The role of the metastasis suppressor gene KAI1 in melanoma angiogenesis

2015 ◽  
Vol 28 (6) ◽  
pp. 696-706 ◽  
Author(s):  
Yun Tang ◽  
Madhuri Bhandaru ◽  
Yabin Cheng ◽  
Jing Lu ◽  
Gang Li ◽  
...  
Keyword(s):  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene

scholarly journals Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression

Oncogene ◽  
2004 ◽  
Vol 23 (33) ◽  
pp. 5675-5681 ◽  
Author(s):  
Sucharita Bandyopadhyay ◽  
Sudha K Pai ◽  
Shigeru Hirota ◽  
Sadahiro Hosobe ◽  
Yukio Takano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Tumor Metastasis ◽  
Suppressor Gene ◽  
Breast Cancer Progression ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene

Role of tumor metastasis suppressor gene KAI1 in digestive tract carcinomas and cancer cells

2003 ◽  
Vol 314 (2) ◽  
pp. 237-249 ◽  
Author(s):  
Qiao Wu ◽  
Yuan Ji ◽  
Ming-qing Zhang ◽  
Yu-qiang Chen ◽  
Fu Chen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Digestive Tract ◽  
Tumor Metastasis ◽  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene

scholarly journals Role of Metastasis Suppressor KAI1/CD82 in Different Cancers

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Wei Yan ◽  
Jinny Huang ◽  
Qian Zhang ◽  
Jian Zhang
Keyword(s):  
Poor Prognosis ◽  
Tumor Metastasis ◽  
Malignant Tumors ◽  
Suppressor Gene ◽  
Tumor Formation ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene ◽  
Metastasis Suppressor Genes ◽  
Potential Strategy

Metastasis is one of the characteristics of malignant tumors and the main cause of death worldwide. The process of metastasis is mainly affected by tumor metastasis genes, tumor metastasis suppressor genes, tumor microenvironment, extracellular matrix degradation, and other factors. Thus, it is essential to elucidate the mechanism of metastasis and find the therapeutic targets in order to prevent the development of malignant tumors. KAI1/CD82, a member of tetraspanin superfamily of glycoproteins, has been reported as a tumor metastasis suppressor gene in various types of cancers without affecting the tumor formation. Many studies have demonstrated that low expression of KAI1/CD82 might lead to poor prognosis due to its interactions with other tetraspanins and integrins, resulting in the regulation of cell motility and invasion, cell-cell adhesion, and apoptosis. Considering its pathological and physiological significance, KAI1/CD82 could be a potential strategy for clinical predicting and preventing tumor progression and metastasis. The present review aims to discuss the role of KAI1/CD82 in metastasis for different cancers and examine its prospects as a metastasis biomarker and a therapeutic target.

EP300-A miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas

2009 ◽  
Vol 126 (1) ◽  
pp. 114-124 ◽  
Author(s):  
Soeren Torge Mees ◽  
Wolf Arif Mardin ◽  
Claudia Wendel ◽  
Nicole Baeumer ◽  
Edith Willscher ◽  
...  
Keyword(s):  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene

scholarly journals Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers

2019 ◽  
Vol 39 (5) ◽  
Author(s):  
Qian Zhang ◽  
Jin-yan Wang ◽  
Wei Yan ◽  
Dan-dan Wang ◽  
Su-jin Yang ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Therapeutic Strategy ◽  
Malignant Tumors ◽  
Homo Sapiens ◽  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene ◽  
Ceramide Synthase ◽  
Invasion And Metastasis ◽  
Human Cancers

Abstract Homo sapiens ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumor metastasis suppressor gene in diverse cancers. Thus, low level of CerS-2 protein might suggest a bad prognosis and up-regulation of CerS-2 protein might act as a promising therapeutic strategy for malignant tumors. In this review, we discussed the expression, as well as the clinical and pathological significance of CerS-2 in diverse human cancers. The pathological processes and molecular pathways regulated by CerS-2 were also summarized.

Mutation and expression of the metastasis suppressor gene KAI1 in esophageal squamous cell carcinoma

Cancer ◽  
2000 ◽  
Vol 89 (5) ◽  
pp. 955-962 ◽  
Author(s):  
Tatsuya Miyazaki ◽  
Hiroyuki Kato ◽  
Yoshinori Shitara ◽  
Minako Yoshikawa ◽  
Kouhei Tajima ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene
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