Oral lesions as the only signs of recurrent SARS‐CoV‐2 infection

The aim of this study is to report on the oral lesions detected in 123 patients diagnosed at the University Hospital of Bari from October 2020 to December 2020, focusing on the correlation of clinical and pathological features in order to purpose a new classification. Methods. General and specialistic anamnesis were achieved and oral examination was performed. The following data were collected: age/gender, general symptoms and form of Covid-19, presence and features of taste disorders, day of appearance of the oral lesions, type and features of oral lesions and day of beginning of therapies. If ulcerative lesions did not heal, biopsy was performed. Results. Many types of oral lesions were found and classified into four groups considering the timing of appearance and the start of the therapies. Early lesions in the initial stages of Covid-19 before the start of therapies was observed in 65.9% of the patients. In the histopathological analysis of four early lesions, thrombosis of small and middle size vessels was always noticed with necrosis of superficial tissues. Conclusion. The presence of oral lesions in early stages of Covid-19 could represent an initial sign of peripheral thrombosis, a warning sign of possible evolution to severe illness. This suggests that anticoagulant therapies should start as soon as possible.

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Update on Orofacial Granulomatosis

Primary Dental Journal ◽

10.1177/205016841600500111 ◽

2016 ◽

Vol 5 (1) ◽

pp. 80-85 ◽

Cited By ~ 1

Author(s):

Esther A Hullah ◽

Michael P Escudier

Keyword(s):

Systemic Disease ◽

Granulomatous Inflammation ◽

Bowel Habit ◽

Oral Lesions ◽

Full Thickness ◽

Gastrointestinal Involvement ◽

Orofacial Granulomatosis ◽

Altered Bowel Habit ◽

Systemic Inflammatory Disease ◽

Affected Tissue

Orofacial granulomatosis (OFG) is a condition manifesting clinically with chronic swelling of the mouth and/or face, notably with swelling of the lips and oral mucosa, a full-thickness, erythematous gingivitis and mucosal ulceration of various clinical types.1 Some patients may also present with neurological findings, for example facial palsy. Biopsy of affected tissue shows lymphoedema, with or without granulomatous inflammation. The oral lesions in OFG are histologically indistinguishable from the oral lesions in Crohn's disease (CD) and other systemic granulomatous disorders. It is a condition which may respond to the exclusion of certain food-related chemicals from the diet in up to 60% of patients and, as such, is distinct from gastrointestinal CD.2 CD is a relapsing systemic inflammatory disease which predominantly affects the gut, and patients suffering from this disease frequently present with abdominal pain, fever and altered bowel habit.3 A proportion of patients with clinical OFG (without other systemic disease) may have asymptomatic gastrointestinal involvement or go on to develop gut CD2,4 suggesting an association between the two diseases. It is estimated that 1% of CD sufferers may have a diagnosis of OFG, but the majority of patients in specialist OFG clinics do not have gut symptoms.2

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A Case Report:hand-foot Syndrome Accompanied By Severe Oral Lesions During Capecitabine Therapy For Metastatic Colon Carcinoma

Marmara Medical Journal ◽

10.5472/mmj.2011.01898.2 ◽

2011 ◽

Author(s):

Zehra Asiran Serdar ◽

Isik Gonenc ◽

Sirin Yasar ◽

Tugba Doruk ◽

Nurhan Doner

Keyword(s):

Colon Carcinoma ◽

Oral Lesions ◽

Metastatic Colon Carcinoma

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Development of oral lesions in erythema multiforme exudativum

Oral Surgery Oral Medicine Oral Pathology ◽

10.1016/0030-4220(67)90518-x ◽

1967 ◽

Vol 24 (6) ◽

pp. 808-816 ◽

Cited By ~ 16

Author(s):

James W. Wooten ◽

Harry I. Katz ◽

Seymour Hoffman ◽

Joseph F. Link

Keyword(s):

Erythema Multiforme ◽

Oral Lesions

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