patel ◽

Charles Marboe ◽

Jie-Gen Jiang ◽

Zsolt Jobbagy

Keyword(s):

Smooth Muscle ◽

Unusual Case ◽

Smooth Muscle Actin ◽

Cell Lineage ◽

Left Ventricular ◽

Mesenchymal Hamartoma ◽

Neoplastic Lesions ◽

Intramuscular Hemangioma ◽

Immunohistochemical Studies ◽

Adipose Cells

Hamartomas are primary, benign neoplastic lesions that most commonly derive from a single variably differentiated cell lineage. Here, we report an unusual case of a cardiac hamartoma. A 62-year-old woman presented with chest pain and palpitations. Serial imaging revealed a large slowly growing and highly vascularized left ventricular mass, which required surgical resection. Microscopically, the lesion was composed of nodular fibrovascular proliferation with haphazardly embedded muscle bundles and peripheral calcifications. Immunohistochemical studies revealed prominent muscle-specific actin positive and smooth muscle actin positive muscle fiber bundles within a disorganized fibrovascular stroma. This characterization is most consistent with cardiac mesenchymal hamartoma. Relevant differential diagnoses for this lesion include hamartoma of mature cardiac myocytes (HMCMs) and intramuscular hemangioma. The prominent smooth muscle differentiation of muscle bundles was incompatible with defining features of HMCM. Absence of S100-positive nerve and mature adipose cells distinguished this lesion from the recently defined, heterogeneous cardiac mesenchymal hamartoma. Forty-seven cases of cardiac hamartoma reported from 1970 to 2020 were reviewed to provide histopathologic context.

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Bilateral Mesenchymal Hamartoma of the Chest Wall in an Infant Boy

Fetal and Pediatric Pathology ◽

10.3109/15513815.2012.659412 ◽

2012 ◽

Vol 31 (6) ◽

pp. 415-422 ◽

Cited By ~ 6

Author(s):

Rong Li ◽

David Kelly ◽

Gene P. Siegal

Keyword(s):

Chest Wall ◽

Mesenchymal Hamartoma

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Cutaneous Mesenchymal Hamartoma

The Journal of Dermatology ◽

10.1111/j.1346-8138.1994.tb01769.x ◽

1994 ◽

Vol 21 (6) ◽

pp. 434-437 ◽

Cited By ~ 5

Author(s):

Sung Nam Chang ◽

Seung Hun Lee ◽

Sung Ku Ahn

Keyword(s):

Mesenchymal Hamartoma

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Atypical Hepatic Mesenchymal Hamartoma: Histologic Appearance, Immunophenotype, and Molecular Findings

Pediatric and Developmental Pathology ◽

10.1177/1093526618806750 ◽

2018 ◽

Vol 22 (4) ◽

pp. 365-369 ◽

Cited By ~ 1

Author(s):

Dina El Demellawy ◽

James YJ Lee ◽

Laura McDonell ◽

David A Dyment ◽

AS Knisely ◽

...

Keyword(s):

In Situ Hybridization ◽

Tandem Duplication ◽

Benign Neoplasm ◽

Chromosomal Microarray ◽

Chromosomal Microarray Analysis ◽

Mesenchymal Hamartoma ◽

Genetic Abnormality ◽

Circulating Lymphocytes ◽

Histopathologic Findings

Hepatic mesenchymal hamartoma is a rare benign neoplasm principally encountered in young children. Its origin is unknown. We report an unusual hepatic mesenchymal hamartoma in a 7-month-old girl, including histopathologic findings, immunophenotype, and karyotype. Chromosomal microarray analysis of tumoral tissue and circulating lymphocytes found 4 copies of a segment at 1q44 and fluorescence in situ hybridization indicated tandem triplication, ascribed to expansion of a paternal tandem duplication. This genetic abnormality may have played a role in pathogenesis.

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