Reduced duration of untreated illness over time in patients with schizophrenia spectrum, mood and anxiety disorders

2016 ◽  
Vol 70 (5) ◽  
pp. 202-210 ◽  
Author(s):  
Bernardo Dell'Osso ◽  
Lucio Oldani ◽  
Giulia Camuri ◽  
Beatrice Benatti ◽  
Benedetta Grancini ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Duration Of Untreated Illness ◽  
Mood And Anxiety Disorders ◽  
Schizophrenia Spectrum ◽  
Over Time

scholarly journals Perinatal Mood and Anxiety Disorders, Serious Mental Illness, and Delivery-Related Health Outcomes, United States, 2006-2015

2020 ◽  
Author(s):  
Kimberly Schmitt McKee ◽  
Lindsay K. Admon ◽  
Tyler N. A. Winkelman ◽  
Maria Muzik ◽  
Stephanie Hall ◽  
...  
Keyword(s):  
United States ◽  
Mental Illness ◽  
Anxiety Disorders ◽  
Serious Mental Illness ◽  
The United States ◽  
Obstetric Outcomes ◽  
Linear Regression Models ◽  
Delivery Costs ◽  
Mood And Anxiety Disorders ◽  
Over Time

Abstract Background: National estimates of perinatal mood and anxiety disorders (PMAD) and serious mental illness (SMI) among delivering women over time, as well as associated outcomes and costs, are lacking. The prevalence of perinatal mood and anxiety disorders and serious mental illness from 2006-2015 were estimated as well as associated risk of adverse obstetric outcomes, including severe maternal morbidity and mortality (SMMM), and delivery costs. Methods: The study was a serial, cross-sectional analysis of National Inpatient Sample data. The prevalence of PMAD and SMI was estimated among delivering women as well as obstetric outcomes, healthcare utilization, and delivery costs using adjusted weighted logistic with predictive margins and generalized linear regression models, respectively. Results: The study included an estimated 39,025,974 delivery hospitalizations from 2006-2015 in the U.S. PMAD increased from 18.4 (95% CI 16.4-20.0) to 40.4 (95% CI 39.3-41.6) per 1,000 deliveries. SMI also increased among delivering women over time, from 4.2 (95% CI 3.9-4.6) to 8.1 (95% CI 7.9-8.4) per 1,000 deliveries. Medicaid covered 72% (95% CI 71.2-72.9) of deliveries complicated by SMI compared to 44% (95% CI 43.1-45.0) and 43.5% (95% CI 42.5-44.5) among PMAD and all other deliveries, respectively. Women with PMAD and SMI experienced higher incidence of SMMM, and increased hospital transfers, lengths of stay, and delivery-related costs compared to other deliveries (P<.001 for all). Conclusion: Over the past decade, the prevalence of both PMAD and SMI among delivering women increased substantially across the United States, and affected women had more adverse obstetric outcomes and delivery-related costs compared to other deliveries.

scholarly journals A growing need for youth mental health services in Canada: examining trends in youth mental health from 2011 to 2018

2020 ◽  
Vol 29 ◽  
Author(s):  
K. Wiens ◽  
A. Bhattarai ◽  
P. Pedram ◽  
A. Dores ◽  
J. Williams ◽  
...  
Keyword(s):  
Mental Health ◽  
Young Adult ◽  
Mental Health Services ◽  
Health Services ◽  
Anxiety Disorders ◽  
Youth Mental Health ◽  
Adult Females ◽  
Mood And Anxiety Disorders ◽  
Mental Health Consultations ◽  
Over Time

Abstract Aims The mental health of youth is continually changing and requires reliable monitoring to ensure that adequate social and economic resources are allocated. This study assessed trends in mental health among Canadian youth, 12–24 years old. Specifically, we examined the prevalence of poor/fair perceived mental health, diagnosis of mood and anxiety disorders, suicidality, perceived stress and sleep problems, substance use, and mental health consultations. Methods Data were collected from eight cycles of the annual Canadian Community Health Survey (2011–2018). Prevalence of mental health outcomes was calculated from each survey, and meta-regression was used to assess trends over time. In the absence of a significant trend over time, the eight cycles were pooled together using meta-analysis techniques to gain precision. Trends in prevalence were assessed for the overall sample of youth (12–24 years) and separately for male and female adolescents (12–18 years) and young adults (19–24 years). Results The prevalence of poor/fair perceived mental health, diagnosed mood and anxiety disorders, and past-year mental health consultations increased from 2011 to 2018, most strongly among young adult females. Past-year suicidality increased among young adult females but did not change for other age and sex groups. Notably, the prevalence of binge drinking decreased by 2.4% per year for young adult males, 1.0% for young adult females and 0.7% per year for adolescent males, while staying relatively stable for adolescent females. Prevalence of cannabis use declined among adolescents before legalisation (2011–2017); however, this trend did not persist in 2018. Instead, the 2018 prevalence was 5.6% higher than the 2017 prevalence (16.3 v. 10.7%). The combined prevalence of other illicit drug use was stable at 4.6%; however, cocaine use and hallucinogens increased by approximately 0.2% per year. Conclusions Our findings highlight a growing need for youth mental health services, as indicated by a rise in the prevalence of diagnosed mood and anxiety disorders and past-year mental health consultations. The reason for these observed increases is less apparent – it may represent a true rise in the prevalence of mental illness, or be an artefact of change in diagnostic practices, mental health literacy or diminishing stigma. Nonetheless, the findings indicate a need for the health care system to respond to the rising demand for mental health services among youth.

scholarly journals ‘False-positive’ self-reported psychotic experiences in the general population: an investigation of outcome, predictive factors and clinical relevance

2018 ◽  
Vol 28 (5) ◽  
pp. 532-543 ◽  
Author(s):  
Y. van der Steen ◽  
I. Myin-Germeys ◽  
M. van Nierop ◽  
M. ten Have ◽  
R. de Graaf ◽  
...  
Keyword(s):  
General Population ◽  
Anxiety Disorders ◽  
False Positive ◽  
Help Seeking ◽  
Clinical Interview ◽  
Psychotic Symptoms ◽  
Psychotic Experiences ◽  
Mood And Anxiety Disorders ◽  
Over Time

Aims.Self-reported psychotic experiences (SRPE) by individuals from the general population are often unconfirmed by clinical interview and referred to as ‘false-positive’ (FP) SRPE. FP SRPE have been suggested to represent the mildest form of risk along the extended psychosis continuum. However, little is known about their (clinical) outcome and evolution over time. Aims of this study were to prospectively examine, in individuals with FP SRPE, (1) the prevalence of remission, persistence and transition to validated PE at 3-year follow-up; (2) potential baseline psychopathological and psychosocial predictors of persistence of FP SRPE and transition to validated PE; and (3) whether those with persistent FP SRPE and validated PE already differed on psychopathology and psychosocial factors at baseline. We tested the hypotheses that (i) individuals with FP SRPE would be more likely to have SRPE and validated PE at follow-up; and (ii) that FP SRPE would be predictive of lower functioning and more psychopathology and help-seeking behaviour at follow-up.Methods.Baseline (n = 6646) and 3-year follow-up (n = 5303) data of the second the Netherlands Mental Health Survey and Incidence Study (NEMESIS-2), a general population research project on prevalence, incidence, course and consequences of psychiatric disorders was used. Self-report of PE was followed by clinical interview to determine clinical validity. The presence of mood, anxiety and substance use disorders, childhood adversity, help-seeking and functioning as well as PE characteristics (number, frequency, distress and impact) were used in the analyses which included only individuals with complete data for both assessments waves (n = 4683).Results.At baseline, 454 participants had any FP SRPE; of these 372 participants had complete follow-up data available. Those with baseline FP SRPE were significantly more likely to report SRPE (OR = 3.58; 95% CI 2.38–5.40, p < 0.001) and validated PE (OR = 6.26; 95% CI 3.91–10.02, p < 0.001) at follow-up. Baseline FP SRPE also predicted the presence of mood and anxiety disorders, reduced functioning and help-seeking at follow-up. Several baseline psychopathological, psychosocial and PE characteristics were predictive for the persistence of SRPE. These factors also differentiated groups with FP SRPE or validated PE from those with remitted FP SRPE at follow-up.Conclusions.‘FP SRPE’ are not truly ‘false’ as they index risk for the development of clinically relevant psychotic symptoms, development of mood and anxiety disorders and reduced functioning. Self-reported PE, even unconfirmed, warrant ‘watchful waiting’ and follow-up over time, especially when they are reported by individuals with reduced psychosocial functioning and general psychiatric problems.

scholarly journals Perinatal Mood and Anxiety Disorders, Serious Mental Illness, and Delivery-Related Health Outcomes, United States, 2006-2015

2020 ◽  
Author(s):  
Kimberly Schmitt McKee ◽  
Lindsay K. Admon ◽  
Tyler N. A. Winkelman ◽  
Maria Muzik ◽  
Stephanie Hall ◽  
...  
Keyword(s):  
United States ◽  
Mental Illness ◽  
Anxiety Disorders ◽  
Serious Mental Illness ◽  
The United States ◽  
Obstetric Outcomes ◽  
Linear Regression Models ◽  
Delivery Costs ◽  
Mood And Anxiety Disorders ◽  
Over Time

Abstract Background: National estimates of perinatal mood and anxiety disorders (PMAD) and serious mental illness (SMI) among delivering women over time, as well as associated outcomes and costs, are lacking. We examined the prevalence of perinatal mood and anxiety disorders and serious mental illness, from 2006-2015 and associated risk of adverse obstetric outcomes, including severe maternal morbidity and mortality (SMMM), and delivery costs. We conducted a serial, cross-sectional analysis using National Inpatient Sample data. We estimated the prevalence of PMAD and SMI among delivering women as well as obstetric outcomes, healthcare utilization, and delivery costs using adjusted weighted logistic with predictive margins and generalized linear regression models, respectively. Results : We identified an estimated 39,025,974 delivery hospitalizations from 2006-2015 in the U.S. PMAD increased from 18.4 (95% CI 16.4-20.0) to 40.4 (95% CI 39.3-41.6) per 1,000 deliveries. SMI also increased among delivering women over time, from 4.2 (95% CI 3.9-4.6) to 8.1 (95% CI 7.9-8.4) per 1,000 deliveries. Medicaid covered 72% (95% CI 71.2-72.9) of deliveries complicated by SMI compared to 44% (95% CI 43.1-45.0) and 43.5% (95% CI 42.5-44.5) among PMAD and all other deliveries, respectively. Women with PMAD and SMI experienced higher incidence of SMMM, and increased hospital transfers, lengths of stay, and delivery-related costs compared to other deliveries ( P <.001 for all). Conclusion : Over the past decade, the prevalence of both PMAD and SMI among delivering women increased substantially across the United States, and affected women had more adverse obstetric outcomes and delivery-related costs compared to other deliveries.

Duration of Untreated Psychosis and Duration of Untreated Illness: New Vistas

CNS Spectrums ◽  
2010 ◽  
Vol 15 (4) ◽  
pp. 238-246 ◽  
Author(s):  
Bernardo Dell'Osso ◽  
A. Carlo Altamura
Keyword(s):  
Prognostic Factor ◽  
Anxiety Disorders ◽  
Psychotic Disorders ◽  
Duration Of Untreated Psychosis ◽  
Medline Search ◽  
Duration Of Untreated Illness ◽  
Mood And Anxiety Disorders ◽  
Negative Prognostic Factor ◽  
Clinical Consequences ◽  
Outcome Differences

ABSTRACTThe duration of untreated illness (DUI), defined as the interval between the onset of a psychiatric disorder and the administration of the first pharmacological treatment, has been increasingly investigated in the last decade as a predictor of outcome across different psychiatric conditions including schizophrenia and psychotic disorders (duration of untreated psychosis), and mood and anxiety disorders. Converging evidence indicates that a prolonged DUI may be viewed as a negative prognostic factor in schizophrenia and increasing data point toward a similar conclusion in mood and anxiety disorders. Through a Medline search, the present article highlights the role of the DUI in this group of psychiatric disorders, focusing on social and psychopathological determinants of the DUI, as well as the clinical consequences related to a longer DUI in terms of outcome. Hypotheses on neurobiological mechanisms underpinning outcome differences in relation to a prolonged DUI are provided and methodological limitations related to the assessment of the DUI in published studies and clinical practice discussed. Finally, given that DUI is supposed to be a potentially modifiable prognostic factor, intervention programs aimed to reduce this variable are briefly considered and discussed.

scholarly journals Perinatal Mood and Anxiety Disorders, Serious Mental Illness, and Delivery-Related Health Outcomes, United States, 2006-2015

2020 ◽  
Author(s):  
Kimberly Schmitt McKee ◽  
Lindsay K. Admon ◽  
Tyler N. A. Winkelman ◽  
Maria Muzik ◽  
Stephanie Hall ◽  
...  
Keyword(s):  
United States ◽  
Mental Illness ◽  
Anxiety Disorders ◽  
Serious Mental Illness ◽  
The United States ◽  
Obstetric Outcomes ◽  
Linear Regression Models ◽  
Delivery Costs ◽  
Mood And Anxiety Disorders ◽  
Over Time

Abstract Background: National estimates of perinatal mood and anxiety disorders (PMAD) and serious mental illness (SMI) among delivering women over time, as well as associated outcomes and costs, are lacking. The prevalence of perinatal mood and anxiety disorders and serious mental illness from 2006-2015 were estimated as well as associated risk of adverse obstetric outcomes, including severe maternal morbidity and mortality (SMMM), and delivery costs using a serial, cross-sectional analysis of National Inpatient Sample data. The prevalence of PMAD and SMI were estimated among delivering women as well as obstetric outcomes, healthcare utilization, and delivery costs using adjusted weighted logistic with predictive margins and generalized linear regression models, respectively. Results: The study included an estimated 39,025,974 delivery hospitalizations from 2006-2015 in the U.S. PMAD increased from 18.4 (95% CI 16.4-20.0) to 40.4 (95% CI 39.3-41.6) per 1,000 deliveries. SMI also increased among delivering women over time, from 4.2 (95% CI 3.9-4.6) to 8.1 (95% CI 7.9-8.4) per 1,000 deliveries. Medicaid covered 72% (95% CI 71.2-72.9) of deliveries complicated by SMI compared to 44% (95% CI 43.1-45.0) and 43.5% (95% CI 42.5-44.5) among PMAD and all other deliveries, respectively. Women with PMAD and SMI experienced higher incidence of SMMM, and increased hospital transfers, lengths of stay, and delivery-related costs compared to other deliveries (P<.001 for all). Conclusion: Over the past decade, the prevalence of both PMAD and SMI among delivering women increased substantially across the United States, and affected women had more adverse obstetric outcomes and delivery-related costs compared to other deliveries.

scholarly journals Perinatal Mood and Anxiety Disorders, Serious Mental Illness, and Delivery-Related Health Outcomes, United States, 2006-2015

2019 ◽  
Author(s):  
Kimberly Schmitt McKee ◽  
Lindsay K. Admon ◽  
Tyler N. A. Winkelman ◽  
Maria Muzik ◽  
Stephanie Hall ◽  
...  
Keyword(s):  
United States ◽  
Mental Illness ◽  
Anxiety Disorders ◽  
Serious Mental Illness ◽  
The United States ◽  
Obstetric Outcomes ◽  
Linear Regression Models ◽  
Delivery Costs ◽  
Mood And Anxiety Disorders ◽  
Over Time

Abstract Purpose: National estimates of perinatal mood and anxiety disorders (PMAD) and serious mental illness (SMI) among delivering women over time, as well as associated outcomes and costs, are lacking. We examined the prevalence of perinatal mood and anxiety disorders and serious mental illness, from 2006-2015 and associated risk of adverse obstetric outcomes, including severe maternal morbidity and mortality (SMMM), and delivery costs. Methods: We conducted a serial, cross-sectional analysis using National Inpatient Sample data. We estimated the prevalence of PMAD and SMI among delivering women as well as obstetric outcomes, healthcare utilization, and delivery costs using adjusted weighted logistic with predictive margins and generalized linear regression models, respectively. Results : We identified an estimated 39,025,974 delivery hospitalizations from 2006-2015 in the U.S. PMAD increased from 18.4 (95% CI 16.4-20.0) to 40.4 (95% CI 39.3-41.6) per 1,000 deliveries. SMI also increased among delivering women over time, from 4.2 (95% CI 3.9-4.6) to 8.1 (95% CI 7.9-8.4) per 1,000 deliveries. Medicaid covered 72% (95% CI 71.2-72.9) of deliveries complicated by SMI compared to 44% (95% CI 43.1-45.0) and 43.5% (95% CI 42.5-44.5) among PMAD and all other deliveries, respectively. Women with PMAD and SMI experienced higher incidence of SMMM, and increased hospital transfers, lengths of stay, and delivery-related costs compared to other deliveries ( P <.001 for all). Conclusion : Over the past decade, the prevalence of both PMAD and SMI among delivering women increased substantially across the United States, and affected women had more adverse obstetric outcomes and delivery-related costs compared to other deliveries.

Sign in / Sign up

Export Citation Format

Share Document