Application of platelet‐rich fibrin after surgical extraction of the mandibular third molar: a systematic review and meta‐analysis

Review question / Objective: This systematic review aims to compare the effects of different corticosteroids to reduce postoperative inflammatory complications (pain, edema, and trismus) after mandibular third molar surgery by applying a frequentist network meta-analysis approach. To this end, the proposed study will answer the following questions: 1) Among diverse corticosteroids currently available, what is the best preoperative option to control postoperative inflammatory complications? 2) What is the optimal dose and route of administration of corticosteroids prior to mandibular third molar surgery to control the pain, edema, and trismus induced by the surgery? Condition being studied: Inflammatory complications after mandibular third molar surgery (Pain, edema, and trismus).

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Platelet-Rich Fibrin in third molar surgery. Systematic review and meta-analysis protocol

10.1101/2020.05.17.20099549 ◽

2020 ◽

Author(s):

Gaston Salas ◽

Shuheng Lai ◽

Francisca Verdugo-Paiva ◽

Roberto Requena

Keyword(s):

Systematic Review ◽

Wound Healing ◽

Meta Analysis ◽

Grey Literature ◽

Third Molar ◽

Risk Of Bias ◽

Third Molar Surgery ◽

Cochrane Central Register ◽

Eligibility Criteria ◽

Platelet Rich Fibrin

Objective: The objective of this systematic review is to assess the effectiveness and safety of platelet rich fibrin (PRF) in third molar surgery. Data sources: A comprehensive search strategy is meant to be used in an attempt to identify all relevant RCTs, ongoing investigation reported in specialty congresses and trials regardless of language or publication status (published, unpublished, in press, and in progress). Search will be conducted in The Cochrane Central Register of Controlled Trials (CENTRAL); PUBMED; Embase; Lilacs, and also conduct a search through trial registries of the International Clinical Trials Registry Platform (ICTRP), Word Health Organization (WHO) and the ClinicalTrials.gov, US National Institutes of Health (NIH), grey literature search and specialty congress will be reviewed. Eligibility criteria: We will include randomised trials evaluating the effect of PRF on wound healing after third molar surgery. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias using Cochrane 'risk of bias' tool. We will pool the results using meta-analysis and will apply the GRADE system to assess the certainty of the evidence for each outcome. Ethics and dissemination: As researchers will not access information that could lead to the identification of an individual participant, obtaining ethical approval was waived. Keywords: platelet-rich fibrin; third molars; wound healing; systematic review

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A systematic review and meta-analysis on the efficacy of low-level laser therapy in the management of complication after mandibular third molar surgery

Lasers in Medical Science ◽

10.1007/s10103-014-1634-0 ◽

2014 ◽

Vol 30 (6) ◽

pp. 1779-1788 ◽

Cited By ~ 33

Author(s):

W. L. He ◽

F. Y. Yu ◽

C. J. Li ◽

J. Pan ◽

R. Zhuang ◽

...

Keyword(s):

Systematic Review ◽

Laser Therapy ◽

Meta Analysis ◽

Third Molar ◽

Low Level Laser Therapy ◽

Third Molar Surgery ◽

Low Level Laser ◽

Level Laser ◽

Mandibular Third Molar ◽

Mandibular Third Molar Surgery

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