scholarly journals Effects of muscarinic agents on chick choroids in intact eyes and eyecups: evidence for a muscarinic mechanism in choroidal thinning

2013 ◽  
Vol 33 (3) ◽  
pp. 245-256 ◽  
Author(s):  
Debora L Nickla ◽  
Xiaoying Zhu ◽  
Josh Wallman
Keyword(s):  
Muscarinic Agents

Gastrin-releasing peptide directly releases pepsinogen from guinea pig chief cells

1990 ◽  
Vol 259 (5) ◽  
pp. G760-G766 ◽  
Author(s):  
S. Fiorucci ◽  
K. E. McArthur
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Receptor Antagonist ◽  
Fold Increase ◽  
Chief Cells ◽  
Gastrin Releasing Peptide ◽  
Basal Release ◽  
Substance P Receptor ◽  
Bombesin Receptor ◽  
Muscarinic Agents

Gastrin-releasing peptide (GRP) and bombesin can stimulate pepsinogen release by both gastrin-dependent and -independent mechanisms. Using isolated guinea pig gastric chief cells, we determined that GRP can act directly on the guinea pig chief cell to cause pepsinogen release. GRP and bombesin stimulated a 2.5- to 3-fold increase in pepsinogen release above basal release. Substance P also stimulated a small but significant increase in pepsinogen release. No gastrin immunoreactivity was detected in the supernatants of cells stimulated with up to 1 microM GRP or bombesin or 1 mM carbachol. GRP-stimulated pepsinogen release was completely inhibited by GRP/bombesin receptor agonists as well as substance P receptor antagonist but not by antagonists to receptors for gastrin, the octapeptide of cholecystokinin (CCK-8), secretin, vasoactive intestinal peptide (VIP), or muscarinic agents. Substance P-stimulated pepsinogen release was completely inhibited by substance P receptor antagonist but not by GRP/bombesin receptor antagonists. An additive effect on pepsinogen release was seen when GRP was combined with maximally effective concentrations of adenosine 3',5'-cyclic monophosphate (cAMP)-mediated agents (VIP, secretin, 8-BrcAMP) but not with calcium-mediated agents (carbachol, CCK-8, gastrin). These results indicate that GRP can directly stimulate pepsinogen release from guinea pig chief cells by a specific GRP receptor that mobilizes intracellular calcium.

Safety of inhaled long-acting anti-muscarinic agents in COPD

2017 ◽  
Vol 129 (5) ◽  
pp. 500-512 ◽  
Author(s):  
Nicola A Hanania ◽  
Suzanne C. Lareau ◽  
Barbara P. Yawn
Keyword(s):  
Long Acting ◽  
Muscarinic Agents

Effects of Muscarinic Agents on Cultured Human Trabecular Meshwork Cells

1996 ◽  
Vol 62 (3) ◽  
pp. 201-210 ◽  
Author(s):  
DEBRA L. SHADE ◽  
ABBOT F. CLARK ◽  
IOK-HOU PANG
Keyword(s):  
Trabecular Meshwork ◽  
Trabecular Meshwork Cells ◽  
Muscarinic Agents

Synthesis of a new series ofN-substituted-3-[l-alkyl(aryl)- 4-piperidyl]azetidin-2-ones as possible muscarinic agents

1993 ◽  
Vol 30 (5) ◽  
pp. 1337-1340 ◽  
Author(s):  
Giorgio Cignarella ◽  
Stefania Villa ◽  
Daniela Barlocco
Keyword(s):  
Alkyl Aryl ◽  
Muscarinic Agents

β-Adrenergic induced K + current in Xenopus oocytes: role of cAMP, inhibition by muscarinic agents

1985 ◽  
Vol 223 (1232) ◽  
pp. 389-402 ◽  
Keyword(s):  
Adenylate Cyclase ◽  
Adrenergic Receptors ◽  
Xenopus Oocytes ◽  
Follicular Cells ◽  
K Current ◽  
Β Adrenergic Receptors ◽  
Cyclase Activator ◽  
Adenylate Cyclase Activator ◽  
Muscarinic Agents

The K + current induced by isoprenaline acting on (β-adrenergic receptors in Xenopus laevis has been studied in oocytes still surrounded by their follicular cells and inner ovarian epithelium. Forskolin, an adenylate cyclase activator, induced a similar K + current and when used at subliminal concentration it potentiated the current induced by isoprenaline. Inhibition of phosphodiesterase by methylisobutylxanthine also en­hanced the response to isoprenaline. 8-Br-cAMP, a permeant analogue of cAMP also produced a K + current. Acetylcholine produced a long lasting inhibition of the isoprenaline current. This inhibition was not seen in the presence of atropine. It is concluded that the K + current induced by the activation of β-adrenergic receptors in the oocyte is mediated by an intracellular rise of cAMP.

Arachidonic acid release by muscarinic agents in cell lines transfected with muscarinic receptors

Life Sciences ◽  
1995 ◽  
Vol 56 (11-12) ◽  
pp. 1016
Author(s):  
F.P. Bymaster ◽  
J.F. Falcone ◽  
H.E. Shannon ◽  
D.O. Calligaro
Keyword(s):  
Arachidonic Acid ◽  
Cell Lines ◽  
Muscarinic Receptors ◽  
Arachidonic Acid Release ◽  
Acid Release ◽  
Muscarinic Agents

scholarly journals Comparison of the effect of anti-muscarinic agents on bladder activity, urinary ATP level, and autonomic nervous system in rats

2009 ◽  
Vol 30 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Saori Nishijima ◽  
Kimio Sugaya ◽  
Katsumi Kadekawa ◽  
Hidekatsu Naka ◽  
Minoru Miyazato
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Atp Level ◽  
Autonomic Nervous ◽  
Bladder Activity ◽  
Muscarinic Agents
Sign in / Sign up

Export Citation Format

Share Document