scholarly journals Safety Risk Associated With Use of Nonsteroidal Anti‐inflammatory Drugs in Japanese Elderly Compared to Younger Patients With Osteoarthritis and/or Chronic Low Back Pain: A Retrospective Database Study

Pain Practice ◽  
2021 ◽  
Author(s):  
Kanae Togo ◽  
Nozomi Ebata ◽  
Naohiro Yonemoto ◽  
Lucy Abraham
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Younger Patients ◽  
Safety Risk ◽  
Database Study ◽  
Japanese Elderly ◽  
Inflammatory Drugs ◽  
Retrospective Database

scholarly journals Patterns of drug treatment in patients with osteoarthritis and chronic low back pain in Japan: a retrospective database study

2019 ◽  
Vol Volume 12 ◽  
pp. 1631-1648 ◽  
Author(s):  
Manabu Akazawa ◽  
Wataru Mimura ◽  
Kanae Togo ◽  
Nozomi Ebata ◽  
Noriko Harada ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Drug Treatment ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Database Study ◽  
Retrospective Database

scholarly journals Efficacy and Safety of Duloxetine in Patients with Chronic Low Back Pain Who Used versus Did Not Use Concomitant Nonsteroidal Anti-Inflammatory Drugs or Acetaminophen: A Post Hoc Pooled Analysis of 2 Randomized, Placebo-Controlled Trials

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Vladimir Skljarevski ◽  
Peng Liu ◽  
Shuyu Zhang ◽  
Jonna Ahl ◽  
James M. Martinez
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Pooled Analysis ◽  
Analysis Of Covariance ◽  
Low Back ◽  
Substantial Evidence ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Post Hoc

This subgroup analysis assessed the efficacy of duloxetine in patients with chronic low back pain (CLBP) who did or did not use concomitant nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen (APAP). Data were pooled from two 13-week randomized trials in patients with CLBP who were stratified according to NSAID/APAP use at baseline: duloxetine NSAID/APAP user (), placebo NSAID/APAP user (), duloxetine NSAID/APAP nonuser (), and placebo NSAID/APAP nonuser (). NSAID/APAP users were those patients who took NSAID/APAP for at least 14 days per month during 3 months prior to study entry. An analysis of covariance model that included therapy, study, baseline NSAID/APAP use (yes/no), and therapy-by-NSAID/APAP subgroup interaction was used to assess the efficacy. The treatment-by-NSAID/APAP use interaction was not statistically significant () suggesting no substantial evidence of differential efficacy for duloxetine over placebo on pain reduction or improvement in physical function between concomitant NSAID/APAP users and non-users.

scholarly journals Non-steroidal anti-inflammatory drugs for chronic low back pain

2016 ◽  
Author(s):  
Wendy TM Enthoven ◽  
Pepijn DDM Roelofs ◽  
Richard A Deyo ◽  
Maurits W van Tulder ◽  
Bart W Koes
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Deep Tissue Massage and Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain: A Prospective Randomized Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Marian Majchrzycki ◽  
Piotr Kocur ◽  
Tomasz Kotwicki
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Pain Reduction ◽  
Control Group ◽  
Low Back ◽  
Deep Tissue ◽  
Significant Difference ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Objective. To investigate whether chronic low back pain therapy with deep tissue massage (DTM) gives similar results to combined therapy consisting of DTM and non-steroid anti-inflammatory drugs (NSAID).Design. Prospective controlled randomized single blinded trial.Settings. Ambulatory care of rehabilitation.Participants. 59 patients, age 51.8 ± 9.0 years, with chronic low back pain.Interventions. 2 weeks of DTM in the treatment group (TG) versus 2 weeks of DTM combined with NSAID in the control group (CG).Main Outcome Measures. Visual analogue scale, Oswestry disability index (ODI), and Roland-Morris questionnaire (RM).Results. In both the TG and the CG, a significant pain reduction and function improvement were observed. VAS decreased from 58.3 ± 18.2 to 42.2 ± 21.1 (TG) and from 51.8 ± 18.8 to 30.6 ± 21.9 (CG). RM value decreased from 9.8 ± 5.1 to 6.4 ± 4.4 (TG), and from 9.3 ± 5.5 to 6.1 ± 4.6 (CG). ODI value decreased from 29.2 ± 17.3 to 21.4 ± 15.1 (TG) and from 21.4 ± 9.4 to 16.6 ± 9.4 (CG). All pre-post-treatment differences were significant; however, there was no significant difference between the TG and the CG.Conclusion. DTM had a positive effect on reducing pain in patients with chronic low back pain. Concurrent use of DTM and NSAID contributed to low back pain reduction in a similar degree that the DTM did.

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