In vitroexpression ofCandida albicansalcohol dehydrogenase genes involved in acetaldehyde metabolism

2014 ◽  
Vol 30 (1) ◽  
pp. 27-38 ◽  
Author(s):  
M.M. Bakri ◽  
A.M. Rich ◽  
R.D. Cannon ◽  
A.R. Holmes
Keyword(s):  
Acetaldehyde Metabolism

scholarly journals Regulation of Alcohol and Acetaldehyde Metabolism by a Mixture of Lactobacillus and Bifidobacterium Species in Human

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1875
Author(s):  
Su-Jin Jung ◽  
Ji-Hyun Hwang ◽  
Eun-Ock Park ◽  
Seung-Ok Lee ◽  
Yun-Jo Chung ◽  
...  
Keyword(s):  
Alcohol Dehydrogenase ◽  
Blood Levels ◽  
Double Blind ◽  
Excessive Alcohol Consumption ◽  
Bifidobacterium Species ◽  
Placebo Capsule ◽  
Safety Parameters ◽  
Excessive Alcohol ◽  
Clinically Significant ◽  
Acetaldehyde Metabolism

Excessive alcohol consumption is one of the most significant causes of morbidity and mortality worldwide. Alcohol is oxidized to toxic and carcinogenic acetaldehyde by alcohol dehydrogenase (ADH) and further oxidized to a non-toxic acetate by aldehyde dehydrogenase (ALDH). There are two major ALDH isoforms, cytosolic and mitochondrial, encoded by ALDH1 and ALDH2 genes, respectively. The ALDH2 polymorphism is associated with flushing response to alcohol use. Emerging evidence shows that Lactobacillus and Bifidobacterium species encode alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) mediate alcohol and acetaldehyde metabolism, respectively. A randomized, double-blind, placebo-controlled crossover clinical trial was designed to study the effects of Lactobacillus and Bifidobacterium probiotic mixture in humans and assessed their effects on alcohol and acetaldehyde metabolism. Here, twenty-seven wild types (ALDH2*1/*1) and the same number of heterozygotes (ALDH2*2/*1) were recruited for the study. The enrolled participants were randomly divided into either the probiotic (Duolac ProAP4) or the placebo group. Each group received a probiotic or placebo capsule for 15 days with subsequent crossover. Primary outcomes were measurement of alcohol and acetaldehyde in the blood after the alcohol intake. Blood levels of alcohol and acetaldehyde were significantly downregulated by probiotic supplementation in subjects with ALDH2*2/*1 genotype, but not in those with ALDH2*1/*1 genotype. However, there were no marked improvements in hangover score parameters between test and placebo groups. No clinically significant changes were observed in safety parameters. These results suggest that Duolac ProAP4 has a potential to downregulate the alcohol and acetaldehyde concentrations, and their effects depend on the presence or absence of polymorphism on the ALDH2 gene.

Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats

2005 ◽  
Vol 1039 (1-2) ◽  
pp. 90-96 ◽  
Author(s):  
Mostofa Jamal ◽  
Kiyoshi Ameno ◽  
Weihuan Wang ◽  
Mitsuru Kumihashi ◽  
Setsuko Ameno ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Acetylcholine Release ◽  
Medial Frontal Cortex ◽  
Freely Moving Rats ◽  
Freely Moving ◽  
Acetaldehyde Metabolism

Effect of a Low-protein Diet on Acetaldehyde Metabolism in Rats

2009 ◽  
Vol 40 (1) ◽  
pp. 134-144 ◽  
Author(s):  
Kai O. Lindros ◽  
Leena Pekkanen ◽  
Timo Koivula
Keyword(s):  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Acetaldehyde Metabolism

ACETALDEHYDE METABOLISM AND LIVER CHANGES IN DOGS MAINTAINED ON A PURIFIED DIET

1949 ◽  
Vol 157 (2) ◽  
pp. 184-192 ◽  
Author(s):  
W. W. Westerfeld ◽  
J. M. McKibbin ◽  
J. C. Roemmelt ◽  
Martin F. Hilfinger
Keyword(s):  
Liver Changes ◽  
Acetaldehyde Metabolism

scholarly journals Acetaldehyde metabolism by rat brain homogenates

1981 ◽  
Vol 31 ◽  
pp. 285
Author(s):  
Eiko Shiohara ◽  
Miyoko Tsukada ◽  
Shigetoshi Chiba
Keyword(s):  
Rat Brain ◽  
Acetaldehyde Metabolism
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