scholarly journals Phenotypic plasticity of melanocytes derived from human adult skin

2021 ◽  
Author(s):  
Dániel László Vidács ◽  
Zoltán Veréb ◽  
Renáta Bozó ◽  
Lili Borbála Flink ◽  
Hilda Polyánka ◽  
...  
Keyword(s):  
Phenotypic Plasticity ◽  
Human Adult ◽  
Adult Skin

scholarly journals 270 Phenotypic plasticity of melanocytes derived from human adult skin

2021 ◽  
Vol 141 (10) ◽  
pp. S195
Author(s):  
D.L. Vidacs ◽  
Z. Veréb ◽  
R. Bozó ◽  
L.B. Flink ◽  
H. Polyánka ◽  
...  
Keyword(s):  
Phenotypic Plasticity ◽  
Human Adult ◽  
Adult Skin

Generation of Fluorescently Labeled Cell Lines, C3A Hepatoma Cells, and Human Adult Skin Fibroblasts to Study Coculture Models

2013 ◽  
Vol 37 (7) ◽  
pp. E123-E130 ◽  
Author(s):  
Anna Samluk ◽  
Karolina Ewa Zakrzewska ◽  
Krzysztof Dariusz Pluta
Keyword(s):  
Cell Lines ◽  
Hepatoma Cells ◽  
Skin Fibroblasts ◽  
Human Adult ◽  
Adult Skin

VERGLEICHENDE UNTERSUCHUNGEN ÜBER DEN STOFFWECHSEL VON [4-14C] PROGESTERON IN DER FETALEN HAUT UND IN DER HAUT DES ERWACHSENEN

1972 ◽  
Vol 70 (1) ◽  
pp. 175-184 ◽  
Author(s):  
Harald Mickan
Keyword(s):  
Experimental Conditions ◽  
Human Adult ◽  
Adult Skin ◽  
Vergleichende Untersuchungen

ABSTRACT The metabolism of [4-14C] progesterone in human adult and foetal skin was investigated in vitro under identical experimental conditions. 5α-Pregnanedione and 20α-dihydroprogesterone were isolated and identified in all the experiments. In addition 3β-hydroxy-5α-pregnan-20-one, 6β-hydroxyprogesterone and tentatively 6β-hydroxy-20α-dihydroprogesterone could be identified in the experiments with foetal skin. 5α-Reductase was shown to be most active in both foetal and adult skin. 5β-saturated products were not detectable. These experiments demonstrate a significant capability of foetal skin in the metabolism of progesterone.

Studies of the intracellular Ca2+ levels in human adult skin mast cells activated by the ligand for the human c-kit receptor and anti-IgE

1994 ◽  
Vol 47 (12) ◽  
pp. 2137-2145 ◽  
Author(s):  
Michele Columbo ◽  
Luis M. Botana ◽  
Edward M. Horowitz ◽  
Lawrence M. Lichtenstein ◽  
Donald W. Macglashan
Keyword(s):  
Mast Cells ◽  
Human Adult ◽  
Kit Receptor ◽  
Adult Skin

scholarly journals Reprogramming Human Adult Fibroblasts into GABAergic Interneurons

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3450
Author(s):  
Andreas Bruzelius ◽  
Srisaiyini Kidnapillai ◽  
Janelle Drouin-Ouellet ◽  
Tom Stoker ◽  
Roger A. Barker ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Autism Spectrum ◽  
Specific Gene ◽  
Gabaergic Interneurons ◽  
Human Adult ◽  
Gene And Protein Expression ◽  
Parkinson’S Diseases ◽  
Fetal Fibroblasts ◽  
Adult Skin ◽  
Adult Fibroblasts

Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. The generated neurons can be used for both cell replacement strategies and disease modelling. Using this technique, previous studies have shown that γ-aminobutyric acid (GABA) expressing interneurons can be generated from different cell sources, such as glia cells or fetal fibroblasts. Nevertheless, the generation of neurons from adult human fibroblasts, an easily accessible cell source to obtain patient-derived neurons, has proved to be challenging due to the intrinsic blockade of neuronal commitment. In this paper, we used an optimized protocol for adult skin fibroblast reprogramming based on RE1 Silencing Transcription Factor (REST) inhibition together with a combination of GABAergic fate determinants to convert human adult skin fibroblasts into GABAergic neurons. Our results show a successful conversion in 25 days with upregulation of neuronal gene and protein expression levels. Moreover, we identified specific gene combinations that converted fibroblasts into neurons of a GABAergic interneuronal fate. Despite the well-known difficulty in converting adult fibroblasts into functional neurons in vitro, we could detect functional maturation in the induced neurons. GABAergic interneurons have relevance for cognitive impairments and brain disorders, such as Alzheimer’s and Parkinson’s diseases, epilepsy, schizophrenia and autism spectrum disorders.

scholarly journals Photocarcinogenesis in human adult skin grafts

2002 ◽  
Vol 23 (1) ◽  
pp. 181-187 ◽  
Author(s):  
C. Berking
Keyword(s):  
Skin Grafts ◽  
Human Adult ◽  
Adult Skin
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