Tracheal intubation with or without a neuromuscular blocking agent for a short surgical procedure in children : Prospective, randomized, double‐blind trial

2021 ◽  
Author(s):  
Sujung Park ◽  
Ji‐Ho Kim ◽  
Jae Chan Bae ◽  
Jeong‐Rim Lee ◽  
Min‐Soo Kim
Keyword(s):  
Tracheal Intubation ◽  
Surgical Procedure ◽  
Blocking Agent ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agent ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial

scholarly journals The tof-guard neuromuscular transmission monitor and its use in horses

1999 ◽  
Vol 29 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Juliana Noda Bechara ◽  
Denise Tabacchi Fantoni ◽  
Paulo Sergio de Moraes Barros ◽  
Elton Rodrigues Migliati ◽  
Marcio Augusto Ferreira ◽  
...  
Keyword(s):  
Surgical Procedure ◽  
Neuromuscular Transmission ◽  
Medical Literature ◽  
Neuromuscular Block ◽  
Blocking Agent ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agent ◽  
Neuromuscular Transmission Monitor ◽  
To Receive ◽  
Neuromuscular Transmission Monitoring

It has been emphasized in the human medical literature, that when using a neuromuscular blocking agent, it is of vital importance the monitoring of the neuromuscular block and that these agents should never be used without it. The purpose of this study was to evaluate the use of the neuromuscular transmission monitor TOF-Guard in horses. Twelve horses were randomly assigned whether to receive pancuronium or atracurium as the neuromuscular blocking agent. All horses were pre-medicated with romifidine, anaesthesia induced with diazepam and ketamine and maintenance with halothane. Abolition of spontaneous ventilation was accomplished by the administration of atracurium or pancuronium. The time from injection of the muscle relaxant agent to the onset of maximum block (T1=0), recovery of T1 to 25% and the recovery of TOF ratio to 0.7 were recorded, as was the time for recovery of T1 from 25 to 75%. It was concluded that it is very important the neuromuscular transmission monitoring during the use of a nondepolarizing neuromuscular blocking agent, since it provides a safer anaesthetic and surgical procedure with the use of adequate dosages and due to the impossibility of a superficialization of the neuromuscular blockade during a surgical procedure. The TOF-Guard showed to be a good option for neuromuscular monitoring in horses.

A Double-Blind Trial of Penbutolol: A New Beta-Receptor Blocking Agent in the Treatment of Angina Pectoris

1976 ◽  
Vol 4 (6) ◽  
pp. 410-417 ◽  
Author(s):  
A K Agarwal ◽  
R C Ahuja ◽  
M Chandra ◽  
N N Gupta ◽  
M Hasan
Keyword(s):  
Angina Pectoris ◽  
Blocking Agent ◽  
Controlled Study ◽  
Double Blind Trial ◽  
Subjective Improvement ◽  
Double Blind ◽  
Dosage Range ◽  
Double Blind Placebo ◽  
Receptor Blocking ◽  
Blind Trial

A double-blind placebo controlled study of angina pectoris with Penbutolol was undertaken in parallel groups in fifty-two patients. The duration of the study was six weeks. The dosage range for Penbutolol was 8 mg to 50 mg per day. Six patients were dropped from the analysis. Seventeen patients (81%) in the Penbutolol series exhibited a 50% reduction in anginal attacks, NTG consumption and subjective improvement. Significant reduction in nitrite intake was observed. Effort tolerance was improved significantly in those receiving penbutolol. Penbutolol was well-tolerated.

Fazadinium - a new neuromuscular blocking agent

1978 ◽  
Vol 16 (23) ◽  
pp. 90-92
Keyword(s):  
Tracheal Intubation ◽  
Endotracheal Intubation ◽  
Blocking Agent ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agent ◽  
Convulsive Therapy ◽  
Muscular Relaxation ◽  
Electro Convulsive Therapy

Fazadinium bromide (Fazadon - Duncan, Flockhart) is a new non-depolarising neuromuscular blocking agent which is intended for both tracheal intubation at the start of surgery and muscular relaxation during the operation. The only available quick-acting drugs, suxamethonium (Anectine; Brevidil M), and suxethonium (Brevidil E) are depolarising agents whose effect cannot be reversed with anticholinesterases; they also occasionally have troublesome unwanted effects, which are well summarised in textbooks. Suxamethonium is used mainly to facilitate endotracheal intubation, bronchoscopy, electro-convulsive therapy and short-lasting surgical or orthopaedic procedures requiring relaxation. Its rapid breakdown prevents persistent block. Longer-acting non-depolarising drugs like tubocurarine, gallamine and pancuronium are used to produce relaxation during surgery.

Neuromuscular blocking agent administration for emergent tracheal intubation is associated with decreased prevalence of procedure-related complications*

2012 ◽  
Vol 40 (6) ◽  
pp. 1808-1813 ◽  
Author(s):  
Susan R. Wilcox ◽  
Edward A. Bittner ◽  
Jonathan Elmer ◽  
Todd A. Seigel ◽  
Nicole Thuy P. Nguyen ◽  
...  
Keyword(s):  
Tracheal Intubation ◽  
Blocking Agent ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agent
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