Effects of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing newborn rats

2014 ◽  
Vol 24 (12) ◽  
pp. 1245-1251 ◽  
Author(s):  
Junko Tamiya ◽  
Ryoji Ide ◽  
Masayuki Takahashi ◽  
Chikako Saiki
Keyword(s):  
Newborn Rats ◽  
Spontaneously Breathing

Postnatal development of right atrial injection of capsaicin-induced apneic response in rats

2006 ◽  
Vol 101 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Rurong Wang ◽  
Fadi Xu
Keyword(s):  
Respiratory Failure ◽  
Postnatal Development ◽  
Pulmonary Disease ◽  
Bolus Injection ◽  
Right Atrial ◽  
Newborn Rats ◽  
Respiratory Dysfunction ◽  
Percent Change ◽  
C Fiber ◽  
Spontaneously Breathing

Apnea and respiratory failure often occur in infants with pulmonary disease. Bronchopulmonary C-fiber (PCF)-mediated apnea is an important component of respiratory dysfunction. This study was undertaken to define the postnatal development of PCF-mediated apnea. The experiments were conducted in five groups of anesthetized, tracheotomized, and spontaneously breathing rats with ages at postnatal days P1–3, P7–9, P14–16, P21–23, and P56–58. Right atrial bolus injection of three doses of capsaicin (Cap), equivalent to 2, 4, and 8 μg/kg used previously in 450-g rats, was applied to stimulate PCFs. We found that 1) Cap-induced apneic response [percent change from the baseline expiratory duration (Te) values (ΔTe%)] and the sensitivity of this response (ΔTe%·μg−1) were significantly greater in the rats <P10 than those >P10; 2) the Cap-induced apneas were vagally dependent in all rats tested; and 3) bivagotomy-induced prolongation of Te was much greater in the rats <P10 than those >P10. From these findings we concluded that, compared with the older rats (>P10), the newborn rats have a stronger PCF-mediated respiratory inhibition that may contribute to infants' vulnerability to respiratory failure.

Imidazoline 1 receptor activation preserves respiratory drive in spontaneously breathing newborn rats during dexmedetomidine administration

2017 ◽  
Vol 27 (5) ◽  
pp. 506-515 ◽  
Author(s):  
Nana Sato ◽  
Chikako Saiki ◽  
Junko Tamiya ◽  
Toshio Imai ◽  
Katsuhisa Sunada
Keyword(s):  
Receptor Activation ◽  
Respiratory Drive ◽  
Newborn Rats ◽  
Spontaneously Breathing

Application of stereological analysis of cell volume to isolated myocytes in culture with and without adrenergic innervation

1990 ◽  
Vol 48 (3) ◽  
pp. 416-417
Author(s):  
Jane K. Rosenthal ◽  
Dianne L. Atkins ◽  
William J. Marvin ◽  
Penny A. Krumm
Keyword(s):  
Cardiac Myocytes ◽  
Structural Changes ◽  
Three Dimensional ◽  
Adrenergic Innervation ◽  
Culture Cell ◽  
Serial Sections ◽  
Newborn Rats ◽  
Primary Culture Cell ◽  
Biological Studies ◽  
Cell Volumes

To comprehend structural changes in cardiac myocytes accompanying adrenergic innervation, it is essential that a three dimensional analysis be performed. To date, biological studies which utilize stereological methods have been limited to cells in tissue and in organs. Our laboratory has utilized current stereological techniques for measuring absolute volumes of individual myocytes in primary culture. Cell volumes are calculated for two distinct groups of cells at 96 hours in culture: isolated myocytes and myocytes innervated with adrenergic neurons (Figure 1).Cardiac myocytes are cultured from the ventricular apices of newborn rats. Cells are plated directly onto tissue culture dishes with or without preplated explants from the paravertebral thoracolumbar sympathetic chain. On day four cultures are photographed and marked for one-to-one cell location. Following conventional fixation and embeddment in eponate-12, the cells are relocated and mounted for microtomy. The cells are completely sectioned at 120nm in their parallel orientation to the surface of the dish (Figure 2). Serial sections are collected on formvar coated slotted grids and are recorded in sequence.

Neurodegeneration in newborn rats following general anesthesia

2006 ◽  
Vol 37 (06) ◽  
Author(s):  
P Bittigau ◽  
S Bercker ◽  
T Kerner ◽  
B Bert ◽  
H Fink ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Newborn Rats

HEMMUNG VON TESTOSTERONABHÄNGIGEN DIFFERENZIERUNGSVORGÄNGEN DER MÄNNLICHEN RATTE NACH DER GEBURT

1967 ◽  
Vol 54 (2) ◽  
pp. 227-240 ◽  
Author(s):  
F. Neumann ◽  
J. D. Hahn ◽  
M. Kramer
Keyword(s):  
Sexual Behaviour ◽  
Cyproterone Acetate ◽  
Post Partum ◽  
Sexual Attitude ◽  
Normal Male ◽  
Corpora Lutea ◽  
List Type ◽  
Newborn Rats ◽  
Neonatal Treatment ◽  
Triangular Shape

ABSTRACT Male newborn rats were injected with 2 mg of an antiandrogen (1,2α-methylene-6-chloro-pregna-4,6-dien-17α-ol-3,20-dione-17α-acetate = cyproterone acetate) daily from their 1st to their 14th day of life. The following effects of this treatment were observed in these animals after onset of sexual maturity: 84% of the animals are unable to reproduce. Penis: the frenulum is broadened to a lamina of triangular shape, which almost completely prevents the preputium from being pushed back. These males show a rather insufficient male sexual behaviour towards females in oestrus. After castration and ovar implantation, some of the treated animals show true corpora lutea and at attempts of cohabitation partially female sexual behaviour towards normal male animals. From these results it can be concluded, that differentiation of the penis is not completed at the time of birth. The infertility of the animals may be caused by the penile changes (difficulties with intromission) as well as by the aimless sexual behaviour. This aimless sexual behaviour, the ability to produce true corpora lutea and finally their partially female sexual attitude under the influence of the hormones from the implanted ovaries led to the conclusion, that the above described neonatal treatment apparently inhibited testosterone-depending post partum developments of sexual differentiation in hypothalamic centers.

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