scholarly journals Synergistic targeted inhibition of MEK and dual PI 3K/ mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma

2016 ◽  
Vol 29 (6) ◽  
pp. 643-655 ◽  
Author(s):  
Bih‐Rong Wei ◽  
Helen T. Michael ◽  
Charles H.C. Halsey ◽  
Cody J. Peer ◽  
Amit Adhikari ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Mucosal Melanoma ◽  
Preclinical Model ◽  
Targeted Inhibition ◽  
Canine Melanoma

scholarly journals Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis

2019 ◽  
Vol 97 (7) ◽  
pp. 957-972 ◽  
Author(s):  
Yan Ma ◽  
Michael Baltezor ◽  
Lian Rajewski ◽  
Jennifer Crow ◽  
Glenson Samuel ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Histone Deacetylase ◽  
Ewing Sarcoma ◽  
Signaling Axis ◽  
Targeted Inhibition

scholarly journals Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases

Oncotarget ◽  
2015 ◽  
Vol 6 (16) ◽  
pp. 14413-14427 ◽  
Author(s):  
Audrey Lamora ◽  
Mathilde Mullard ◽  
Jérôme Amiaud ◽  
Régis Brion ◽  
Dominique Heymann ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Anticancer Activity ◽  
Lung Metastases ◽  
Preclinical Model ◽  
Inhibition Of Tumor Growth

Targeted inhibition of osteosarcoma tumor growth by bone marrow-derived mesenchymal stem cells expressing cytosine deaminase/5-fluorocytosine in tumor-bearing mice

2015 ◽  
Vol 17 (3-5) ◽  
pp. 87-99 ◽  
Author(s):  
Quynh-Anh NguyenThai ◽  
Neelesh Sharma ◽  
Do Huynh Luong ◽  
Simrinder Singh Sodhi ◽  
Jeong-Hyun Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Tumor Growth ◽  
Cytosine Deaminase ◽  
Tumor Bearing ◽  
Targeted Inhibition

scholarly journals Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model

2021 ◽  
Vol 11 ◽  
Author(s):  
Tianyun Qiao ◽  
Yanlu Xiong ◽  
Yangbo Feng ◽  
Wenwen Guo ◽  
Yongsheng Zhou ◽  
...  
Keyword(s):  
T Cells ◽  
Mouse Model ◽  
Tumor Growth ◽  
Cd8 T Cells ◽  
Immune Cells ◽  
Preclinical Model ◽  
Small Subset ◽  
Therapeutic Effects ◽  
Humanized Mouse ◽  
Humanized Mouse Model

Immunotherapy is a curable treatment for certain cancers, but it is still only effective in a small subset of patients, partly because of the lack of sufficient immune cells in the tumor. It is reported that targeted lactate dehydrogenase (LDH) to reduce lactic acid production can promote the infiltration and activity of immune cells and turn tumors into hot tumors. Therefore, we constructed a humanized mouse model to evaluate the efficacy of using classical LDH inhibitor oxamate and pembrolizumab alone or in combination in non-small cell lung cancer (NSCLC). We found that both oxamate and pembrolizumab monotherapy significantly delayed tumor growth; moreover, combination therapy showed better results. Immunofluorescence analysis showed that oxamate treatment increased the infiltration of activated CD8+ T cells in the tumor, which might have enhanced the therapeutic effects of pembrolizumab. Treatment of the humanized mice with anti-CD8 abrogated the therapeutic effects of oxamate, indicating CD8+ T cells as the main force mediating the effect of oxamate. In conclusion, Our preclinical findings position that oxamate not only inhibits tumor growth at a high safe dose but also enhances the efficacy of pembrolizumab in Hu-PBMC-CDX mice. Our study also provides a preclinical model for exploring the efficacy of other immune-based combination therapies for NSCLC.

Abstract 3245: Targeted inhibition of Hedgehog (HH) signal transduction in rhabdomyosarcoma (RMS) reduces cell survival in vitro and tumor growth in vivo

2015 ◽  
Author(s):  
Joon Won Yoon ◽  
Christopher Chandler ◽  
Marilyn Lamm ◽  
King-Fu Leong ◽  
Stephen Iannaccone ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Tumor Growth ◽  
Cell Survival ◽  
Targeted Inhibition

Psychological stress enhances tumor growth and diminishes radiation response in preclinical model of lung cancer

2020 ◽  
Vol 146 ◽  
pp. 126-135 ◽  
Author(s):  
Yi Zhang ◽  
Panos Zanos ◽  
Isabel L. Jackson ◽  
Xiuwu Zhang ◽  
Xiongzhao Zhu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Growth ◽  
Psychological Stress ◽  
Radiation Response ◽  
Preclinical Model
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