One‐year results of 0.01% atropine with orthokeratology (AOK) study: a randomised clinical trial

2020 ◽  
Vol 40 (5) ◽  
pp. 557-566 ◽  
Author(s):  
Qi Tan ◽  
Alex LK Ng ◽  
Bonnie NK Choy ◽  
George PM Cheng ◽  
Victor CP Woo ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomised Clinical Trial ◽  
One Year

Deferiprone Versus Sequential Deferiprone-Deferoxamine Treatment in Thalassemia Major: A Five Years Multicenter Randomized Clinical Trial under the Auspices of the Society for the Study of Thalassemia and Hemoglobinopathies (SoSTE).

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 575-575 ◽  
Author(s):  
Aurelio Maggio ◽  
Marcello Capra ◽  
Liana Cuccia ◽  
Francesco Gagliardotto ◽  
Carmelo Magnano ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Serum Ferritin ◽  
Statistical Significance ◽  
Thalassemia Major ◽  
Randomised Clinical Trial ◽  
Short Term ◽  
Long Term Study ◽  
One Year

Abstract Three short-term randomised clinical trials suggested not difference of Deferiprone (L1) vs Deferoxamine (DFO) in term of iron overload efficacy in thalassemia major (TM) patients. To assess whether L1 (75mg/Kg) alone was comparable to a sequential treatment using L1 (75mg/Kg) for 4 days and DFO (50mg/Kg) for 3 days, we carried ahead a large long-term randomised clinical trial. One-hundred and forty consecutive patients with TM and serum ferritin between 1,500 and 3,000 ng/ml were randomly assigned to L1 (n°69) or sequential L1-DFO (n°71) and treated for 5 years. The main measure of efficacy was the reduction of serum ferritin levels. Secondary outcomes were liver and heart iron contents assessed by T2* magnetic resonance. After one year-treatment the mean serum feritin reduction was −105 ± 90.4 in L1 and −409 ± 64.2 in sequential L1-DFO treatment (p <0.01), respectively. The greater mean serum ferritin reduction of sequential L1- DFO treatment was also confirmed all over the study (2° year L1 106 ± 713, L1-DFO -321 ± 92 (p <0.01); 3° year L1 137 ± 137, L1-DFO -292 ± 117 (p <0.05); 4° year L1 216 ± 200, L1-DFO-230 ± 170 (p <0.01); 5° year L1 336 ± 244, L1-DFO -598 ± 203 (p <0.01)). After one-year treatment this sequential group showed greater efficacy in term of serum ferritin levels reduction (−409 ± 64.2) in comparison with the DFO alone arm (−232 ± 619) of a previous randomised multicenter clinical trial in which a comparable cohort of patients were studied (p<0.05). Reversible leukocytopenia was shown in 8 (11.5%) L1 and in 7 (9.8%) sequential L1-DFO treated patients. No agranulocythosis was reported on sequential L1-DFO treated patients during the 5 years study. Hypertransaminasemia developed in 13 (18.8%) L1 and in 5 (7%) sequential L1-DFO treated patients. No other major side effects have been reported. Discontinuation of treatment was necessary in 55.6% L1 and in 57.7% sequential L1-DFO treated patients (chi2 0.03, p=0.86). The failures of treatment were less in sequential L1-DFO arm (n°2) in comparison to L1 alone arm (n°8), although this difference not so far reached the statistical significance (chi2 3.4, p=0.06). These findings suggest that sequential L1-DFO treatment in a long-term study is more effective than L1 alone with milder and reversible side effects. Moreover, its efficacy is also higher in comparison with DFO alone at short-term evaluation. Fig. 1 VARIATIONS OF THE FERRITIN LEVELS DURING FIVE YEARS TREATMENT BETWEEN THE TWO ARMS OF THE TRIAL Fig. 1. VARIATIONS OF THE FERRITIN LEVELS DURING FIVE YEARS TREATMENT BETWEEN THE TWO ARMS OF THE TRIAL

scholarly journals Multi-Mode adhesives performance and success/retention rates in NCCLs restorations: randomised clinical trial one-year report

2019 ◽  
Vol 6 (1) ◽  
pp. 43-53
Author(s):  
Patrícia Manarte-Monteiro ◽  
Joana Domingues ◽  
Liliana Teixeira ◽  
Sandra Gavinha ◽  
Maria Conceição Manso
Keyword(s):  
Clinical Trial ◽  
Randomised Clinical Trial ◽  
Retention Rates ◽  
One Year ◽  
Multi Mode

Lifestyle intervention and one-year prognosis of patients following open heart surgery: a randomised clinical trial

2015 ◽  
Vol 24 (11-12) ◽  
pp. 1611-1621 ◽  
Author(s):  
Olga Kadda ◽  
Anastasia Kotanidou ◽  
Athanasios Manginas ◽  
George Stavridis ◽  
Serafim Nanas ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Lifestyle Intervention ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Randomised Clinical Trial ◽  
Open Heart ◽  
One Year

scholarly journals Ahmed Glaucoma Valve Implantation: Graft-Free Short Tunnel Small Flap versus Scleral Patch Graft After 1 Year Follow-Up: A Randomised Clinical Trial

2018 ◽  
Author(s):  
Mohammad Pakravan ◽  
Mohammadmehdi Hatami ◽  
Hamed Esfandiari ◽  
Shahin Yazdani ◽  
Azadeh Doozandeh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intraocular Pressure ◽  
Success Rate ◽  
Randomised Clinical Trial ◽  
Cumulative Probability ◽  
Ahmed Glaucoma Valve ◽  
Patch Graft ◽  
One Year ◽  
Short Tunnel

Purpose: To compare the efficacy and safety of graft-free short tunnel small flap (STSF) technique with that of scleral patch graft (SPG) in Ahmed glaucoma valve (AGV) implantation. &nbsp;Design: Randomized clinical trial. &nbsp;Participants: Eighty-eyes of eighty patients with medically uncontrolled glaucoma including 41 in STSF and 39 eyes in SPG. Methods: Patients were enrolled and assigned randomly to STSF or SPG. &nbsp;Main Outcome Measures: tube exposure, Intraocular pressure (IOP), number of glaucoma medications, best corrected visual acuity (BCVA), surgical complications, and success rate ( defined as intraocular pressure (IOP) &gt;5 mmHg, &le;21 mmHg, and IOP reduction &ge;20% from baseline at two consecutive visits after three months, no reoperation for glaucoma). &nbsp;Results: only one case in SPG developed tube exposure at 1-year follow-up. The cumulative probability of success during the first year of follow-up was 70% in the STSF and 65% in SPG (P = 0.36). IOP decreased significantly from 29.6 &plusmn; 8.6 mmHg at baseline to 16.4 &plusmn; 3.6 mmHg at the final follow-up in STSF (p = 0.001). The corresponding numbers for SPG were 30.9 &plusmn; 11.2 and 15.8 &plusmn; 4.7, respectively (p = 0.001). The final IOP was comparable between both groups (p = 0.65). Mean &plusmn; standard deviation of the number of glaucoma medications was 1.8 &plusmn; 0.9 in STSF and 1.6 &plusmn; 0.9 in SPG at final follow-up (P = 0.32). Postoperative complications developed in 8 patients (19%) in STSF and 9 patients (23%) in SPG (P = 0.81). &nbsp;Conclusions: STSF and SPG techniques had comparable complication rate at one-year follow-up. Both techniques were comparable in terms of success rate, postoperative IOP, and glaucoma medications.

scholarly journals Randomised clinical trial of manipulative therapy and physiotherapy for persistent back and neck complaints: results of one year follow up.

BMJ ◽  
1992 ◽  
Vol 304 (6827) ◽  
pp. 601-605 ◽  
Author(s):  
B. W. Koes ◽  
L. M. Bouter ◽  
H. van Mameren ◽  
A. H. Essers ◽  
G. M. Verstegen ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomised Clinical Trial ◽  
Manipulative Therapy ◽  
One Year
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