scholarly journals Paternal age contribution to brain white matter aberrations in autism spectrum disorder

2019 ◽  
Vol 73 (10) ◽  
pp. 649-659 ◽  
Author(s):  
Walid Yassin ◽  
Masaki Kojima ◽  
Keiho Owada ◽  
Hitoshi Kuwabara ◽  
Wataru Gonoi ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Paternal Age ◽  
Brain White Matter

Diametrical relationship between gray and white matter volumes in autism spectrum disorder and schizophrenia

2016 ◽  
Vol 11 (6) ◽  
pp. 1823-1835 ◽  
Author(s):  
Serge A. Mitelman ◽  
Marie-Cecile Bralet ◽  
M. Mehmet Haznedar ◽  
Eric Hollander ◽  
Lina Shihabuddin ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Caroline Mann ◽  
◽  
Anke Bletsch ◽  
Derek Andrews ◽  
Eileen Daly ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Tissue Contrast ◽  
Effect Of Age

scholarly journals Neural correlates of polygenic risk score for autism spectrum disorders in general population

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Budhachandra Khundrakpam ◽  
Uku Vainik ◽  
Jinnan Gong ◽  
Noor Al-Sharif ◽  
Neha Bhutani ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
General Population ◽  
Cortical Thickness ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Risk Scores ◽  
Polygenic Risk ◽  
Cortical Regions ◽  
White Matter Connectivity

Abstract Autism spectrum disorder is a highly prevalent and highly heritable neurodevelopmental condition, but studies have mostly taken traditional categorical diagnosis approach (yes/no for autism spectrum disorder). In contrast, an emerging notion suggests a continuum model of autism spectrum disorder with a normal distribution of autistic tendencies in the general population, where a full diagnosis is at the severe tail of the distribution. We set out to investigate such a viewpoint by investigating the interaction of polygenic risk scores for autism spectrum disorder and Age2 on neuroimaging measures (cortical thickness and white matter connectivity) in a general population (n = 391, with age ranging from 3 to 21 years from the Pediatric Imaging, Neurocognition and Genetics study). We observed that children with higher polygenic risk for autism spectrum disorder exhibited greater cortical thickness for a large age span starting from 3 years up to ∼14 years in several cortical regions localized in bilateral precentral gyri and the left hemispheric postcentral gyrus and precuneus. In an independent case–control dataset from the Autism Brain Imaging Data Exchange (n = 560), we observed a similar pattern: children with autism spectrum disorder exhibited greater cortical thickness starting from 6 years onwards till ∼14 years in wide-spread cortical regions including (the ones identified using the general population). We also observed statistically significant regional overlap between the two maps, suggesting that some of the cortical abnormalities associated with autism spectrum disorder overlapped with brain changes associated with genetic vulnerability for autism spectrum disorder in healthy individuals. Lastly, we observed that white matter connectivity between the frontal and parietal regions showed significant association with polygenic risk for autism spectrum disorder, indicating that not only the brain structure, but the white matter connectivity might also show a predisposition for the risk of autism spectrum disorder. Our findings showed that the fronto-parietal thickness and connectivity are dimensionally related to genetic risk for autism spectrum disorder in general population and are also part of the cortical abnormalities associated with autism spectrum disorder. This highlights the necessity of considering continuum models in studying the aetiology of autism spectrum disorder using polygenic risk scores and multimodal neuroimaging.

scholarly journals Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Anna K. Prohl ◽  
◽  
Benoit Scherrer ◽  
Xavier Tomas-Fernandez ◽  
Peter E. Davis ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Neural Circuits ◽  
Diffusion Tensor ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Fiber Bundles ◽  
The Brain

Abstract Background Autism spectrum disorder (ASD) is prevalent in tuberous sclerosis complex (TSC), occurring in approximately 50% of patients, and is hypothesized to be caused by disruption of neural circuits early in life. Tubers, or benign hamartomas distributed stochastically throughout the brain, are the most conspicuous of TSC neuropathology, but have not been consistently associated with ASD. Widespread neuropathology of the white matter, including deficits in myelination, neuronal migration, and axon formation, exist and may underlie ASD in TSC. We sought to identify the neural circuits associated with ASD in TSC by identifying white matter microstructural deficits in a prospectively recruited, longitudinally studied cohort of TSC infants. Methods TSC infants were recruited within their first year of life and longitudinally imaged at time of recruitment, 12 months of age, and at 24 months of age. Autism was diagnosed at 24 months of age with the ADOS-2. There were 108 subjects (62 TSC-ASD, 55% male; 46 TSC+ASD, 52% male) with at least one MRI and a 24-month ADOS, for a total of 187 MRI scans analyzed (109 TSC-ASD; 78 TSC+ASD). Diffusion tensor imaging properties of multiple white matter fiber bundles were sampled using a region of interest approach. Linear mixed effects modeling was performed to test the hypothesis that infants who develop ASD exhibit poor white matter microstructural integrity over the first 2 years of life compared to those who do not develop ASD. Results Subjects with TSC and ASD exhibited reduced fractional anisotropy in 9 of 17 white matter regions, sampled from the arcuate fasciculus, cingulum, corpus callosum, anterior limbs of the internal capsule, and the sagittal stratum, over the first 2 years of life compared to TSC subjects without ASD. Mean diffusivity trajectories did not differ between groups. Conclusions Underconnectivity across multiple white matter fiber bundles develops over the first 2 years of life in subjects with TSC and ASD. Future studies examining brain-behavior relationships are needed to determine how variation in the brain structure is associated with ASD symptoms.

scholarly journals In Vivo Evidence of Reduced Integrity of the Gray–White Matter Boundary in Autism Spectrum Disorder

2017 ◽  
Author(s):  
Derek Sayre Andrews ◽  
Thomas A. Avino ◽  
Maria Gudbrandsen ◽  
Eileen Daly ◽  
Andre Marquand ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals White matter impairment in the speech network of individuals with autism spectrum disorder

2013 ◽  
Vol 3 ◽  
pp. 234-241 ◽  
Author(s):  
M.G. Peeva ◽  
J.A. Tourville ◽  
Y. Agam ◽  
B. Holland ◽  
D.S. Manoach ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Autism Spectrum ◽  
Spectrum Disorder
Sign in / Sign up

Export Citation Format

Share Document