scholarly journals Results of Lumbar Endoscopic Adhesiolysis Using a Radiofrequency Catheter in Patients with Postoperative Fibrosis and Persistent or Recurrent Symptoms After Discectomy

Pain Practice ◽  
2014 ◽  
Vol 16 (1) ◽  
pp. 67-79 ◽  
Author(s):  
Paulo Pereira ◽  
Milton Severo ◽  
Pedro Monteiro ◽  
Pedro Alberto Silva ◽  
Virgínia Rebelo ◽  
...  
Keyword(s):  
Postoperative Fibrosis

scholarly journals Effect of postoperative corticosteroids on surgical outcome and aqueous autotaxin following combined cataract and microhook ab interno trabeculotomy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Megumi Honjo ◽  
Reiko Yamagishi ◽  
Nozomi Igarashi ◽  
Chui Yong Ku ◽  
Makoto Kurano ◽  
...  
Keyword(s):  
Surgical Outcome ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Case Series ◽  
Iop Elevation ◽  
Immunoenzymatic Assay ◽  
Postoperative Fibrosis ◽  
Ab Interno

AbstractTo evaluate the effect of postoperative corticosteroids on surgical outcome and autotaxin (ATX) levels after microhook ab interno trabeculotomy combined with cataract surgery (μLOT-CS), prospective, consecutive non-randomized case series comparing outcomes of 30 eyes with primary open angle glaucoma was performed. The aqueous ATX, intraocular pressure (IOP) and glaucoma medications were monitored for 3 months postoperatively. An in-vivo mouse μLOT model was generated. In vitro, ATX and fibrotic changes induced by dexamethasone (Dex) treatment following scratch (S) in cultured human trabecular meshwork (hTM) cells were assessed by immunofluorescence, immunoenzymatic assay, and RT-qPCR. Postoperative ATX at 1 week and the number of antiglaucoma medications at 3 months were significantly lower in non-steroid group, and steroid use was the only variable significantly associated with postoperative medications at 3 months in multiregression analyses. In vitro, ATX activity was significantly upregulated in the Dex + S group, and αSMA was significantly upregulated in the Dex and Dex + S groups. Fibronectin and COL1A1 were significantly upregulated in the S group. μLOT-CS decreased IOP and medications in the overall cohort, and non-use of postoperative steroids resulted in a smaller number of postoperative medications. Limiting postoperative steroids in μLOT may minimize IOP elevation and postoperative fibrosis.

scholarly journals Postoperative fibrosis suppression

2002 ◽  
Vol 86 (12) ◽  
pp. 1323-1322
Author(s):  
A L Schwartz
Keyword(s):  
Postoperative Fibrosis

scholarly journals Effects of rosiglitazone/PHBV drug delivery system on postoperative fibrosis in rabbit glaucoma filtration surgery model

Drug Delivery ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 812-819 ◽  
Author(s):  
Feng Zhang ◽  
Ke Liu ◽  
Zheng Pan ◽  
Mengdan Cao ◽  
Dengming Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Postoperative Fibrosis

scholarly journals Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

2012 ◽  
Vol 303 (7) ◽  
pp. G786-G801 ◽  
Author(s):  
Florian Rieder ◽  
Sean Kessler ◽  
Miquel Sans ◽  
Claudio Fiocchi
Keyword(s):  
Animal Models ◽  
Intestinal Tract ◽  
Stricture Formation ◽  
Therapeutic Approaches ◽  
Intestinal Fibrosis ◽  
Key Characteristics ◽  
Inflammatory Processes ◽  
Radiation Induced ◽  
Underlying Mechanisms ◽  
Postoperative Fibrosis

Fibrosis is a serious condition complicating chronic inflammatory processes affecting the intestinal tract. Advances in this field that rely on human studies have been slow and seriously restricted by practical and logistic reasons. As a consequence, well-characterized animal models of intestinal fibrosis have emerged as logical and essential systems to better define and understand the pathophysiology of fibrosis. In point of fact, animal models allow the execution of mechanistic studies as well as the implementation of clinical trials with novel, pathophysiology-based therapeutic approaches. This review provides an overview of the currently available animal models of intestinal fibrosis, taking into consideration the methods of induction, key characteristics of each model, and underlying mechanisms. Currently available models will be classified into seven categories: spontaneous, gene-targeted, chemical-, immune-, bacteria-, and radiation-induced as well as postoperative fibrosis. Each model will be discussed in regard to its potential to create research opportunities to gain insights into the mechanisms of intestinal fibrosis and stricture formation and assist in the development of effective and specific antifibrotic therapies.

MRI differentiation of recurrent colorectal carcinoma from postoperative fibrosis

1986 ◽  
Vol 11 (1) ◽  
pp. 361-363 ◽  
Author(s):  
Jacqueline S. Gomberg ◽  
Arnold C. Friedman ◽  
Paul D. Radecki ◽  
Kathyrn Grumbach ◽  
Dina F. Caroline
Keyword(s):  
Colorectal Carcinoma ◽  
Recurrent Colorectal Carcinoma ◽  
Postoperative Fibrosis

Different fibroblast subpopulations of the eye: A therapeutic target to prevent postoperative fibrosis in glaucoma therapy

2012 ◽  
Vol 100 ◽  
pp. 88-97 ◽  
Author(s):  
Thomas Stahnke ◽  
Marian Löbler ◽  
Christian Kastner ◽  
Oliver Stachs ◽  
Andreas Wree ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Glaucoma Therapy ◽  
Postoperative Fibrosis

Cellular Photoablation to Control Postoperative Fibrosis in Filtration Surgery: in vitro Studies

2000 ◽  
Vol 70 (2) ◽  
pp. 145-152 ◽  
Author(s):  
SALVATORE GRISANTI ◽  
ARTUR GRALLA ◽  
PATRIK MAURER ◽  
MICHAEL DIESTELHORST ◽  
GÜNTER KRIEGLSTEIN ◽  
...  
Keyword(s):  
In Vitro Studies ◽  
Filtration Surgery ◽  
Postoperative Fibrosis
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