scholarly journals Longitudinal evaluation of visual P300 amplitude in clinical high‐risk subjects: An event‐related potential study

2020 ◽  
Vol 74 (10) ◽  
pp. 527-534 ◽  
Author(s):  
Naoya Oribe ◽  
Yoji Hirano ◽  
Elisabetta Re ◽  
Raquelle I. Mesholam‐Gately ◽  
Kristen A. Woodberry ◽  
...  
Keyword(s):  
High Risk ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Clinical High Risk ◽  
Longitudinal Evaluation ◽  
Potential Study ◽  
Visual P300

scholarly journals Abnormally Large Baseline P300 Amplitude Is Associated With Conversion to Psychosis in Clinical High Risk Individuals With a History of Autism: A Pilot Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Jennifer H. Foss-Feig ◽  
Sylvia B. Guillory ◽  
Brian J. Roach ◽  
Eva Velthorst ◽  
Holly Hamilton ◽  
...  
Keyword(s):  
High Risk ◽  
Help Seeking ◽  
Autism Spectrum ◽  
Small Sample ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Clinical High Risk ◽  
Auditory Oddball ◽  
The North ◽  
History Of

Psychosis rates in autism spectrum disorder (ASD) are 5–35% higher than in the general population. The overlap in sensory and attentional processing abnormalities highlights the possibility of related neurobiological substrates. Previous research has shown that several electroencephalography (EEG)-derived event-related potential (ERP) components that are abnormal in schizophrenia, including P300, are also abnormal in individuals at Clinical High Risk (CHR) for psychosis and predict conversion to psychosis. Yet, it is unclear whether P300 is similarly sensitive to psychosis risk in help-seeking CHR individuals with ASD history. In this exploratory study, we leveraged data from the North American Prodrome Longitudinal Study (NAPLS2) to probe for the first time EEG markers of longitudinal psychosis profiles in ASD. Specifically, we investigated the P300 ERP component and its sensitivity to psychosis conversion across CHR groups with (ASD+) and without (ASD–) comorbid ASD. Baseline EEG data were analyzed from 304 CHR patients (14 ASD+; 290 ASD–) from the NAPLS2 cohort who were followed longitudinally over two years. We examined P300 amplitude to infrequent Target (10%; P3b) and Novel distractor (10%; P3a) stimuli from visual and auditory oddball tasks. Whereas P300 amplitude attenuation is typically characteristic of CHR and predictive of conversion to psychosis in non-ASD sample, in our sample, history of ASD moderated this relationship such that, in CHR/ASD+ individuals, enhanced – rather than attenuated - visual P300 (regardless of stimulus type) was associated with psychosis conversion. This pattern was also seen for auditory P3b amplitude to Target stimuli. Though drawn from a small sample of CHR individuals with ASD, these preliminary results point to a paradoxical effect, wherein those with both CHR and ASD history who go on to develop psychosis have a unique pattern of enhanced neural response during attention orienting to both visual and target stimuli. Such a pattern stands out from the usual finding of P300 amplitude reductions predicting psychosis in non-ASD CHR populations and warrants follow up in larger scale, targeted, longitudinal studies of those with ASD at clinical high risk for psychosis.

F209. Semantic Processing Abnormalities and Their Relationship to Symptoms in Persons at Clinical High Risk for Schizophrenia: An Event-Related Brain Potential Study

2018 ◽  
Vol 83 (9) ◽  
pp. S320
Author(s):  
Jennifer Lepock ◽  
Romina Mizrahi ◽  
Cory Gerritsen ◽  
Margaret Maheandiran ◽  
Lauren Drvaric ◽  
...  
Keyword(s):  
High Risk ◽  
Semantic Processing ◽  
Clinical High Risk ◽  
Brain Potential ◽  
Potential Study

scholarly journals Theta phase synchrony is sensitive to corollary discharge abnormalities in early illness schizophrenia but not in the clinical high-risk syndrome

2019 ◽  
Author(s):  
Judith M. Ford ◽  
Brian J. Roach ◽  
Rachel L. Loewy ◽  
Barbara K. Stuart ◽  
Judith M. Ford ◽  
...  
Keyword(s):  
High Risk ◽  
Spectral Power ◽  
Low Frequency ◽  
Event Related Potential ◽  
Corollary Discharge ◽  
Clinical High Risk ◽  
Phase Synchrony ◽  
Discharge Mechanism ◽  
Latency Range ◽  
Theta Phase

ABSTRACTBackgroundAcross the animal kingdom, responses in auditory cortex are dampened during vocalizing compared to passive listening, reflecting the action of the corollary discharge mechanism. In humans, it is seen as suppression of the EEG-based N1 event-related potential, with less N1-suppression seen in people with schizophrenia and those at clinical high risk (CHR) for psychosis. Because N1 is an admixture of theta (4-7Hz) power and phase synchrony, we asked which is responsible for N1 effects and if they outperform the sensitivity of N1 to corollary discharge and schizophrenia.MethodsTheta phase and power values were extracted from EEG data acquired from CHR youth (n=71), early illness schizophrenia patients (ESZ; n=84), and healthy controls (HC; n=103) as they said /ah/ (Talk) and then listened to the sounds played back (Listen). A principal components analysis extracted theta inter-trial coherence (ITC; phase consistency) and event related spectral power, peaking in the N1 latency range.ResultsTheta ITC-suppression (Cohen d=1.46) was greater than N1-suppression in HC (Cohen d=.63). Both were both reduced in ESZ, but only N1-suppression was reduced in CHR. When deprived of the variance shared with theta-ITC suppression, N1-suppression was no longer sensitive to HC vs. ESZ or HC vs. CHR group differences. Deficits in theta ITC-suppression were correlated with delusions (p=.007) in ESZ. Suppression of theta power was not affected by Group.ConclusionsTheta ITC-suppression may provide a simpler assay of the corollary discharge mechanism than N1-suppression. Deficits in circuits that generate low frequency oscillations may be an important component of schizophrenia.

P300 Amplitude and Topography in an Autobiographical Oddball Paradigm Involving Simulated Amnesia

2002 ◽  
Vol 16 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Antoinette R. Miller ◽  
J. Peter Rosenfeld ◽  
Matthew Soskins ◽  
Marianne Jhee
Keyword(s):  
Task Difficulty ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Oddball Paradigm ◽  
Amplitude Difference ◽  
P300 Component ◽  
Oddball Task

Abstract The P300 component of the event-related potential was recorded during two blocks of an autobiographical oddball task. All participants performed honestly during the first block (Phone), i.e., the oddball stimuli were phone numbers. During the second block (Birthday), in which the oddball stimuli were participants' birthdays, a Truth group (N = 13) performed honestly and a Malinger group (N = 14) simulated amnesia. Amnesia simulation significantly reduced P300 amplitudes, both between groups and within the Malinger group (Phone vs. Birthday), possibly because of an increase in task difficulty in the Malinger condition. Analysis of scaled amplitudes also indicated a trend for a feigning-related alteration in P300 topography. Bootstrapping of peak-to-peak amplitudes detected significantly more (93%) Malinger individuals than bootstrapping of baseline-to-peak amplitudes (64%). Bootstrapping also provided evidence of a feigning-related amplitude difference between oddball stimuli (i.e., Phone > Birthday) in 71% of Malinger group individuals. In this comparison, the peak-to-peak measure also performed significantly better in intraindividual diagnostics.

Response-Specific Scalp Distributions in Deception Detection and ERP Correlates of Psychopathic Personality Traits

2004 ◽  
Vol 18 (1) ◽  
pp. 13-26 ◽  
Author(s):  
Antoinette R. Miller ◽  
J. Peter Rosenfeld
Keyword(s):  
Deception Detection ◽  
Event Related Potential ◽  
Psychopathic Personality ◽  
P300 Amplitude ◽  
Group Differences ◽  
Post Hoc Analysis ◽  
P300 Component ◽  
Psychopathic Personality Inventory ◽  
Post Hoc ◽  
First Time

Abstract University students were screened using items from the Psychopathic Personality Inventory and divided into high (n = 13) and low (n = 11) Psychopathic Personality Trait (PPT) groups. The P300 component of the event-related potential (ERP) was recorded as each group completed a two-block autobiographical oddball task, responding honestly during the first (Phone) block, in which oddball items were participants' home phone numbers, and then feigning amnesia in response to approximately 50% of items in the second (Birthday) block in which oddball items were participants' birthdates. Bootstrapping of peak-to-peak amplitudes correctly identified 100% of low PPT and 92% of high PPT participants as having intact recognition. Both groups demonstrated malingering-related P300 amplitude reduction. For the first time, P300 amplitude and topography differences were observed between honest and deceptive responses to Birthday items. No main between-group P300 effects resulted. Post-hoc analysis revealed between-group differences in a frontally located post-P300 component. Honest responses were associated with late frontal amplitudes larger than deceptive responses at frontal sites in the low PPT group only.

Task switching in mild job burnout: An event-related potential study

2011 ◽  
Author(s):  
L. Sokka ◽  
V. Kalakoski ◽  
M. Haavisto ◽  
J. Korpela ◽  
A. Henelius ◽  
...  
Keyword(s):  
Task Switching ◽  
Job Burnout ◽  
Event Related Potential ◽  
Potential Study
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