scholarly journals Mouse models of uveal melanoma: Strengths, weaknesses, and future directions

2020 ◽  
Vol 33 (2) ◽  
pp. 264-278 ◽  
Author(s):  
Jackson R. Richards ◽  
Jae Hyuk Yoo ◽  
Donghan Shin ◽  
Shannon J. Odelberg
Keyword(s):  
Mouse Models ◽  
Uveal Melanoma ◽  
Future Directions

scholarly journals Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Takahito Sugase ◽  
Bao Q. Lam ◽  
Meggie Danielson ◽  
Mizue Terai ◽  
Andrew E. Aplin ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Mouse Models ◽  
Uveal Melanoma

scholarly journals The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
Guido N. Vacano ◽  
Nathan Duval ◽  
David Patterson
Keyword(s):  
Down Syndrome ◽  
Human Chromosome ◽  
Mouse Models ◽  
Targeted Mutagenesis ◽  
Chromosome 21 ◽  
Practical Reasons ◽  
Future Directions ◽  
Human Chromosome 21 ◽  
Biology Of Aging ◽  
Chromosome Regions

Down syndrome is a complex condition caused by trisomy of human chromosome 21. The biology of aging may be different in individuals with Down syndrome; this is not well understood in any organism. Because of its complexity, many aspects of Down syndrome must be studied either in humans or in animal models. Studies in humans are essential but are limited for ethical and practical reasons. Fortunately, genetically altered mice can serve as extremely useful models of Down syndrome, and progress in their production and analysis has been remarkable. Here, we describe various mouse models that have been used to study Down syndrome. We focus on segmental trisomies of mouse chromosome regions syntenic to human chromosome 21, mice in which individual genes have been introduced, or mice in which genes have been silenced by targeted mutagenesis. We selected a limited number of genes for which considerable evidence links them to aspects of Down syndrome, and about which much is known regarding their function. We focused on genes important for brain and cognitive function, and for the altered cancer spectrum seen in individuals with Down syndrome. We conclude with observations on the usefulness of mouse models and speculation on future directions.

scholarly journals Surgically-induced mouse models in the study of bone regeneration: Current models and future directions

2017 ◽  
Vol 15 (3) ◽  
pp. 1017-1023 ◽  
Author(s):  
Bin Ning ◽  
Yunpeng Zhao ◽  
John A. Buza ◽  
Wei Li ◽  
Wenzhao Wang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Mouse Models ◽  
Future Directions ◽  
Surgically Induced

scholarly journals Progress in human liver organoids

2020 ◽  
Vol 12 (8) ◽  
pp. 607-617
Author(s):  
Lulu Sun ◽  
Lijian Hui
Keyword(s):  
Mouse Models ◽  
Human Liver ◽  
Major Goal ◽  
Future Directions ◽  
In Vitro System ◽  
Human Liver Cells ◽  
Human Livers ◽  
Liver Organoids ◽  
Complex Organ

Abstract Understanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall short in recapitulating the features of human liver cells or the structures and functions of human livers. Organoids as an in vitro system hold the promise to generate organ-like tissues in a dish. Recent advances in human liver organoids also facilitate the understanding of the biology and diseases in this complex organ. Here we review the progress in human liver organoids, mainly focusing on the methods to generate liver organoids, their applications, and possible future directions.

scholarly journals Mouse models of human disease. Part II: recent progress and future directions.

1997 ◽  
Vol 11 (1) ◽  
pp. 11-43 ◽  
Author(s):  
M A Bedell ◽  
D A Largaespada ◽  
N A Jenkins ◽  
N G Copeland
Keyword(s):  
Mouse Models ◽  
Human Disease ◽  
Recent Progress ◽  
Future Directions
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