scholarly journals Coexistence of atrioventricular accessory pathways and drug-induced type 1 Brugada pattern

2018 ◽  
Vol 41 (9) ◽  
pp. 1078-1092 ◽  
Author(s):  
Can Hasdemir ◽  
Jimmy Jyh-Ming Juang ◽  
Sedat Kose ◽  
Umut Kocabas ◽  
Mehmet N. Orman ◽  
...  
Keyword(s):  
Drug Induced ◽  
Accessory Pathways ◽  
Brugada Pattern

scholarly journals Functional Bowel Disorders in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern

2020 ◽  
Author(s):  
Anil Sarica ◽  
Serhat Bor ◽  
Mehmet Orman ◽  
Hector Barajas-Martinez ◽  
Jimmy Juang ◽  
...  
Keyword(s):  
Brugada Syndrome ◽  
Control Group ◽  
Functional Bowel Disorders ◽  
Drug Induced ◽  
Co Morbidity ◽  
History Of ◽  
Bowel Disorders ◽  
Or History ◽  
Brugada Pattern

Introduction: Irritable bowel syndrome (IBS) is one of the most widely recognized functional bowel disorders (FBDs) with a genetic component. SCN5A gene and SCN1B loci have been identified in population-based IBS cohorts and proposed to have a mechanistic role in the pathophysiology of IBS. These same genes have been associated with Brugada syndrome (BrS). The present study examines the hypothesis that these two inherited syndromes are linked. Methods and Results: Prevalence of FBDs over a 12 months period were compared between probands with BrS/drug-induced type 1 Brugada pattern (DI-Type1 BrP) (n=148) and a control group (n=124) matched for age, female sex, presence of arrhythmia and co-morbid conditions. SCN5A/SCN1B genes were screened in 88 patients. Prevalence of IBS was 25% in patients with BrS/DI-Type1 BrP and 8.1% in the control group (p=2.34×10−4). On stepwise logistic regression analysis, presence of current and/or history of migraine (OR of 2.75; 95% CI: 1.08 to 6.98; p=0.033) was a predictor of underlying BrS/DI-Type1 BrP among patients with FBDs. We identified 8 putative SCN5A/SCN1B variants in 7 (12.3%) patients with BrS/DI-Type1 BrP and 1 (3.2%) patient in control group. Five out of 8 (62.5%) patients with SCN5A/SCN1B variants had FBDs. Conclusion: IBS is a common co-morbidity in patients with BrS/DI-Type1 BrP. Presence of current and/or history of migraine is a predictor of underlying BrS/DI-Type1 BrP among patients with FBDs. Frequent co-existence of IBS and BrS/DI-Type1 BrP necessitates cautious use of certain drugs among the therapeutic options for IBS that are known to exacerbate the Brugada phenotype.

scholarly journals Recognition and clinical implications of high prevalence of migraine in patients with Brugada syndrome and drug‐induced type 1 Brugada pattern

2020 ◽  
Vol 31 (12) ◽  
pp. 3311-3317
Author(s):  
Can Hasdemir ◽  
Figen Gokcay ◽  
Mehmet N. Orman ◽  
Umut Kocabas ◽  
Serdar Payzin ◽  
...  
Keyword(s):  
Brugada Syndrome ◽  
Clinical Implications ◽  
Drug Induced ◽  
High Prevalence ◽  
Brugada Pattern

Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern

2021 ◽  
Author(s):  
Anil S. Sarica ◽  
Serhat Bor ◽  
Mehmet N. Orman ◽  
Hector Barajas-Martinez ◽  
Jyh-Ming Jimmy Juang ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Brugada Syndrome ◽  
Drug Induced ◽  
Irritable Bowel ◽  
Brugada Pattern

Fulminant Type 1 Diabetes Mellitus Associated with Drug Induced Hypersensitivity Syndrome by Zonisamide (Excegran)

2008 ◽  
Vol 70 (5) ◽  
pp. 482-486
Author(s):  
Ikko KAJIHARA ◽  
Asako ICHIHARA ◽  
Jyunko HIGO ◽  
Masato KIDOU ◽  
Mikio TODAKA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Hypersensitivity Syndrome ◽  
Drug Induced ◽  
Fulminant Type 1 Diabetes ◽  
Fulminant Type

scholarly journals Type 1 Brugada pattern ECG due to supra-therapeutic phenytoin level

2016 ◽  
pp. bcr2016214899 ◽  
Author(s):  
Thein Swe ◽  
Bikash Bhattarai ◽  
Alix Dufresne
Keyword(s):  
Brugada Pattern

P945What is the role of late-potentials determined by signal-averaged ECG in predicting flecainide provocative test in brugada pattern?

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
J Brito ◽  
N Cortez-Dias ◽  
N Nunes-Ferreira ◽  
I Aguiar-Ricardo ◽  
G Silva ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Brugada Syndrome ◽  
Fold Increase ◽  
Diagnostic Study ◽  
Late Potentials ◽  
Qrs Complex ◽  
Provocative Test ◽  
Sudden Cardiac Death Risk ◽  
Brugada Pattern

Abstract Introduction The sudden cardiac death risk in Brugada Syndrome (BrS) is higher in patients with spontaneous type 1 pattern. Brugada diagnosis is also established in patients with induced type 1 morphology after provocative test with intravenous administration with a sodium blocker channel. Nevertheless, this group of patients is known to be at a lower risk of SCD, and their risk stratification is still a matter of discussion.  Late potentials (LP) detected on signal-averaged ECG (SAECG) on the RVOT have been previously proposed as a predictor factor for BrS, even though data is lacking on its value. Purpose To evaluate the association between positive LP (LMS40> 38ms) on SAECG with modified Brugada leads and a positive flecainide test in patients with non-type 1 BrS. Methods Retrospective single-center study of non-type 1 BrS patients referred for the performance of a flecainide provocative test. Patients presenting with spontaneous type 1 morphology were excluded from the study. Study of LP on SAECG with modified leads for Brugada were evaluated before administration of flecainide [2mg/kg (maximum150mg), for 10minutes] with determination of filtered QRS duration (fQRS), root mean square voltage of the last 40ms of the QRS complex (RMS40) and duration of low amplitude signals <40μV of the terminal QRS complex (LMS40). Results 126 patients (47.3 ± 14.1 years, 61.9% males) underwent study with LP SAECG and flecainide test. Among these patients, 7.9% were symptomatic and 16.7% had familiar history of BrS. Flecainide test was positive in 46.8% of patients. In patients with a positive flecainide test, 64.4% presented LMS40 > 38ms whereas LMS40 > 38ms was present in only 46% of those with a negative flecainide test (p = 0.031). The presence of positive LMS40 was a positive predictor for a positive flecainide test, associated with a two-fold increase likelihood in the induction of a Brugada pattern (OR: 2,12; IC95% 1,025-4,392; P = 0,043). There was no association between fQRS or RMS40 and a positive flecainide test (p = NS). fQRS > 114ms and RMS40 <20uV was present in 22% and 61% of patients with a positive flecainide test, respectively. Conclusion In patient with non-type 1 Brugada syndrome, LMS40 > 38ms in SAECG was a predictor for a positive flecainide test, suggesting that this finding could be helpful on the risk stratification of patients undergoing diagnostic study for Brugada syndrome. Abstract Figure. Effect of LMS 40 in flecainide test

Type 1 Brugada pattern exacerbation and 1:1 atrioventricular conduction induced by vernakalant

Heart Rhythm ◽  
2014 ◽  
Vol 11 (5) ◽  
pp. 895-897 ◽  
Author(s):  
Theodoros A. Zografos ◽  
Spiros P. Kourouklis ◽  
Apostolos Katsivas
Keyword(s):  
Atrioventricular Conduction ◽  
Brugada Pattern

Drug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: A report of 3 cases

Pain ◽  
2011 ◽  
Vol 152 (9) ◽  
pp. 2173-2178 ◽  
Author(s):  
Ingeborg M. Noppers ◽  
Marieke Niesters ◽  
Leon P.H.J. Aarts ◽  
Martin C.R. Bauer ◽  
Asbjørn M. Drewes ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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