scholarly journals Role of extracytoplasmic function sigma factor PG1660 (RpoE) in the oxidative stress resistance regulatory network of Porphyromonas gingivalis

2017 ◽  
Vol 33 (1) ◽  
pp. 89-104 ◽  
Author(s):  
Y. Dou ◽  
H. Rutanhira ◽  
X. Chen ◽  
A. Mishra ◽  
C. Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Porphyromonas Gingivalis ◽  
Stress Resistance ◽  
Sigma Factor ◽  
Regulatory Network ◽  
Oxidative Stress Resistance ◽  
Extracytoplasmic Function Sigma Factor

scholarly journals Role of the Porphyromonas gingivalis iron-binding protein PG1777 in oxidative stress resistance

Microbiology ◽  
2016 ◽  
Vol 162 (2) ◽  
pp. 256-267 ◽  
Author(s):  
Rachelle M. E. McKenzie ◽  
Leroy G. Henry ◽  
Marie-Claire Boutrin ◽  
Alexia Ximinies ◽  
Hansel M. Fletcher
Keyword(s):  
Oxidative Stress ◽  
Porphyromonas Gingivalis ◽  
Stress Resistance ◽  
Binding Protein ◽  
Iron Binding ◽  
Oxidative Stress Resistance ◽  
Iron Binding Protein

scholarly journals Role of rgsA in Oxidative Stress Resistance in Pseudomonas aeruginosa

2021 ◽  
Author(s):  
Shuyi Hou ◽  
Jiaqin Zhang ◽  
Xiaobo Ma ◽  
Qiang Hong ◽  
Lili Fang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pseudomonas Aeruginosa ◽  
Stress Resistance ◽  
Oxidative Stress Resistance

scholarly journals Role of AccMGST1 in oxidative stress resistance in Apis cerana cerana

2019 ◽  
Vol 24 (4) ◽  
pp. 793-805 ◽  
Author(s):  
Wenchun Zhao ◽  
Yuzhen Chao ◽  
Ying Wang ◽  
Lijun Wang ◽  
Xinxin Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Resistance ◽  
Apis Cerana ◽  
Apis Cerana Cerana ◽  
Oxidative Stress Resistance

scholarly journals Role of the Porphyromonas gingivalis extracytoplasmic function sigma factor, SigH

2012 ◽  
Vol 27 (3) ◽  
pp. 202-219 ◽  
Author(s):  
S.S. Yanamandra ◽  
S.S. Sarrafee ◽  
C. Anaya-Bergman ◽  
K. Jones ◽  
J.P. Lewis
Keyword(s):  
Porphyromonas Gingivalis ◽  
Sigma Factor ◽  
Extracytoplasmic Function Sigma Factor

scholarly journals Role of the Filifactor alocis Hypothetical Protein FA519 in Oxidative Stress Resistance

2021 ◽  
Author(s):  
Ezinne Aja ◽  
Arunima Mishra ◽  
Yuetan Dou ◽  
Hansel M. Fletcher
Keyword(s):  
Oxidative Stress ◽  
Periodontal Disease ◽  
Stress Resistance ◽  
Hypothetical Protein ◽  
Content Type ◽  
Genetic Tools ◽  
Oxidative Stress Resistance ◽  
Filifactor Alocis ◽  
Diagnostic Indicator

Filifactor alocis is an emerging member of the periodontal community and is now proposed to be a diagnostic indicator of periodontal disease. However, due to the lack of genetic tools available to study this organism, not much is known about its virulence attributes.

The OxrA protein of Aspergillus fumigatus is required for the oxidative stress response and fungal pathogenesis

2021 ◽  
Author(s):  
Pengfei Zhai ◽  
Landan Shi ◽  
Guowei Zhong ◽  
Jihong Jiang ◽  
Jingwen Zhou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Immune Response ◽  
Stress Resistance ◽  
Pathogenic Fungi ◽  
Oxidative Stress Response ◽  
Fungal Pathogenesis ◽  
Oxygen Species ◽  
Oxidative Stress Resistance

An efficient reactive oxygen species (ROS) detoxification system is vital for the survival of the pathogenic fungus Aspergillus fumigatus within the host high ROS environment of the host. Therefore, identifying and targeting factors essential for oxidative stress response is one approach to develop novel treatments for fungal infections. Oxidation resistance 1 (Oxr1) protein is essential for protection against oxidative stress in mammals, but its functions in pathogenic fungi remain unknown. The present study aimed to characterize the role of an Oxr1 homolog in A. fumigatus . The results indicated that the OxrA protein plays an important role in oxidative stress resistance by regulating the catalase function in A. fumigatus , and overexpression of catalase can rescue the phenotype associated with OxrA deficiency. Importantly, the deficiency of oxrA decreased the virulence of A. fumigatus and altered the host immune response. Using the Aspergillus -induced lung infection model, we demonstrated that the ΔoxrA mutant strain induced less tissue damage along with decreased levels of LDH and albumin release. Additionally, the ΔoxrA mutant caused inflammation at a lower degree, along with a markedly reduced influx of neutrophils to the lungs and a decreased secretion of cytokine usually associated with recruitment of neutrophils in mice. These results characterize for the role of OxrA in A. fumigatus , as a core regulator of oxidative stress resistance and fungal pathogenesis. Importance Knowledge of reactive oxygen species (ROS) detoxification in fungal pathogens is useful in the design of new antifungal drugs and could aid in the study of oxidative stress resistance mechanisms. In this study, we demonstrate that OxrA protein localize to the mitochondria and function to protect against oxidative damage. We demonstrate that OxrA contributes to oxidative stress resistance by regulating catalase function, and overexpression of catalase (CatA or CatB) can rescue the phenotype that is associated with OxrA deficiency. Remarkably, a loss of OxrA attenuated the fungal virulence in a mouse model of invasive pulmonary aspergillosis and altered the host immune response. Therefore, our finding indicates that inhibition of OxrA might be an effective approach for alleviating A. fumigatus infection. The present study is, to the best of our knowledge, a pioneer in reporting the vital role of Oxr1 protein in pathogenic fungi.

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