scholarly journals Bionic Tiger‐Bone Powder Improves Bone Microstructure and Bone Biomechanical Strength of Ovariectomized Rats

2021 ◽  
Author(s):  
Shanwu Ren ◽  
Guangjun Jiao ◽  
Lu Zhang ◽  
Yunhao You ◽  
Yunzhen Chen
Keyword(s):  
Bone Microstructure ◽  
Ovariectomized Rats ◽  
Bone Powder ◽  
Biomechanical Strength

Study and Prediction of Bone Strength of Osteoporosis Model Based on Synchrotron Radiation

2021 ◽  
Author(s):  
Wanyu Li ◽  
Jun Xu ◽  
Shunan Zhang ◽  
Han Guo ◽  
Jianqi Sun ◽  
...  
Keyword(s):  
Finite Element ◽  
Synchrotron Radiation ◽  
Bone Strength ◽  
Lumbar Vertebrae ◽  
Bone Microstructure ◽  
Ovariectomized Rats ◽  
Osteoporotic Bone ◽  
Mineral Density ◽  
Model Based ◽  
Osteoporosis Diagnosis

Abstract Background: As the gold standard for clinical osteoporosis diagnosis, bone mineral density has significant limitations in bone strength assessment and fracture risk prediction. The purpose of this study is to explore a new osteoporotic bone quality evaluation criteria from both diagnosis site selection and bone strength prediction. Methods: Ovariectomized rats with different intensity swimming therapy were investigated in this study. The lumbar vertebrae and femurs of all the rats were scanned by synchrotron radiation computed tomography. Bone microstructure analysis and finite element analysis were combined to obtain bone microstructure parameters and estimated bone strength. And the sensitivity of different skeletal sites to therapy was explored. An elastic network regression model was established to predict bone strength by integrating additional bone microstructure characteristics besides bone mass.Results: Histomorphometry analysis showed that swimming therapy could reduce the risk of osteoporosis of lumbar vertebrae and femur and suggested that the femur might be a more suitable site for osteoporosis diagnosis and efficacy evaluation than the lumbar vertebrae. The average coefficient of determination and average root mean squared error of our predictive model were 0.774 and 0.110. Bland-Altman analysis showed that our model could be a good alternative to the finite element method. Conclusions: The present study developed a machine learning model for prediction of bone strength of osteoporosis model based on synchrotron x-ray imaging and demonstrated that different skeletal sites had different sensitivity to therapy, which is of great significance for the early diagnosis of osteoporosis, the prevention of fractures and the monitoring of therapy.

scholarly journals Beneficial Effects of Total Phenylethanoid Glycoside Fraction Isolated from Cistanche deserticola on Bone Microstructure in Ovariectomized Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Lingling Yang ◽  
Shuqin Ding ◽  
Bo Zhang ◽  
Jingjing Liu ◽  
Yanhong Dong ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Bone Microarchitecture ◽  
Bone Microstructure ◽  
Akt Signaling ◽  
Hplc Method ◽  
Ovariectomized Rats ◽  
Mineral Density ◽  
Phenylethanoid Glycoside ◽  
Beneficial Effects ◽  
Ovx Rats

The present study was designed to estimate the antiosteoporotic activity of total phenylethanoid glycoside fraction isolated from C. deserticola (CDP) on rats induced by ovariectomy (OVX) as well as the related mechanisms. After 3 months of oral administration, the decreased bone mineral density, serum Ca, and P in OVX rats were recovered and the deteriorated trabecular bone microarchitecture was partly improved by CDP (60, 120, and 240 mg/kg) intervention, the activities of bone resorption markers were downregulated, and the bioactive of the bone formation index was upregulated; meanwhile, the content of MDA was declined, and GSH was increased by CDP treatment. Compositionally, 8 phenylethanoid glycoside compounds were identified in CDP, with the total contents quantified as 50.3% by using the HPLC method. Mechanistically, CDP declined the levels of TRAF6, RANKL, and RANK, thus suppressing RANKL/RANK/TRAF6-induced activation of downstream NF-κB and PI3K/AKT signaling pathways and ultimately preventing activities of the key osteoclastogenic proteins of NFAT2 and c-Fos. All of the above data implied that CDP exhibited beneficial effects on bone microstructure in ovariectomized rats, and these effects may be related to the NF-κB and PI3K/AKT signaling pathways which were triggered by the binding of RANKL, RANK, and TRAF6.

Effects of preventive long-term treatment with strontium ranelate and zoledronic acid to ovariectomized rats on bone microstructure

2014 ◽  
Author(s):  
Marta Martin-Fernandez ◽  
Marina Gomez-Chinchon ◽  
David Guede ◽  
Jose Ramon Caeiro ◽  
Manuel Diaz-Curiel ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Strontium Ranelate ◽  
Bone Microstructure ◽  
Term Treatment ◽  
Ovariectomized Rats ◽  
Long Term Treatment

scholarly journals Labisia pumilaPrevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Siti Noor Fathilah ◽  
Shahrum Abdullah ◽  
Norazlina Mohamed ◽  
Ahmad Nazrun Shuid
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Rat Model ◽  
Estrogen Replacement Therapy ◽  
Biomechanical Testing ◽  
Fragility Fractures ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Femoral Strength ◽  
Labisia Pumila ◽  
Biomechanical Strength

Estrogen replacement therapy (ERT) is the main treatment postmenopausal osteoporosis. However, ERT causes serious side effects, such as cancers and thromboembolic problems.Labisia pumila var. alata(LPva) is a herb with potential as an alternative to ERT to prevent complications of osteoporosis, especially fragility fractures. This study was conducted to determine the effects of LPva on the biomechanical strength of femora exposed to osteoporosis due to estrogen deficiency, using the postmenopausal rat model. Thirty-two female rats were randomly divided into four groups: Sham-operated (Sham), ovariectomized control (OVXC), ovariectomized withLabisia pumila var. alata(LP), and ovariectomized with ERT (Premarin) (ERT). The LPva and ERT were administered via oral gavage daily at doses of 17.5 mg/kg and 64.5 μg/kg, respectively. Following two months of treatment, the rats were euthanized, and their right femora were prepared for bone biomechanical testing. The results showed that ovariectomy compromised the femoral strength, while LPva supplementation to the ovariectomized rats improved the femoral strength. Therefore, LPva may be as effective as ERT in preventing fractures due to estrogen-deficient osteoporosis.

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