scholarly journals Association between maternal ritodrine hydrochloride administration during pregnancy and childhood wheezing up to three years of age: The Japan Environment and Children’s Study

2021 ◽  
Author(s):  
Tsuyoshi Murata ◽  
Hyo Kyozuka ◽  
Shun Yasuda ◽  
Toma Fukuda ◽  
Akiko Yamaguchi ◽  
...  
Keyword(s):  
Ritodrine Hydrochloride

Stability-Indicating Chromatographic Methods for the Investigation of Ritodrine Hydrochloride Stability and Characterization of the Oxidative Degradation Product

2019 ◽  
Vol 57 (8) ◽  
pp. 730-737
Author(s):  
Noha Salem Rashed ◽  
Ola Mostafa Abdallah ◽  
Ahmed El-Olemy ◽  
Asmaa Ibrahim Hosam Eldin
Keyword(s):  
Degradation Product ◽  
Mobile Phase ◽  
Oxidative Degradation ◽  
Hplc Method ◽  
Pharmaceutical Dosage Form ◽  
Chromatographic Methods ◽  
Ritodrine Hydrochloride ◽  
Accuracy And Precision ◽  
Intact Drug

Abstract Two simple and sensitive chromatographic methods were developed and validated for quantitative determination of ritodrine hydrochloride in presence of its oxidative degradation product. The first method depends on densitomeric determination of thin-layer chromatograms of the intact drug in presence of its oxidative degradate. Excellent separation was achieved at 220 nm using a mobile phase of dichloromethane–methanol–glacial acetic acid (15 : 5 : 0.25, v/v/v). The second was an HPLC method, in which efficient separation was carried out on C18 column (150 × 4.6 × 5 μm) using a mobile phase consisting of water: acetonitrile (70,30, v/v) at a flow rate of 1 mL min−1 and UV detection at 220 nm. Beer’s law was obeyed in the range of 0.025–0.3 μg/spot and 5–40 μg mL−1 of the intact drug using the two methods, respectively. The proposed methods were validated according to International Conference on Harmonization guidelines and successfully applied for the determination of ritodrine hydrochloride in bulk powder, laboratory prepared mixtures and pharmaceutical dosage form with good accuracy and precision. The results obtained were compared with those of the reported method and were found to be in good agreement.

Ritodrine Hydrochloride and Preterm Labor

1983 ◽  
Vol 83 (4) ◽  
pp. 537
Author(s):  
Shirley L. Brengman ◽  
Margaret Burns
Keyword(s):  
Preterm Labor ◽  
Ritodrine Hydrochloride

scholarly journals Spectrophotometric Determination of Ritodrine and Isoxsuprine Hydrochlorides Using 4-Aminoantipyrine

2000 ◽  
Vol 83 (6) ◽  
pp. 1440-1445 ◽  
Author(s):  
Hosakere D Revanasiddappa ◽  
Bochhe Gowda Manju
Keyword(s):  
Quantitative Determination ◽  
Rapid Method ◽  
Spectrophotometric Determination ◽  
Dosage Forms ◽  
Oxidizing Agent ◽  
Ritodrine Hydrochloride ◽  
Colored Product

Abstract A simple, accurate, and rapid method for the quantitative determination of ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) in both pure and dosage forms, is described. The method is based on the development of pink colored product as a result of the condensation of 4-aminoantipyrine with phenols in the presence of an alkaline oxidizing agent. The resulting products are measured at 510 nm for both drugs, with molar absorptivities of 0.98 × 104 and 1.20 × 104 L/mol·cm for RTH and ISH, respectively. A study of the effect of commonly associated excipients revealed that they did not cause interference.

Ritodrine Hydrochloride And Preterm Labor

1983 ◽  
Vol 83 (4) ◽  
pp. 537-539
Author(s):  
Shirley L. Brengman ◽  
Margaret Burns
Keyword(s):  
Preterm Labor ◽  
Ritodrine Hydrochloride

Metabolic Effects of Ritodrine Hydrochloride in the Pregnant Sheep

2010 ◽  
Vol 10 (3) ◽  
pp. 403-409 ◽  
Author(s):  
Masuo Akahane ◽  
Seiichiro Fujimoto ◽  
Katsuya Uzuki ◽  
Akira Inagawa ◽  
Keiichiro Sakai ◽  
...  
Keyword(s):  
Metabolic Effects ◽  
Ritodrine Hydrochloride ◽  
Pregnant Sheep
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