Association between changes in the intrathoracic impedance and ventricular arrhythmias in patients with heart failure

2018 ◽  
Vol 41 (12) ◽  
pp. 1577-1582 ◽  
Author(s):  
Mohammed Osman ◽  
Azza Ahmed ◽  
Hussam Alzubi ◽  
Babikir Kheiri ◽  
Khansa Osman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ventricular Arrhythmias ◽  
Patients With Heart Failure ◽  
Intrathoracic Impedance

Abstract 17311: Ventricular Arrhythmias and Fibrosis in Patients With Heart Failure and Preserved Ejection Fraction

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Natasha Cuk ◽  
Jae H Cho ◽  
Donghee Han ◽  
Joseph E Ebinger ◽  
Eugenio Cingolani
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Cardiac Mri ◽  
Ventricular Arrhythmias ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Preserved Ejection Fraction ◽  
Ventricular Ejection Fraction ◽  
Patients With Heart Failure ◽  
Ventricular Fibrosis

Introduction: Sudden death due to ventricular arrhythmias (VA) is one of the main causes of mortality in patients with heart failure and preserved ejection fraction (HFpEF). Ventricular fibrosis in HFpEF has been suspected as a substrate of VA, but the degree of fibrosis has not been well characterized. Hypothesis: HFpEF patients with increased degree of fibrosis will manifest more VA. Methods: Cedars-Sinai medical records were probed using Deep 6 artificial intelligence data extraction software to identify patients with HFpEF who underwent cardiac magnetic resonance imaging (MRI). MRI of identified patients were reviewed to measure extra-cellular volume (ECV) and degree of fibrosis. Ambulatory ECG monitoring (Ziopatch) of those patients were also reviewed to study the prevalence of arrhythmias. Results: A total of 12 HFpEF patients who underwent cardiac MRI were identified. Patients were elderly (mean age 70.3 ± 7.1), predominantly female (83%), and overweight (mean BMI 32 ± 9). Comorbidities included hypertension (83%), dyslipidemia (75%), and coronary artery disease (67%). Mean left ventricular ejection fraction by echocardiogram was 63 ± 8.7%. QTc as measured on ECG was not significantly prolonged (432 ± 15 ms). ECV was normal in those patients for whom it was available (24.2 ± 3.1, n = 9) with 3/12 patients (25%) demonstrating ventricular fibrosis by MRI (average burden of 9.6 ± 5.9%). Ziopatch was obtained in 8/12 patients (including all 3 patients with fibrosis) and non-sustained ventricular tachycardia (NSVT) was identified in 5/8 (62.5%). One patient with NSVT and without fibrosis on MRI also had a sustained VA recorded. In those patients who had Ziopatch monitoring, there was no association between presence of fibrosis and NSVT (X2 = 0.035, p = 0.85). Conclusions: Ventricular fibrosis was present in 25% of HFpEF patients in this study and NSVT was observed in 62.5% of those patients with HFpEF who had Ziopatch monitoring. The presence of fibrosis by Cardiac MRI was not associated with NSVT in this study; however, the size of the cohort precludes broadly generalizable conclusions about this association. Further investigation is required to better understand the relationship between ventricular fibrosis by MRI and VA in patients with HFpEF.

RyR2 Common Gene Variant G1886S and the Risk of Ventricular Arrhythmias in ICD Patients with Heart Failure

2015 ◽  
Vol 26 (6) ◽  
pp. 656-661 ◽  
Author(s):  
PIETRO FRANCIA ◽  
CARMEN ADDUCI ◽  
LORENZO SEMPRINI ◽  
ROSITA STANZIONE ◽  
ANDREA SERDOZ ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ventricular Arrhythmias ◽  
Gene Variant ◽  
Common Gene ◽  
Patients With Heart Failure

Ambulatory Ventricular Arrhythmias in Patients With Heart Failure Do Not Specifically Predict an Increased Risk of Sudden Death

Circulation ◽  
2000 ◽  
Vol 101 (1) ◽  
pp. 40-46 ◽  
Author(s):  
John R. Teerlink ◽  
Muhammad Jalaluddin ◽  
Susan Anderson ◽  
Marrick L. Kukin ◽  
Eric J. Eichhorn ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sudden Death ◽  
Ventricular Arrhythmias ◽  
Increased Risk ◽  
Patients With Heart Failure

scholarly journals Impact of exercise capacity on the long-term incidence of atrial arrhythmias in heart failure

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tetsuri Sakai ◽  
Atsuhiko Yagishita ◽  
Masahiro Morise ◽  
Susumu Sakama ◽  
Takeshi Ijichi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ventricular Arrhythmias ◽  
Maximal Exercise ◽  
Peak Exercise ◽  
Atrial Arrhythmias ◽  
Patients With Heart Failure ◽  
The Impact ◽  
New Onset

AbstractWe sought to demonstrate the impact of improved peak exercise oxygen consumption (V̇O2) during maximal exercise testing after cardiac rehabilitation (CR) on the incidence of arrhythmias in patients with heart failure (HF). The present study comprised of 220 patients with HF, and peak V̇O2 was examined at 2 and 5 months after CR. Of the 220 patients, 110 (50%) had a low peak V̇O2 of < 14 mL/min/kg at 2 months. The peak V̇O2 improved in 86 of these 110 (78%) patients at 5 months after CR. During a median follow-up of 6 years, the patients with improvement in peak V̇O2, compared to those without peak V̇O2 improvement, had a lower rate of mortality (4% vs. 29%, log-rank, P < 0.001) and HF hospitalization (6 vs. 17%, log-rank, P = 0.044) and a lower incidence of new-onset atrial arrhythmias (9 vs. 27%, log-rank, P = 0.013), with no difference in the incidence of ventricular arrhythmias between groups (1 vs. 4%, log-rank, P = 0.309). The majority of deaths in the patients without an improved peak V̇O2 were because of cardiovascular events (73%), particularly progressive HF (55%). Early detection and management of atrial arrhythmias may improve outcomes in patients without peak V̇O2 improvement after CR.

Monitoring Intrathoracic Impedance with an Implantable Defibrillator Reduces Hospitalizations in Patients with Heart Failure

2009 ◽  
Vol 32 (3) ◽  
pp. 363-370 ◽  
Author(s):  
DOMENICO CATANZARITI ◽  
MAURIZIO LUNATI ◽  
MAURIZIO LANDOLINA ◽  
GABRIELE ZANOTTO ◽  
GABRIELE LONARDI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Implantable Defibrillator ◽  
Patients With Heart Failure ◽  
Intrathoracic Impedance
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