Low cord blood vitamin D levels are associated with increased milk sensitization in early childhood

2014 ◽  
Vol 25 (8) ◽  
pp. 767-772 ◽  
Author(s):  
Chih-Yung Chiu ◽  
Tsung-Chieh Yao ◽  
Sue-Hsien Chen ◽  
Ming-Han Tsai ◽  
Yu-Ling Tu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Early Childhood ◽  
Cord Blood ◽  
Vitamin D Levels

scholarly journals Cord Blood Vitamin D Levels and Early Childhood Blood Pressure: The Healthy Start Study

2019 ◽  
Vol 8 (9) ◽  
Author(s):  
Katherine A. Sauder ◽  
Alexandra V. Stamatoiu ◽  
Elina Leshchinskaya ◽  
Brandy M. Ringham ◽  
Deborah H. Glueck ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Early Childhood ◽  
Cord Blood ◽  
Healthy Start ◽  
Vitamin D Levels

scholarly journals Association of Maternal Vitamin D Deficiency with Early Childhood Caries

2019 ◽  
Vol 98 (5) ◽  
pp. 549-555 ◽  
Author(s):  
R. Singleton ◽  
G. Day ◽  
T. Thomas ◽  
R. Schroth ◽  
J. Klejka ◽  
...  
Keyword(s):  
Vitamin D ◽  
Early Childhood ◽  
Cord Blood ◽  
Early Childhood Caries ◽  
Serum Vitamin ◽  
Small Sample ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Prenatal Visits ◽  
Childhood Caries

Alaska Native (AN) children experience one of the highest reported rates of severe early childhood caries (S-ECC). Serum vitamin D concentrations in AN childbearing women in the Yukon Kuskokwim Delta (YKD) region have decreased since the 1960s to currently low levels, related to a decrease in traditional marine diet. Recent studies suggest an association between prenatal vitamin D (25(OH)D) concentrations in mothers and S-ECC in their infants. We used independent t tests to analyze the influence of prenatal 25(OH)D levels in YKD AN mothers on S-ECC in their children using data collected in the Maternal Organics Monitoring Study (MOMS). Maternal 25(OH)D levels were assessed at prenatal visits and in cord blood. We queried electronic dental records to assess early childhood caries (ECC) status using highest decayed, missing, filled, primary teeth (dmft) scores at 12 to 59 mo of age. We examined prenatal and cord blood for 76 and 57 mother/infant pairs, respectively. Children 12 to 35 mo of age with “deficient” cord blood (25(OH)D <30 nmol/L) had a mean dmft score twice as high as children who were “nondeficient” at birth (9.3 vs. 4.7; P = 0.002). There was no significant difference in mean dmft scores for children aged 36 to 59 mo with deficient versus nondeficient cord blood 25(OH)D (10.9 vs. 8.7 P = 0.14). There was no significant difference in mean dmft scores for children aged 12 to 35 mo whose mothers had “sufficient” versus “insufficient” 25(OH)D during prenatal visits (9.0 vs. 7.4; P = 0.48). In this small sample, children with deficient vitamin D levels in cord blood had a dmft score at 12 to 35 mo 2-fold higher than children with nondeficient cord blood. Maternal 25(OH)D may influence the primary dentition, and improving vitamin D status in pregnant women might affect ECC rates in their infants.

Cord blood vitamin D is correlated with problem solving domain in early childhood neurodevelopment: A Cohort Study on Vitamin D Status and Its Impact during Pregnancy and Childhood in Indonesia

2020 ◽  
Author(s):  
Stephanie Supriadi ◽  
Lani Gumilang ◽  
Djatnika Setiabudi ◽  
Raden Tina Dewi ◽  
Budi Setiabudiawan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Early Childhood ◽  
Cohort Study ◽  
Problem Solving ◽  
Cord Blood ◽  
Neurodevelopmental Outcome ◽  
Mean Value ◽  
Cord Blood Sample ◽  
Term Infants ◽  
Vitamin D Levels

Abstract Fetal vitamin D level is known to influence brain development and subsequent postnatal neurodevelopment, although several studies stated that this correlation remains controversial. We aimed to determine the correlation between cord blood vitamin D level and neurodevelopmental status in the first 1000 days of life. This was a cohort study, located in Sukabumi and Waled districts of West Java, Indonesia, from 2016–2019. Subjects were term infants with no congenital abnormalities, born from pregnant women involved in a previously conducted cohort study. The cord blood sample collected at delivery was used to measure 25 (OH)-vitamin D level. Neurodevelopmental status was examined after the infants reached 6, 12, and 24 months of age using Ages and Stages Questionnaire-3 (ASQ-3). Statistical analysis was performed using rank Spearman’s correlation. Blood samples were collected from 116 subjects. The mean value of vitamin D levels was 16.2 ng/mL (8.0–35.4 ng/mL). As many as 12.9%, 65.5% and 21.6% of newborns had vitamin D deficiency, insufficiency and normal vitamin D levels. The correlation was found between cordblood vitamin D levels and the problem-solving domain at the age of 12 and 24 months old; r = 0.217, and r = 0.414 respectively. Multiple linier regression analysis result showed a decrease problem solving domain score of 0.641 was associated with decreased of vitamin D. Cordblood vitamin D level correlates with infant neurodevelopmental status. Screening of vitamin D level is crucial during pregnancy and early childhood to improve neurodevelopmental outcome.

scholarly journals Correlation between Fecal Calprotectin Levels in Meconium and Vitamin D Levels in Cord Blood: Association with Intestinal Distress

2020 ◽  
Vol 9 (12) ◽  
pp. 4089
Author(s):  
Jae Hoon Jung ◽  
Sook Hyun Park
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Fecal Calprotectin ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Distress Symptoms ◽  
Vitamin D Levels ◽  
National University ◽  
25 Hydroxyvitamin D ◽  
Median Birth Weight

We aimed to investigate the correlation between vitamin D status in cord blood and fecal calprotectin concentrations in meconium, and also find their association with intestinal distress symptoms during the first two weeks of life. Two hundred and twenty-eight newborns were enrolled in the study who were delivered at Kyungpook National University Children’s Hospital between July 2016 and August 2017. The first passed meconium samples were collected for fecal calprotectin analysis. Intestinal distress involved infants with necrotizing enterocolitis (NEC) and other feeding interruption signs. The median gestational age of the population was 37.0 (34.3–38.4) weeks, and the median birth weight was 2635 (2100–3268) g. The median fecal calprotectin levels in meconium were 134.1 (55.6–403.2) μg/g (range: 11.5–2000 μg/g) and the median 25-hydroxyvitamin D (25-OHD) concentrations in cord blood were 21.0 (15.5–28.8) ng/mL. Sixty infants (26.3%) had intestinal distress, including four patients (1.8%) diagnosed as having NEC. Higher fecal calprotectin concentrations (398.2 (131.8–900.2) μg/g vs. 105.6 (39.4–248.5) μg/g, p < 0.001) and lower 25-OHD levels (17.9 (12.8–22.1) ng/mL vs. 23.2 (17.2–33.0) ng/mL, p < 0.001) were found in infants with intestinal distress compared to infants without intestinal distress. The cut-off value was set at 359.8 μg/g with a sensitivity of 0.53 and a specificity of 0.82 for the development of intestinal distress in the first two weeks of life. Serum 25-OHD levels in cord blood were inversely correlated with fecal calprotectin concentrations in meconium.

scholarly journals Racial disparities in cord blood vitamin D levels and its association with small-for-gestational-age infants

2016 ◽  
Vol 36 (8) ◽  
pp. 623-628 ◽  
Author(s):  
T L Seto ◽  
M E Tabangin ◽  
G Langdon ◽  
C Mangeot ◽  
A Dawodu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Racial Disparities ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Vitamin D Levels

scholarly journals Study of correlation between maternal and cord blood vitamin D3 levels

2019 ◽  
Vol 7 (1) ◽  
pp. 20
Author(s):  
Sunil Rai ◽  
Saurav Das ◽  
Shankar Narayan
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Blood Sample ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Blood Levels ◽  
Cord Blood Sample ◽  
Vitamin D Levels

Background: Vitamin D deficiency during pregnancy and in newborn period is common in this country. Vitamin D status of the mother is known to influence the vitamin D levels in the neonate, however how closely the maternal vitamin D level correlates with the cord blood Vitamin D is not clearly understood. To study the correlation between maternal and neonatal serum Vitamin D3 levels by as indicated by cord blood 25(OH)D levels and find out if there is a significant variation of cord blood 25(OH)D levels in Vitamin D sufficient and insufficient mothers.Methods: Healthy pregnant women between 18-45 years of age with no known history of chronic disease or long-term medication, consenting for the study were enrolled. Maternal blood sample was collected in peripartum period, cord blood sample was obtained after delivery from the umbilical cord after clamping. Vitamin D3 levels were measured by RIA and paired maternal and cord blood levels were statistically analyzed.Results: 569 paired samples of maternal and cord blood were analyzed. The mean maternal serum 25(OH)D level was 35.63ng/ml (sd 6.18, range 9.2-39.8) as compared to 13.52ng/ml (sd 3.79, range 7.9-27) for the neonates. 457 of the mothers were found to have sufficient, 101(18%) insufficient and 11(2%) deficient Vitamin D levels as per Endocrinological Society guidelines. In comparison, 535(94%) of the neonates had deficient levels, none of the neonates had sufficient Vitamin D levels, 34(5.99%) had insufficient levels. No significant correlation was found between maternal and neonatal serum vitamin 25(OH)D levels (r=0.007, P=0.85).Conclusions: Maternal and Cord blood serum Vitamin D3 levels were found to be poorly correlated in this study.

scholarly journals Genetic Link Determining the Maternal-Fetal Circulation of Vitamin D

2021 ◽  
Vol 12 ◽  
Author(s):  
Aparna Sampathkumar ◽  
Karen M. Tan ◽  
Li Chen ◽  
Mary F. F. Chong ◽  
Fabian Yap ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Genetic Risk ◽  
Missense Variant ◽  
Birth Cohort Study ◽  
Nucleotide Polymorphisms ◽  
Gene Encoding ◽  
Risk Variants ◽  
Vitamin D Levels ◽  
Genetic Risk Variants

Vitamin D is an essential micronutrient whose demand is heightened during pregnancy to support the growth of the fetus. Furthermore, the fetus does not produce vitamin D and hence relies exclusively on the supply of maternal vitamin D through the placenta. Vitamin D inadequacy is linked with pregnancy complications and adverse infant outcomes. Hence, early predictive markers of vitamin D inadequacy such as genetic vulnerability are important to both mother and offspring. In this multi-ethnic Asian birth cohort study, we report the first genome-wide association analysis (GWAS) of maternal and fetal vitamin D in circulation. For this, 25-hydroxyvitamin D (25OHD) was measured in the antenatal blood of mothers during mid gestation (n=942), and the cord blood of their offspring at birth (n=812). Around ~7 million single nucleotide polymorphisms (SNPs) were regressed against 25OHD concentrations to identify genetic risk variants. About 41% of mothers had inadequate 25OHD (≤75nmol/L) during pregnancy. Antenatal 25OHD was associated with ethnicity [Malay (Β=−22.32nmol/L, p=2.3×10−26); Indian (Β=−21.85, p=3.1×10−21); reference Chinese], age (Β=0.47/year, p=0.0058), and supplement intake (Β=16.47, p=2.4×10−13). Cord blood 25OHD highly correlated with antenatal vitamin D (r=0.75) and was associated with ethnicity [Malay (Β=−4.44, p=2.2×10−7); Indian (Β=−1.99, p=0.038); reference Chinese]. GWAS analysis identified rs4588, a missense variant in the group-specific component (GC) gene encoding vitamin D binding protein (VDBP), and its defining haplotype, as a risk factor for low antenatal (Β=−8.56/T-allele, p=1.0×10−9) and cord blood vitamin D (Β=−3.22/T-allele, p=1.0×10−8) in all three ethnicities. We also discovered a novel association in a SNP downstream of CYP2J2 (rs10789082), a gene involved in 25-hydroxylation of vitamin D, with vitamin D in pregnant women (Β=−7.68/G-allele, p=1.5×10−8), but not their offspring. As the prevention and early detection of suboptimal vitamin D levels are of profound importance to both mother and offspring’s health, the genetic risk variants identified in this study allow risk assessment and precision in early intervention of vitamin D deficiency.

scholarly journals Cord blood 25-hydroxy Vitamin D and Fluoride in newborn with congenital anomalies

2020 ◽  
Vol 11 (3) ◽  
pp. 17-21
Author(s):  
Abhra Ghosh ◽  
Jagriti Bhardwaj
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Congenital Anomalies ◽  
Pearson Correlation ◽  
Hypovitaminosis D ◽  
Causative Factor ◽  
Group I ◽  
Vitamin D Levels ◽  
Pearson Correlation Test ◽  
25 Hydroxy Vitamin D

Background: It is well known that deficiency of 25 - hydroxy Vitamin D can cause various musculoskeletal manifestations as well as metabolic, non-musculoskeletal abnormalities. There may be a chance that hypovitaminosis D can act as a causative factor for congenital anomalies. Aims and Objectives: The present study was planned to evaluate the level of 25 - hydroxy Vitamin D in cord blood in cases of congenital anomalies and its association with cord blood fluoride levels in newborns with visible congenital anomalies. Materials and Methods: Thirty newborns with visible congenital anomalies were included in group I and thirty healthy newborns without any congenital anomalies were included group II. Ten mL cord blood was collected from the placental end of umbilical cord immediately after delivery of the baby and serum was separated. Serum 25 - hydroxy Vitamin D and fluoride were analyzed by standard methods. Statistical analysis: Results were expressed as Mean ± SD. Unpaired ‘t’ test and Pearson correlation test were applied. Data were considered to be significant if p < 0.05. Results: Serum 25 - hydroxy Vitamin D levels were significantly decreased in babies with congenital anomalies (p=0.001) and show a significant negative association with fluoride.Anomalies related to central nervous system and musculoskeletal systems had the lowest 25 - hydroxy Vitamin D levels and highest serum fluoride levels than other anomalies of other systems. Conclusion: Fluoride can acts as an inhibitor for activation of calciferol causing a decrease in 25 - hydroxy Vitamin D levels. Thus 25 - hydroxy Vitamin D is an important micronutrient for proper development of the fetus and association of it with excess fluoride can cause congenital anomalies.

scholarly journals P2-319 Cord blood vitamin D levels are associated with early life atopic dermatitis

2011 ◽  
Vol 65 (Suppl 1) ◽  
pp. A310-A311
Author(s):  
G. Wegienka ◽  
S. Havstad ◽  
D. Ownby ◽  
E. Zoratti ◽  
C. C. Johnson
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Cord Blood ◽  
Early Life ◽  
Vitamin D Levels
Sign in / Sign up

Export Citation Format

Share Document