Age‐related cerebrovascular carbon dioxide reactivity in children with ventricular septal defect younger than 3 years

2020 ◽  
Vol 30 (9) ◽  
pp. 977-983
Author(s):  
Boqun Cui ◽  
Chuan Ou‐Yang ◽  
Siyuan Xie ◽  
Duomao Lin ◽  
Jun Ma
Keyword(s):  
Carbon Dioxide ◽  
Ventricular Septal Defect ◽  
Septal Defect ◽  
Age Related ◽  
Carbon Dioxide Reactivity ◽  
Cerebrovascular Carbon Dioxide Reactivity

High-dose Remifentanil Does Not Impair Cerebrovascular Carbon Dioxide Reactivity in Healthy Male Volunteers

2003 ◽  
Vol 99 (4) ◽  
pp. 834-840 ◽  
Author(s):  
Walter Klimscha ◽  
Roman Ullrich ◽  
Christian Nasel ◽  
Wolfgang Dietrich ◽  
Udo M. Illievich ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
High Dose ◽  
Healthy Male ◽  
Duration Of Action ◽  
Remifentanil Infusion ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Carbon Dioxide Reactivity ◽  
Cerebrovascular Carbon Dioxide Reactivity ◽  
Relative Change

Background Cerebrovascular carbon dioxide reactivity during high-dose remifentanil infusion was investigated in volunteers by measurement of regional cerebral blood flow (rCBF) and mean CBF velocity (CBFv). Methods Ten healthy male volunteers with a laryngeal mask for artificial ventilation received remifentanil at an infusion rate of 2 and 4 microg x kg-1 x min-1 under normocapnia, hypocapnia, and hypercapnia. Stable xenon-enhanced computed tomography and transcranial Doppler ultrasonography of the left middle cerebral artery were used to assess rCBF and mean CBFv, respectively. If required, blood pressure was maintained within baseline values with intravenous phenylephrine to avoid confounding effects of altered hemodynamics. Results Hemodynamic parameters were maintained constant over time. Remifentanil infusion at 2 and 4 microg x kg-1 x min-1 significantly decreased rCBF and mean CBFv. Both rCBF and mean CBFv increased as the arterial carbon dioxide tension increased from hypocapnia to hypercapnia, indicating that cerebrovascular reactivity remained intact. The average slopes of rCBF reactivity were 0.56 +/- 0.27 and 0.49 +/- 0.28 ml. 100 g-1 x min-1 x mmHg-1 for 2 and 4 microg x kg-1 x min-1 remifentanil, respectively (relative change in percent/mmHg: 1.9 +/- 0.8 and 1.6 +/- 0.5, respectively). The average slopes for mean CBFv reactivity were 1.61 +/- 0.95 and 1.54 +/- 0.83 cm x s-1 x mmHg-1 for 2 and 4 microg x kg-1 x min-1 remifentanil, respectively (relative change in percent/mmHg: 1.86 +/- 0.59 and 1.79 +/- 0.59, respectively). Preanesthesia and postanesthesia values of rCBF and mean CBFv did not differ. Conclusion High-dose remifentanil decreases rCBF and mean CBFv without impairing cerebrovascular carbon dioxide reactivity. This, together with its known short duration of action, makes remifentanil a useful agent in the intensive care unit when sedation that can be titrated rapidly is required.

Cerebrovascular carbon dioxide reactivity and conductance in patients awake and under general anesthesia

Neurology ◽  
1976 ◽  
Vol 26 (9) ◽  
pp. 835-835 ◽  
Author(s):  
L. D. ILIFF ◽  
E. ZILKHA ◽  
G. H. DU BOULAY ◽  
J. MARSHALL ◽  
I. F. MOSELEY ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
General Anesthesia ◽  
Carbon Dioxide Reactivity ◽  
Cerebrovascular Carbon Dioxide Reactivity
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