scholarly journals Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells

2017 ◽  
Vol 31 (1) ◽  
pp. 51-63 ◽  
Author(s):  
Yash Chhabra ◽  
Hilary X.L. Yong ◽  
Mitchell E. Fane ◽  
Arish Soogrim ◽  
Wen Lim ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Interferon Gamma ◽  
Growth Characteristics ◽  
Interferon Gamma Response ◽  
Tyrosinase Expression

scholarly journals Treatment of human acute schistosomiasis with oxamniquine induces an increase in interferon-gamma response to Schistosoma mansoni antigens

2007 ◽  
Vol 102 (2) ◽  
pp. 225-228 ◽  
Author(s):  
Joelma R de Souza ◽  
Clarice NL Morais ◽  
Marcílio L Aroucha ◽  
Paulo JC Miranda ◽  
Constança S Barbosa ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Interferon Gamma ◽  
Interferon Gamma Response

scholarly journals Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Michael C Kiritsy ◽  
Katelyn McCann ◽  
Daniel Mott ◽  
Stephen M Holland ◽  
Samuel M Behar ◽  
...  
Keyword(s):  
T Cells ◽  
Interferon Gamma ◽  
Mitochondrial Respiration ◽  
Complex I ◽  
Immunological Synapse ◽  
Antigen Presenting Cells ◽  
Mitochondrial Respiratory Chain ◽  
Relative Effect ◽  
Antigen Presenting ◽  
Interferon Gamma Response

The immunological synapse allows antigen presenting cells (APC) to convey a wide array of functionally distinct signals to T cells, which ultimately shape the immune response. The relative effect of stimulatory and inhibitory signals is influenced by the activation state of the APC, which is determined by an interplay between signal transduction and metabolic pathways. While pathways downstream of toll-like receptors rely on glycolytic metabolism for the proper expression of inflammatory mediators, little is known about the metabolic dependencies of other critical signals such as interferon gamma (IFNg). Using CRISPR-Cas9, we performed a series of genome-wide knockout screens in murine macrophages to identify the regulators of IFNg-inducible T cell stimulatory or inhibitory proteins MHCII, CD40, and PD-L1. Our multi-screen approach enabled us to identify novel pathways that control these functionally distinct markers. Further integration of these screening data implicated complex I of the mitochondrial respiratory chain in the expression of all three markers, and by extension the IFNg signaling pathway. We report that the IFNg response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I. These findings suggest a dichotomous metabolic dependency between IFNg and toll-like receptor signaling, implicating mitochondrial function as a fulcrum of innate immunity.

scholarly journals Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients

2006 ◽  
Vol 101 (8) ◽  
pp. 857-861 ◽  
Author(s):  
Ricardo Candido Oliveira Tavares ◽  
Jorge Salgado ◽  
Valéria Barbosa Moreira ◽  
Mônica Antonia S Ferreira ◽  
Fernanda Carvalho Queoz Mello ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mycobacterium Tuberculosis ◽  
Interferon Gamma ◽  
Tuberculosis Patients ◽  
Interferon Gamma Response

scholarly journals Upregulation of SOCS-3 and PIAS-3 Impairs IL-12-Mediated Interferon-Gamma Response in CD56+ T Cells in HCV-Infected Heroin Users

PLoS ONE ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. e9602 ◽  
Author(s):  
Li Ye ◽  
Xu Wang ◽  
David S. Metzger ◽  
Eric Riedel ◽  
Luis J. Montaner ◽  
...  
Keyword(s):  
T Cells ◽  
Interferon Gamma ◽  
Heroin Users ◽  
Interferon Gamma Response

scholarly journals The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

2012 ◽  
Vol 8 (6) ◽  
pp. e1002784 ◽  
Author(s):  
Wendy Niedelman ◽  
Daniel A. Gold ◽  
Emily E. Rosowski ◽  
Joris K. Sprokholt ◽  
Daniel Lim ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Interferon Gamma ◽  
Human Interferon ◽  
Interferon Gamma Response
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