scholarly journals Micro-management: curbing chronic wound infection

2016 ◽  
Vol 32 (4) ◽  
pp. 263-274 ◽  
Author(s):  
C. Withycombe ◽  
K.J. Purdy ◽  
S.E. Maddocks
Keyword(s):  
Wound Infection ◽  
Chronic Wound ◽  
Chronic Wound Infection

scholarly journals Bioengineered Platforms for Chronic Wound Infection Studies: How Can We Make Them More Human-Relevant?

2019 ◽  
Vol 7 ◽  
Author(s):  
Snehal Kadam ◽  
Shivani Nadkarni ◽  
Janhavi Lele ◽  
Savani Sakhalkar ◽  
Pratiksha Mokashi ◽  
...  
Keyword(s):  
Wound Infection ◽  
Chronic Wound ◽  
Chronic Wound Infection

scholarly journals The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection

2020 ◽  
Vol 287 (1937) ◽  
pp. 20202272
Author(s):  
Jelly Vanderwoude ◽  
Derek Fleming ◽  
Sheyda Azimi ◽  
Urvish Trivedi ◽  
Kendra P. Rumbaugh ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Wound Infection ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Morphological Diversity ◽  
Opportunistic Pathogen ◽  
Serial Passage ◽  
Multiple Infection ◽  
Evolution Of Virulence ◽  
Chronic Wound Infection

Opportunistic pathogens are associated with a number of chronic human infections, yet the evolution of virulence in these organisms during chronic infection remains poorly understood. Here, we tested the evolution of virulence in the human opportunistic pathogen Pseudomonas aeruginosa in a murine chronic wound model using a two-part serial passage and sepsis experiment, and found that virulence evolved in different directions in each line of evolution. We also assessed P. aeruginosa adaptation to a chronic wound after 42 days of evolution and found that morphological diversity in our evolved populations was limited compared with that previously described in cystic fibrosis (CF) infections. Using whole-genome sequencing, we found that genes previously implicated in P. aeruginosa pathogenesis ( lasR , pilR , fleQ , rpoN and pvcA ) contained mutations during the course of evolution in wounds, with selection occurring in parallel across all lines of evolution. Our findings highlight that: (i) P. aeruginosa heterogeneity may be less extensive in chronic wounds than in CF lungs; (ii) genes involved in P. aeruginosa pathogenesis acquire mutations during chronic wound infection; (iii) similar genetic adaptations are employed by P. aeruginosa across multiple infection environments; and (iv) current models of virulence may not adequately explain the diverging evolutionary trajectories observed in an opportunistic pathogen during chronic wound infection.

Chronic wound infection: Facts and controversies

2010 ◽  
Vol 28 (5) ◽  
pp. 519-526 ◽  
Author(s):  
Abdul R. Siddiqui ◽  
Jack M. Bernstein
Keyword(s):  
Wound Infection ◽  
Chronic Wound ◽  
Chronic Wound Infection
Sign in / Sign up

Export Citation Format

Share Document