A Genome‐wide Association Study of Premolar Agenesis in a Chinese Population

Oral Diseases ◽  
2021 ◽  
Author(s):  
Liwen Fan ◽  
Lan Ma ◽  
Guirong Zhu ◽  
Siyue Yao ◽  
Xiaofeng Li ◽  
...  
Keyword(s):  
Association Study ◽  
Chinese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association study on photic sneeze reflex in the Chinese population

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mengqiao Wang ◽  
Xinghan Sun ◽  
Yang Shi ◽  
Xiaojun Song ◽  
Hao Mi
Keyword(s):  
Association Study ◽  
Chinese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide association study of COVID-19 severity among the Chinese population

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuanfeng Li ◽  
Yuehua Ke ◽  
Xinyi Xia ◽  
Yahui Wang ◽  
Fanjun Cheng ◽  
...  
Keyword(s):  
Association Study ◽  
Chinese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genetic Determinants ◽  
Asian Populations ◽  
Genetic Components ◽  
Genome Wide ◽  
A Genome ◽  
Meta Analyses

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a broad clinical spectrum of coronavirus disease 2019 (COVID-19). The development of COVID-19 may be the result of a complex interaction between the microbial, environmental, and host genetic components. To reveal genetic determinants of susceptibility to COVID-19 severity in the Chinese population, we performed a genome-wide association study on 885 severe or critical COVID-19 patients (cases) and 546 mild or moderate patients (controls) from two hospitals, Huoshenshan and Union hospitals at Wuhan city in China. We identified two loci on chromosome 11q23.3 and 11q14.2, which are significantly associated with the COVID-19 severity in the meta-analyses of the two cohorts (index rs1712779: odds ratio [OR] = 0.49; 95% confidence interval [CI], 0.38–0.63 for T allele; P = 1.38 × 10−8; and index rs10831496: OR = 1.66; 95% CI, 1.38–1.98 for A allele; P = 4.04 × 10−8, respectively). The results for rs1712779 were validated in other two small COVID-19 cohorts in the Asian populations (P = 0.029 and 0.031, respectively). Furthermore, we identified significant eQTL associations for REXO2, C11orf71, NNMT, and CADM1 at 11q23.3, and CTSC at 11q14.2, respectively. In conclusion, our findings highlight two loci at 11q23.3 and 11q14.2 conferring susceptibility to the severity of COVID-19, which might provide novel insights into the pathogenesis and clinical treatment of this disease.

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