scholarly journals Presumed activated retinal astrocytes and Müller cells in healthy and glaucomatous eyes detected by spectral domain optical coherence tomography

2020 ◽  
Vol 40 (6) ◽  
pp. 738-751
Author(s):  
Hin Cheung ◽  
Brett J King ◽  
Thomas J Gast
Keyword(s):  
Optical Coherence Tomography ◽  
Müller Cells ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Muller Cells ◽  
Retinal Astrocytes

scholarly journals En Face Optical Coherence Tomography of Foveal Microstructure in Full-Thickness Macular Hole: A Model to Study Perifoveal Müller Cells

2015 ◽  
Vol 159 (6) ◽  
pp. 1142-1151.e3 ◽  
Author(s):  
Alexandre Matet ◽  
Maria Cristina Savastano ◽  
Marco Rispoli ◽  
Ciara Bergin ◽  
Alexandre Moulin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Hole ◽  
Müller Cells ◽  
Optical Coherence ◽  
Muller Cells ◽  
Full Thickness ◽  
Full Thickness Macular Hole ◽  
En Face

scholarly journals Human Foveal Cone and Müller Cells Examined by Adaptive Optics Optical Coherence Tomography

2021 ◽  
Vol 10 (11) ◽  
pp. 17
Author(s):  
Shin Kadomoto ◽  
Yuki Muraoka ◽  
Akihito Uji ◽  
Sotaro Ooto ◽  
Kentaro Kawai ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Adaptive Optics ◽  
Müller Cells ◽  
Optical Coherence ◽  
Muller Cells

scholarly journals The role of Müller cells in tractional macular disorders: an optical coherence tomography study and physical model of mechanical force transmission

2019 ◽  
Vol 104 (4) ◽  
pp. 466-472 ◽  
Author(s):  
Andrea Govetto ◽  
Jean-Pierre Hubschman ◽  
David Sarraf ◽  
Marta S Figueroa ◽  
Ferdinando Bottoni ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Optical Coherence Tomography ◽  
Müller Cells ◽  
Mechanical Force ◽  
Optical Coherence ◽  
Muller Cells ◽  
Force Transmission ◽  
Myopic Foveoschisis ◽  
Macular Holes

BackgroundTo explore the role of foveal and parafoveal Müller cells in the morphology and pathophysiology of tractional macular disorders with a mathematical model of mechanical force transmission.MethodsIn this retrospective observational study, spectral-domain optical coherence tomography images of tractional lamellar macular holes and patients with myopic foveoschisis were reviewed and analysed with a mathematical model of force transmission. Parafoveal z-shaped Müller cells were modelled as a structure composed of three rigid rods, named R1, R2 and R3. The angle formed between the rods was referred to as θ . R1, R2 and R3 lengths as well as the variation of the angle θ were measured and correlated with best corrected visual acuity (BCVA).ResultsIn tractional lamellar macular holes, there was a significant reduction of the angle θ towards the foveal centre (p<0.001). By contrast, there were no significant differences in θ in myopic foveoschisis (p=0.570). R2 segments were more vertical in myopic foveoschisis. There was a significant association between lower θ angles at 200 µm temporal and nasal to the fovea and lower BCVA (p<0.001 and p=0.005, respectively). The stiffness of parafoveal Müller cells was predicted to be function of the angle θ , and it grew very rapidly as the θ decreased.ConclusionParafoveal Müller cells in the Henle fibre layer may guarantee structural stability of the parafovea by increasing retinal compliance and resistance to mechanical stress. Small values of the angle θ were related to worse BCVA possibly due to damage to Müller cell processes and photoreceptor’s axons.

scholarly journals Two different populations of Müller cells stabilize the structure of the fovea: an optical coherence tomography study

2020 ◽  
Vol 40 (11) ◽  
pp. 2931-2948
Author(s):  
Andreas Bringmann ◽  
Jan Darius Unterlauft ◽  
Renate Wiedemann ◽  
Thomas Barth ◽  
Matus Rehak ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Structural Stability ◽  
Outer Nuclear Layer ◽  
Case Series ◽  
Müller Cells ◽  
Müller Cell ◽  
Optical Coherence ◽  
Muller Cells ◽  
Structural Stabilization ◽  
Muller Cell

Abstract Purpose To document with spectral-domain optical coherence tomography the structural stabilization of the fovea and the sealing of outer macular defects by Müller cells. Methods A retrospective case series of 45 eyes of 34 patients is described. Results In cases of a cystic disruption of the foveola as in macular telangiectasia type 2 and vitreomacular traction, the Müller cell cone provides the structural stability of the fovea. In cases of a detachment or disruption of the Müller cell cone, e.g., in foveal pseudocysts, outer lamellar holes, and degenerative and tractional lamellar holes, Müller cells of the foveal walls may provide the structural stability of the fovea by the formation of a hyperreflective external limiting membrane (ELM) which bridges the holes in the central outer nuclear layer (ONL). Müller cells of the foveal walls and parafovea mediate the regeneration of the foveal architecture in cases of outer lamellar and full-thickness macular holes. The regeneration proceeds by a centripetal displacement of photoreceptor cell somata which closes the holes in the central ONL. The closure may be supported by the formation of a glial tissue band at the ELM which seals the hole. Conclusions The Müller cell cone provides the foveal stability in cases of a cystic disruption of the foveola. The structural stability of the outer foveal layers is mainly provided by the Müller cells of the foveal walls and parafovea; these cells also mediate the regeneration of the outer fovea in cases of a defect of the central ONL.

scholarly journals Extrafoveal Müller cells detection in vivo in the human retina: A pilot study based on optical coherence tomography

2020 ◽  
Vol 199 ◽  
pp. 108183
Author(s):  
Alessandro Arrigo ◽  
Cristian Perra ◽  
Emanuela Aragona ◽  
Daniele Giusto ◽  
Claudio Doglioni ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Pilot Study ◽  
Müller Cells ◽  
Human Retina ◽  
Optical Coherence ◽  
Muller Cells

Is high-resolution spectral domain optical coherence tomography reliable in nystagmus?

2011 ◽  
Vol 97 (4) ◽  
pp. 534.1-536 ◽  
Author(s):  
Mervyn G Thomas ◽  
Anil Kumar ◽  
John R Thompson ◽  
Frank A Proudlock ◽  
Kees Straatman ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Resolution ◽  
Spectral Domain ◽  
Optical Coherence
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