0.025% Capsaicin Gel for the Treatment of Painful Diabetic Neuropathy: A Randomized, Double-Blind, Crossover, Placebo-Controlled Trial

Pain Practice ◽  
2012 ◽  
Vol 13 (6) ◽  
pp. 497-503 ◽  
Author(s):  
Kongkiat Kulkantrakorn ◽  
Chakraphong Lorsuwansiri ◽  
Pongsatorn Meesawatsom
Keyword(s):  
Diabetic Neuropathy ◽  
Controlled Trial ◽  
Painful Diabetic Neuropathy ◽  
Double Blind

scholarly journals Intravenous methylcobalamin effectively ameliorated painful diabetic neuropathy: A randomized double-blind placebo controlled trial

2021 ◽  
Vol 20 (3) ◽  
pp. 335-341
Author(s):  
Thomas Eko Purwata ◽  
◽  
I Putu Eka Widyadharma ◽  
Made Rudy ◽  
Andreas Soejitno ◽  
...  
Keyword(s):  
Treatment Group ◽  
Diabetic Neuropathy ◽  
Rating Scale ◽  
Controlled Trial ◽  
Control Group ◽  
Painful Diabetic Neuropathy ◽  
Double Blind ◽  
Entire Study ◽  
Double Blind Placebo ◽  
And Control

Objective. Painful diabetic neuropathy (PDN) is a prevalent debilitating consequence of diabetes mellitus with lack of satisfactory therapeutic options. Methylcobalamin (MeCbl) is one of vitamin B12 analogs with known neurotrophic effects. We aimed to determine if MeCbl can relieve PDN. Materials and methods. This was a randomized (1:1) double-blind placebo-controlled trial involving PDN patients. Treatment and control group received daily 12.5 mg oral amitriptyline bid with either 500 µg of intravenous MeCbl or saline injection given on alternating days, respectively, for a 9-consecutive day period. PDN was assessed with douleur neuropathique 4 (DN4) questionnaire. Numeric pain rating scale (NPRS) was used to monitor pain intensity and treatment response. All investigators and patients were kept blinded throughout the study period. Outcomes. 42 patients, 21 on each arm had completed the study. The NPRS reduction can already be observed as early as day 2 post-intervention. Both the treatment and control group demonstrated sustained reduction of NPRS by almost one point per each time point of evaluation in the first three days (p<0.001). NPRS reduction remained until the end of the study period. The treatment group had a significantly lower NPRS score by 1.29 than that of the control group during the entire study period (95% CI -1.84 – -0.75; p < 0.001). Treatment group experienced significantly higher NPRS reduction when compared with control (4.19±1.54 vs. 2.1± 0.83; 95% CI 1.32-2.87; p < 0.001), i.e. 62.6% from baseline. Conclusions. MeCbl significantly and safely relieved PDN in a relatively rapid onset.

0.075% capsaicin lotion for the treatment of painful diabetic neuropathy: A randomized, double-blind, crossover, placebo-controlled trial

2019 ◽  
Vol 62 ◽  
pp. 174-179 ◽  
Author(s):  
Kongkiat Kulkantrakorn ◽  
Assawin Chomjit ◽  
Pasiri Sithinamsuwan ◽  
Thipaporn Tharavanij ◽  
Juthamas Suwankanoknark ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Controlled Trial ◽  
Painful Diabetic Neuropathy ◽  
Double Blind

Lacosamide in Painful Diabetic Neuropathy: An 18-Week Double-Blind Placebo-Controlled Trial

2009 ◽  
Vol 10 (8) ◽  
pp. 818-828 ◽  
Author(s):  
Aziz Shaibani ◽  
Salah Fares ◽  
Jean-Louis Selam ◽  
Armen Arslanian ◽  
Jeffrey Simpson ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Controlled Trial ◽  
Painful Diabetic Neuropathy ◽  
Double Blind ◽  
Double Blind Placebo

16-LB: Long-Term 10 kHz Spinal Cord Stimulation in Painful Diabetic Neuropathy: A Randomized Controlled Trial

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 16-LB
Author(s):  
ERIKA PETERSEN ◽  
JAMES SCOWCROFT ◽  
ELIZABETH S. BROOKS ◽  
JUDITH L. WHITE ◽  
KASRA AMIRDELFAN ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Randomized Controlled Trial ◽  
Diabetic Neuropathy ◽  
Spinal Cord Stimulation ◽  
Controlled Trial ◽  
Painful Diabetic Neuropathy ◽  
Randomized Controlled
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