Comment on a Paper by Leysen et al. Entitled “Chronic Pain in Breast Cancer Survivors: Nociceptive, Neuropathic, or Central Sensitization Pain?”

Pain Practice ◽  
2019 ◽  
Vol 19 (7) ◽  
pp. 785-786 ◽  
Author(s):  
Munetaka Hirose ◽  
Yumiko Takao
Keyword(s):  
Breast Cancer ◽  
Chronic Pain ◽  
Cancer Survivors ◽  
Central Sensitization ◽  
Breast Cancer Survivors

scholarly journals Chronic Pain in Breast Cancer Survivors: Nociceptive, Neuropathic, or Central Sensitization Pain?

Pain Practice ◽  
2018 ◽  
Vol 19 (2) ◽  
pp. 183-195 ◽  
Author(s):  
Laurence Leysen ◽  
Nele Adriaenssens ◽  
Jo Nijs ◽  
Roselien Pas ◽  
Thomas Bilterys ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chronic Pain ◽  
Cancer Survivors ◽  
Central Sensitization ◽  
Breast Cancer Survivors

957 CHRONIC PAIN AND OTHER SEQUELAE IN BREAST CANCER SURVIVORS: A NATIONWIDE STUDY IN DENMARK

2006 ◽  
Vol 10 (S1) ◽  
pp. S248-S248
Author(s):  
V. Peuckmann ◽  
O. Ekholm ◽  
N.K. Rasmussen ◽  
S. Moller ◽  
P. Christiansen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chronic Pain ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Nationwide Study

A Web-and-Mobile-Based Intervention for Women Treated for Breast Cancer to Manage Chronic Pain and Symptoms Related to Lymphedema: Results of a Randomized Clinical Trial (Preprint)

2021 ◽  
Author(s):  
Mei Rosemary Fu ◽  
Deborah Axelrod ◽  
Amber A Guth ◽  
Joan Scagliola ◽  
Kavita Rampertaap ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chronic Pain ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Flow System ◽  
Bodily Pain ◽  
Intervention Group ◽  
Lymph Flow ◽  
Limb Volume ◽  
The Web

BACKGROUND The-Optimal-Lymph-Flow is a patient-centered, web-and-mobile-based mHealth system that delivers safe, easy and feasible digital therapy of lymphatic exercises and limb mobility exercises. The purpose of this randomized clinical trial (RCT) was to evaluate the effectiveness of the web-and-mobile-based The-Optimal-Lymph-Flow system for managing chronic pain and symptoms related to lymphedema. OBJECTIVE The primary objective of this study was to determine the effectiveness of the web-and-mobile-based The-Optimal-Lymph-Flow system for managing chronic pain, aching, soreness, and tenderness among breast cancer survivors and quality of life related to pain. The secondary objective was to evaluate the effectiveness of the web-and-mobile-based The-Optimal-Lymph-Flow system for managing symptoms related to lymph fluid accumulation, limb volume differences, and body mass index (BMI). METHODS A parallel randomized controlled trial (RCT) with a control-experimental, pre- and post-test, repeated-measures design. A total of 120 patients were recruited and randomized according to pain with 1:1 ratio into either Arm Precaution (AP) control focusing on limb mobility and protection or The-Optimal-Lymph flow (TOLF) intervention focusing promoting lymph flow and limb mobility. Trial outcomes were evaluated at baseline and week 12 post intervention. Descriptive statistics, Fisher’s Exact tests, Wilcoxon rank-sum tests, t-test, and generalized linear mixed-effects models were performed for data analysis. RESULTS At the study endpoint of week 12 post intervention, significantly fewer patients in the TOLF intervention group compared to AP control group reported chronic pain (49% vs. 71%; OR=0.39, CI=[0.17, 0.90], p=0.021). Patients in TOLF intervention group were significantly more likely to experience a complete reduction in chronic pain (50% vs 22%; OR=3.56, CI = [1.39, 9.76], p=0.005), and soreness (43% vs 22%; OR=2.60, CI = [1.03, 6.81], p=0.034). Significantly lower median severity scores were found in TOLF group for chronic pain (〖Med〗_LE=0, IQR=0-1 vs 〖Med〗_AP=1, IQR=0-2; p=0.024) and general bodily pain (〖Med〗_LE=1, IQR=0-1.5 vs 〖Med〗_AP=1, IQR=1-3; p=0.040). Compared to AP control, significantly fewer patients in TOLF group reported arm/hand swelling (p=0.038); heaviness (p=0.027), redness (p=0.033), limited movement in shoulder (p=0.015) and arm (p=0,025). No significant differences between TOLF and AP groups were found in complete reduction of aching and tenderness, mean numbers of lymphedema symptom reported, > 5% limb volume differences, and BMI. CONCLUSIONS TOLF intervention had significant benefits for breast cancer survivors to manage chronic pain, soreness, general bodily pain, limb swelling, heaviness, and impaired limb mobility. TOLF intervention resulted in a 13% reduction in proportions of patients who took pain medications compared to AP group which had a 5% increase. A 12% reduction in proportions of patients with > 5% limb volume differences were found in the TOLF group while a 5% increase in the AP group. Taking together, TOLF intervention can be a better choice for breast cancer survivors to reduce chronic pain and limb volume. CLINICALTRIAL US Clinicaltrials.gov NCT02462226, https://clinicaltrials.gov/ct2/show/NCT02462226

Patient-reported pain and other symptoms among breast cancer survivors: prevalence and risk factors

2020 ◽  
Vol 106 (6) ◽  
pp. 480-490
Author(s):  
Michele Divella ◽  
Luigi Vetrugno ◽  
Serena Bertozzi ◽  
Luca Seriau ◽  
Carla Cedolini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Chronic Pain ◽  
Neuropathic Pain ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Breast Tissue ◽  
Shoulder Function ◽  
Breast Cancer Surgery ◽  
Patient Reported

Objective: To investigate the prevalence and risk factors associated with chronic pain and other symptoms related to breast cancer 6 months after surgery. Methods: In an observational study of 261 female breast cancer survivors treated between January 2017 and January 2018, patients were asked about their pain symptoms using a questionnaire that utilized the Numeric Rating Score (NRS) and the Douleur Neuropathique Score (DN4) for neuropathic pain; it also addressed phantom sensations and functional disorders on the ipsilateral shoulder. A total of 218 women completed the survey. Results: A total of 105 patients (48.17%) reported chronic pain. Of these, 64% rated the pain with an NRS of 1–3 and 35% with an NRS >3. Neuropathic pain was reported in 65% of the sample, phantom sensations in 12%, disorders of shoulder function in 16%, and web syndrome in 2%. Multivariable analyses showed that chronic pain (odds ratio [OR], 2.55; 95% confidence interval [CI], 1.094–5.942; p < 0.05) and neuropathic pain (OR, 2.988; 95% CI, 1.366–6.537; p < 0.05) were positively associated with surgical adverse events; phantom sensations were statistically associated with the weight of removed breast tissue (OR, 1.003; 95% CI, 1.001–1.005; p < 0.05). Conclusions: Our study highlights the need to employ specific tools capable of detecting different kinds of chronic pain after breast cancer surgery to improve pain prevention and treatment. Surgical complications and the weight of removed breast tissue emerged as 2 of the risk factors for chronic and neuropathic pain development in breast cancer survivors.

Characterization of chronic pain in breast cancer survivors using the McGill Pain Questionnaire

2015 ◽  
Vol 19 (4) ◽  
pp. 651-655 ◽  
Author(s):  
Vânia Tie Koga Ferreira ◽  
Elaine Caldeira de Oliveira Guirro ◽  
Almir Vieira Dibai-Filho ◽  
Simone Mara de Araújo Ferreira ◽  
Ana Maria de Almeida
Keyword(s):  
Breast Cancer ◽  
Chronic Pain ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Mcgill Pain Questionnaire ◽  
Pain Questionnaire
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