Anesthesiologist‐Related Factors Associated with Risk‐Adjusted Pediatric Anesthesia‐Related Cardiopulmonary Arrest: A Retrospective Two Level Analysis

2021 ◽  
Author(s):  
Robert Christensen ◽  
Bishr Haydar ◽  
Aleda Leis ◽  
Graciela Mentz ◽  
Paul Reynolds
Keyword(s):  
Cardiopulmonary Arrest ◽  
Pediatric Anesthesia ◽  
Related Factors ◽  
Factors Associated ◽  
Level Analysis

İstanbul İlçelerinin Nüfus Değişimi ve Kütük Bilgilerinin Analizi

2019 ◽  
Vol 6 (1) ◽  
pp. 37-72
Author(s):  
Ulaş Sunata ◽  
Dila Ergül
Keyword(s):  
Population Growth ◽  
Population Growth Rate ◽  
Population Change ◽  
Urban Migration ◽  
Specific Population ◽  
Related Factors ◽  
Internal Migrant ◽  
Level Analysis ◽  
Study District ◽  
Demographic Features

39 ilçesiyle Türkiye’nin en büyük nüfusuna sahip ili İstanbul aynı zamanda Türkiye’nin en çok iç göç alan şehridir. Özellikle kırdan kente göç bağlamında sosyo-ekonomik ve demografik özellikleriyle birçok araştırmaya konu olmuştur. Fakat İstanbul yerleşik nüfusunun Türkiye’nin diğer şehirlerine kayıtlı olma yoğunluğu da önemlidir. Bu çalışmanın amacı 2012 ve 2017 yıllarındaki nüfus değişimini göz önünde bulundurarak İstanbul ilçelerinin ayrıntılı nüfus yoğunluğu ve büyüme analizini yapmak, ilgili faktörleri değerlendirmek, hemşehri ağlarını okumak adına yerleşik nüfus kütük bilgileri bakımından inceleyerek elde edilen örüntüler doğrultusunda ilçe tipolojileri oluşturmaktır. Çalışmanın birinci bölümünde ilgili beş yıllık nüfus değişimlerine göre İstanbul ilçe nüfusları analiz edilmiştir. Ardından her bir ilçe için nüfusa kayıtlı olunan kente göre nüfus büyüme hızlarına bakılarak ilçelerin ağırlıklı olarak barındırdığı hemşehri ağları belirlenmiştir. İkinci bölümde ise ilçeler nüfus değişim özelliklerine göre belirli kategorilere ayrılmış ve bu kategoriler doğrultusunda ilçe tipolojileri oluşturulmuştur..ABSTRACT IN ENGLISHA District Level Analysis of Istanbul’s Population Change (2012-2017)Istanbul having the largest population of Turkey with its 39 districts is the most internal-migrant-receiving city in Turkey. Particularly in the context of rural-to-urban migration, Istanbul has been became a subject of various researches with its socio-economic and demographic features. However, the density of Istanbul’s settled population who registered other cities of Turkey is important. The main aim of this study is to analyse population growth of all districts considering the population change between 2012 and 2017, to evaluate the related factors and to develop a district typology by using the data of settled population according to their family registration in the name of reading the current countryman networks. In the first section of the study, district populations of Istanbul are examined regarding the related five-year change. Afterwards, most repeated countryman networks of all Istanbul’s districts are specified regarding the population growth rate of the registered cities. In the latter section of the study, districts were divided into categories regarding the specific population change features which help to create district typology.

Management of Recurrent or Progressing Skull Base Chondrosarcomas: Predictors of Long-Term Outcomes

2020 ◽  
Author(s):  
Jonathan D. Breshears ◽  
Franco DeMonte ◽  
Ahmed Habib ◽  
Paul W. Gidley ◽  
Shaan M. Raza
Keyword(s):  
Natural History ◽  
Skull Base ◽  
Radiation Treatment ◽  
Systemic Disease ◽  
Primary Treatment ◽  
Salvage Treatment ◽  
Low Grade ◽  
Related Factors ◽  
Factors Associated ◽  
Initial Recurrence

Abstract Background Skull base chondrosarcomas (CSA) are difficult tumors to cure and there is little data regarding salvage therapy. Objective This study aims to identify presentation and treatment-related factors which impact the progression free survival (PFS) and disease specific survival (DSS) for recurrent CSA, and to identify salvage treatment factors associated with successful restoration to the natural history following primary treatment. Methods This single-institution retrospective review included patients with recurrent/progressive CSA over a 25-year period. Survival analysis for factors impacting PFS and DSS was performed. Salvage treatment factors associated with achieving PFS ≥newly diagnosed median PFS were identified using univariate statistics. Analysis was performed on first recurrences and all recurrences combined. Results A total of 47 recurrence/progression events were analyzed from 17 patients (median two events/patient, range = 1–8). The overall PFS and DSS for the initial recurrence was 32 (range = 3–267) and 79 (range = 3–285) months, respectively. Conventional grade III or mesenchymal histology significantly predicted shorter PFS and DSS (p < 0.0001). After stratification by histology, previous radiation predicted shorter PFS for low-grade tumors (p = 0.009). Gross total resection (GTR) after a first time recurrence was significantly associated with successful salvage treatment (p < 0.05); however, this was rare. Conclusion In this series, high grade histology and prior radiation treatment negatively impacted salvage treatment outcomes, while GTR was associated with restoration to natural history following primary treatment. Careful consideration of histology, systemic disease status, previous treatments, and the anatomic extent of the skull base disease can optimize the outcomes of salvage intervention.

Comprehensive genomics depict accessory genes encoding pathogenicity and biofilm determinants in Enterococcus faecalis

2021 ◽  
Vol 16 (3) ◽  
pp. 175-184
Author(s):  
Karthika Suryaletha ◽  
Sivakumar K Chandrika ◽  
Sabu Thomas
Keyword(s):  
Enterococcus Faecalis ◽  
Signaling System ◽  
Phosphotransferase System ◽  
Related Factors ◽  
Polysaccharide Lyase ◽  
Factors Associated ◽  
Analysis Methodology ◽  
Accessory Genes ◽  
Genes Encoding ◽  
Phage Proteins

Aim: Enterococcus faecalis is a leading nosocomial pathogen in biofilm-associated polymicrobial infections. The study aims to understand pathogenicity and biofilm determinants of the pathogen by genome analysis. Methodology: Genome sequencing of a strong biofilm forming clinical isolate Enterococcus faecalis SK460 devoid of Fsr quorum-signaling system, was performed and comparative genomics was carried out among a set of pathogenic biofilm formers and nonpathogenic weak biofilm formers. Results: Analysis revealed a pool of virulence and adhesion related factors associated with pathogenicity. Absence of CRISPR-Cas system facilitated acquisition of pheromone responsive plasmid, pathogenicity island and phages. Comprehensive analysis identified a subset of accessory genes encoding polysaccharide lyase, sugar phosphotransferase system, phage proteins and transcriptional regulators exclusively in pathogenic biofilm formers. Conclusion: The study identified a set of genes specific to pathogenic biofilm formers and these can act as targets which in turn help to develop future treatment endeavors against enterococcal infections.

Prevalence and family factors associated with loneliness during COVID-19: A cross-sectional study from South India

2020 ◽  
Vol 3 (02) ◽  
pp. 61-67
Author(s):  
G. Sanjana ◽  
Vijaya Raghavan
Keyword(s):  
Online Survey ◽  
South India ◽  
Survey Design ◽  
Southern India ◽  
Related Factors ◽  
Cross Sectional ◽  
Health Crisis ◽  
Factors Associated ◽  
Family Discord ◽  
The Impact

Background: Loneliness can affect anyone at any point in their life. It can be detrimental to the wellbeing and quality of life of individuals and communities. In the ongoing COVID-19 pandemic, loneliness is considered as a public health crisis. Hence, the objectives of the study were to estimate the prevalence of loneliness and family related factors associated with loneliness among general population in south India. Materials and Methods: The study employed a crosssectional online survey design. The data was collected in the first phase of the lockdown in 2020 from adults in Southern India. Socio-demographic profile and family related variables were collected using a semistructured proforma. Loneliness was assessed by UCLA loneliness scale. Results: Of 573 total respondents to the survey, aged between 18-65 years, 43% were male and 57% were female. The overall prevalence of loneliness was 63% (358/573). No significant gender differences were observed in the prevalence of loneliness. Family discord was associated with higher rates of loneliness (p less than 0.01). Other factors associated were younger age and being single. Conclusion: Rates of loneliness during the COVID-19 lockdown were high in Southern India. Findings suggest that interventions should prioritize younger people. Increasing social support and improving interpersonal skills, which in turn would help reduce family discord and may reduce the impact of COVID-19 on loneliness.

scholarly journals Patient- and Surgery-Related Factors that Affect Patient-Reported Outcomes after Total Hip Arthroplasty

2018 ◽  
Vol 7 (10) ◽  
pp. 358 ◽  
Author(s):  
Toshiyuki Kawai ◽  
Masanao Kataoka ◽  
Koji Goto ◽  
Yutaka Kuroda ◽  
Kazutaka So ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Activity Score ◽  
Harris Hip Score ◽  
Related Factors ◽  
Ucla Activity Score ◽  
Factors Associated ◽  
Total Hip ◽  
Patient Reported

Patient-reported outcome measures (PROMs) are used to assess satisfaction after total hip arthroplasty (THA); however, the factors that determine these PROMs remain unclear. This study aimed to identify the patient- and surgery-related factors that affect patient satisfaction after THA as indicated by the Oxford Hip Score (OHS). One-hundred-and-twenty patients who underwent primary THA were included. Various patient-related factors, including clinical scores, and surgery-related factors were examined for potential correlations with the OHS at 3, 6, and 12 months post-THA. Univariate regression analysis showed that higher preoperative University of California Los Angeles (UCLA) activity score (p = 0.027) and better preoperative OHS (p = 0.0037) were correlated with better OHS at 3 months post-THA. At 6 months post-THA, the factors associated with better OHS were higher preoperative UCLA activity score (p = 0.039), better preoperative OHS (p = 0.0006), and use of a cemented stem (p = 0.0071). At 12 months post-THA, the factors associated with better OHS were higher preoperative UCLA activity score (p = 0.0075) and better preoperative OHS (p < 0.0001). Multivariate regression analysis showed that the factors significantly correlated with better OHS were female sex (p = 0.011 at 3 months post-THA), osteoarthritis (p = 0.043 at 6 months), higher preoperative OHS (p < 0.001 at 3 and 12 months, p = 0.018 at 6 months), higher preoperative Harris Hip Score (p = 0.001 at 3 months), higher preoperative UCLA activity score (p = 0.0075 at 3 months), and the use of a cemented femoral component (p = 0.012 at 6 months). Patient- and surgery-related factors affecting post-THA PROMs were identified, although the effect of these factors decreased over time.

scholarly journals Radiation Pneumonitis: Old Problem, New Tricks

Cancers ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 222 ◽  
Author(s):  
Varsha Jain ◽  
Abigail Berman
Keyword(s):  
Molecular Mechanisms ◽  
Radiation Pneumonitis ◽  
Lung Ventilation ◽  
Related Factors ◽  
Targeted Interventions ◽  
Factors Associated ◽  
Ventilation Imaging ◽  
Lung Ventilation Imaging ◽  
Major Treatment ◽  
Dose Limiting Toxicity

Radiation therapy is a major treatment modality for management of non-small cell lung cancer. Radiation pneumonitis is a dose limiting toxicity of radiotherapy, affecting its therapeutic ratio. This review presents patient and treatment related factors associated with the development of radiation pneumonitis. Research focusing on reducing the incidence of radiation pneumonitis by using information about lung ventilation, imaging-based biomarkers as well as normal tissue complication models is discussed. Recent advances in our understanding of molecular mechanisms underlying lung injury has led to the development of several targeted interventions, which are also explored in this review.

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