scholarly journals Acute exposure to ultraviolet-B radiation modulates sex steroid hormones and receptor expression in the skin and may contribute to the sex bias of melanoma in a fish model

2014 ◽  
Vol 27 (3) ◽  
pp. 408-417 ◽  
Author(s):  
David L. Mitchell ◽  
André A. Fernandez ◽  
Rachel Garcia ◽  
Lakshmi Paniker ◽  
Kevin Lin ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Ultraviolet B ◽  
Receptor Expression ◽  
Acute Exposure ◽  
Sex Steroid ◽  
Sex Bias ◽  
Fish Model ◽  
Ultraviolet B Radiation

scholarly journals Investigating the Interactive Effects of Sex Steroid Hormones and Brain-Derived Neurotrophic Factor during Adolescence on Hippocampal NMDA Receptor Expression

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Cushla R. McCarthny ◽  
Xin Du ◽  
YeeWen Candace Wu ◽  
Rachel A. Hill
Keyword(s):  
Steroid Hormones ◽  
Neurotrophic Factor ◽  
Hormone Treatment ◽  
Brain Derived Neurotrophic Factor ◽  
Sex Steroid Hormones ◽  
Receptor Expression ◽  
Interactive Effects ◽  
Sex Steroid ◽  
Androgen Treatment ◽  
Female Sex Hormones

Sex steroid hormones have neuroprotective properties which may be mediated by brain-derived neurotrophic factor (BDNF). This study sought to determine the interactive effects of preadolescent hormone manipulation and BDNF heterozygosity (+/−) on hippocampal NMDA-R expression. Wild-type and BDNF+/−mice were gonadectomised, and females received either 17β-estradiol or progesterone treatment, while males received either testosterone or dihydrotestosterone (DHT) treatment. Dorsal (DHP) and ventral hippocampus (VHP) were dissected, and protein expression of GluN1, GluN2A, GluN2B, and PSD-95 was assessed by Western blot analysis. Significant genotype × OVX interactions were found for GluN1 and GluN2 expression within the DHP of female mice, suggesting modulation of select NMDA-R levels by female sex hormones is mediated by BDNF. Furthermore, within the DHP BDNF+/−mice show a hypersensitive response to hormone treatment on GluN2 expression which may result from upstream alterations in TrkB phosphorylation. In contrast to the DHP, the VHP showed no effects of hormone manipulation but significant effects of genotype on NMDA-R expression. Castration had no effect on NMDA-R expression; however, androgen treatment had selective effects on GluN2B. These data show case distinct, interactive roles for sex steroid hormones and BDNF in the regulation of NMDA-R expression that are dependent on dorsal versus ventral hippocampal region.

scholarly journals Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Zeng ◽  
Zhuoyu Yang ◽  
Jiang Li ◽  
Yan Wen ◽  
Zheng Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Hormone Exposure ◽  
Female Lung Cancer

Abstract Background Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure specifically on the risk of lung cancer in women. Methods The PubMed, MEDLINE, Web of Science, and EMBASE databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for female lung cancer risk associated with sex steroid hormones were calculated overall and by study design, publication year, population, and smoking status. Sensitivity analysis, publication bias, and subgroup analysis were performed. Results Forty-eight studies published between 1987 and 2019 were included in the study with a total of 31,592 female lung cancer cases and 1,416,320 subjects without lung cancer. Overall, higher levels of sex steroid hormones, both endogenous (OR: 0.92, 95% CI: 0.87–0.98) and exogenous (OR: 0.86, 95% CI: 0.80–0.93), significantly decreased the risk of female lung cancer by 10% (OR: 0.90, 95% CI: 0.86–0.95). The risk of lung cancer decreased more significantly with a higher level of sex steroid hormones in non-smoking women (OR: 0.88, 95% CI: 0.78–0.99) than in smoking women (OR: 0.98, 95% CI: 0.77–1.03), especially in Asia women (OR: 0.84, 95% CI: 0.74–0.96). Conclusions Our meta-analysis reveals an association between higher levels of sex steroid hormone exposure and the decreased risk of female lung cancer. Surveillance of sex steroid hormones might be used for identifying populations at high risk for lung cancer, especially among non-smoking women.

Circulating Levels of Sex Steroid Hormones and Gastric Cancer

2021 ◽  
Author(s):  
Yelda A. Leal ◽  
Minkyo Song ◽  
Jovanny Zabaleta ◽  
Gilberto Medina-Escobedo ◽  
Patrick Caron ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Circulating Levels

Associations between circulating sex steroid hormones and cognition in normal elderly women

Neurology ◽  
2000 ◽  
Vol 54 (3) ◽  
pp. 599-599 ◽  
Author(s):  
E. B. Drake ◽  
V. W. Henderson ◽  
F. Z. Stanczyk ◽  
C. A. McCleary ◽  
W. S. Brown ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Elderly Women ◽  
Sex Steroid Hormones ◽  
Sex Steroid
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