scholarly journals 17q12‐21 risk‐variants influence cord blood immune regulation and multitrigger‐wheeze

2021 ◽  
Author(s):  
Kristina Laubhahn ◽  
Andreas Böck ◽  
Kathrin Zeber ◽  
Sandra Unterschemmann ◽  
Sonja Kunze ◽  
...  
Keyword(s):  
Cord Blood ◽  
Immune Regulation ◽  
Risk Variants

scholarly journals Genetic Link Determining the Maternal-Fetal Circulation of Vitamin D

2021 ◽  
Vol 12 ◽  
Author(s):  
Aparna Sampathkumar ◽  
Karen M. Tan ◽  
Li Chen ◽  
Mary F. F. Chong ◽  
Fabian Yap ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Genetic Risk ◽  
Missense Variant ◽  
Birth Cohort Study ◽  
Nucleotide Polymorphisms ◽  
Gene Encoding ◽  
Risk Variants ◽  
Vitamin D Levels ◽  
Genetic Risk Variants

Vitamin D is an essential micronutrient whose demand is heightened during pregnancy to support the growth of the fetus. Furthermore, the fetus does not produce vitamin D and hence relies exclusively on the supply of maternal vitamin D through the placenta. Vitamin D inadequacy is linked with pregnancy complications and adverse infant outcomes. Hence, early predictive markers of vitamin D inadequacy such as genetic vulnerability are important to both mother and offspring. In this multi-ethnic Asian birth cohort study, we report the first genome-wide association analysis (GWAS) of maternal and fetal vitamin D in circulation. For this, 25-hydroxyvitamin D (25OHD) was measured in the antenatal blood of mothers during mid gestation (n=942), and the cord blood of their offspring at birth (n=812). Around ~7 million single nucleotide polymorphisms (SNPs) were regressed against 25OHD concentrations to identify genetic risk variants. About 41% of mothers had inadequate 25OHD (≤75nmol/L) during pregnancy. Antenatal 25OHD was associated with ethnicity [Malay (Β=−22.32nmol/L, p=2.3×10−26); Indian (Β=−21.85, p=3.1×10−21); reference Chinese], age (Β=0.47/year, p=0.0058), and supplement intake (Β=16.47, p=2.4×10−13). Cord blood 25OHD highly correlated with antenatal vitamin D (r=0.75) and was associated with ethnicity [Malay (Β=−4.44, p=2.2×10−7); Indian (Β=−1.99, p=0.038); reference Chinese]. GWAS analysis identified rs4588, a missense variant in the group-specific component (GC) gene encoding vitamin D binding protein (VDBP), and its defining haplotype, as a risk factor for low antenatal (Β=−8.56/T-allele, p=1.0×10−9) and cord blood vitamin D (Β=−3.22/T-allele, p=1.0×10−8) in all three ethnicities. We also discovered a novel association in a SNP downstream of CYP2J2 (rs10789082), a gene involved in 25-hydroxylation of vitamin D, with vitamin D in pregnant women (Β=−7.68/G-allele, p=1.5×10−8), but not their offspring. As the prevention and early detection of suboptimal vitamin D levels are of profound importance to both mother and offspring’s health, the genetic risk variants identified in this study allow risk assessment and precision in early intervention of vitamin D deficiency.

Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell

2007 ◽  
Vol 108 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Yong Zhao ◽  
Zhihua Huang ◽  
Meirigeng Qi ◽  
Ping Lazzarini ◽  
Theodore Mazzone
Keyword(s):  
Stem Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
T Lymphocyte ◽  
Umbilical Cord Blood ◽  
Immune Regulation ◽  
Blood Stem Cell ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Blood Stem Cell

Abstract #91: Comparison of Cord Blood Insulin in Large-for-Gestational-Age Infants and Appropriate-for-Age Filipino Infants of Nondiabetic Mothers: A Pilot Study

2004 ◽  
Vol 10 ◽  
pp. 31
Author(s):  
Florence M. Amorado-Santos ◽  
Maria Honolina S. Gomez ◽  
Maria Victoria R. Olivares ◽  
Zayda N. Gamilla
Keyword(s):  
Pilot Study ◽  
Cord Blood ◽  
Gestational Age ◽  
Large For Gestational Age ◽  
Blood Insulin
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