scholarly journals Predictors of Long‐Term Opioid Effectiveness in Patients With Chronic Non‐Cancer Pain Attending Multidisciplinary Pain Treatment Clinics: A Quebec Pain Registry Study

Pain Practice ◽  
2020 ◽  
Vol 20 (6) ◽  
pp. 588-599
Author(s):  
Jean‐Luc Kaboré ◽  
Hichem Saïdi ◽  
Lise Dassieu ◽  
Manon Choinière ◽  
M. Gabrielle Pagé
Keyword(s):  
Cancer Pain ◽  
Pain Treatment ◽  
Registry Study ◽  
Multidisciplinary Pain Treatment

scholarly journals Inducible Lentivirus-Mediated siRNA against TLR4 Reduces Nociception in a Rat Model of Bone Cancer Pain

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ruirui Pan ◽  
Huiting Di ◽  
Jinming Zhang ◽  
Zhangxiang Huang ◽  
Yuming Sun ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Pain Treatment ◽  
Intrathecal Injection ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Prolonged Treatment ◽  
Small Interference Rna ◽  
Long Term Treatment ◽  
Walker 256

Although bone cancer pain is still not fully understood by scientists and clinicians alike, studies suggest that toll like receptor 4 (TLR4) plays an important role in the initiation and/or maintenance of pathological pain state in bone cancer pain. A promising treatment for bone cancer pain is the downregulation of TLR4 by RNA interference; however, naked siRNA (small interference RNA) is not effective in long-term treatments. In order to concoct a viable prolonged treatment for bone cancer pain, an inducible lentivirus LvOn-siTLR4 (tetracycline inducible lentivirus carrying siRNA targeting TLR4) was prepared and the antinociception effects were observed in bone cancer pain rats induced by Walker 256 cells injection in left leg. Results showed that LvOn-siTLR4 intrathecal injection with doxycycline (Dox) oral administration effectively reduced the nociception induced by Walker 256 cells while inhibiting the mRNA and protein expression of TLR4. Proinflammatory cytokines as TNF-αand IL-1βin spinal cord were also decreased. These findings suggest that TLR4 could be a target for bone cancer pain treatment and tetracycline inducible lentivirus LvOn-siTLR4 represents a new potential option for long-term treatment of bone cancer pain.

Interventional procedures in children and adolescents with chronic non-cancer pain as part of a multidisciplinary pain treatment program

2018 ◽  
Vol 28 (11) ◽  
pp. 999-1006 ◽  
Author(s):  
Eduardo Vega ◽  
Gonzalo Rivera ◽  
Ghislaine C. Echevarria ◽  
Zakhar Prylutskyy ◽  
Jordi Perez ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Children And Adolescents ◽  
Treatment Program ◽  
Interventional Procedures ◽  
Pain Treatment ◽  
Multidisciplinary Pain Treatment

scholarly journals Role of neuraxial drug delivery in cancer pain therapy

2020 ◽  
Vol 2 (4) ◽  
pp. FDD49
Author(s):  
Edgar Ross ◽  
Roshni Ramachandran ◽  
Jason D Ross ◽  
Ashish Bhandari ◽  
Patrick W Mantyh ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Pain Treatment ◽  
Current Evidence ◽  
Oncologic Surgery ◽  
Cancer Pain Therapy ◽  
Continued Use ◽  
Long Term Prognosis ◽  
New Treatment

Opioids have long been the mainstay of cancer pain treatment and have been used without any consideration for their effect on cancer growth and long-term prognosis. There is now growing evidence that the continued use of opioids for this indication should be reviewed and even reconsidered. Although current evidence and literature covering this subject is mixed and does not yet allow for a clear determination to be made about safety, there is enough data to support the search for new treatment paradigms, beginning with anesthesia for oncologic surgery and management of cancer pain over the disease course.

Physical medicine Prediction of long term outcome of multidisciplinary pain treatment

Pain ◽  
1987 ◽  
Vol 30 (1) ◽  
pp. 133
Author(s):  
T. P. Guck ◽  
P. W. Melman ◽  
F. Skultety ◽  
M. Dowd
Keyword(s):  
Pain Treatment ◽  
Physical Medicine ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Multidisciplinary Pain Treatment
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