Effect of CD146 + SHED on bone regeneration in a mouse calvaria defect model

Oral Diseases ◽  
2021 ◽  
Author(s):  
Kodai Rikitake ◽  
Ryo Kunimatsu ◽  
Yuki Yoshimi ◽  
Kengo Nakajima ◽  
Tomoka Hiraki ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Defect Model ◽  
Mouse Calvaria

scholarly journals Macrophage Control of Incipient Bone Formation in Diabetic Mice

2021 ◽  
Vol 8 ◽  
Author(s):  
Miya Kang ◽  
Ghadeer Thalji ◽  
Chun-Chieh Huang ◽  
Sajjad Shirazi ◽  
Yu Lu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bone Regeneration ◽  
Mouse Strains ◽  
Hard Tissue ◽  
Defect Model ◽  
Endosseous Implants ◽  
Immunological Responses ◽  
Mouse Calvaria ◽  
Healing Bone

Both soft and hard tissue wound healing are impaired in diabetes. Diabetes negatively impacts fracture healing, bone regeneration and osseointegration of endosseous implants. The complex physiological changes associated with diabetes often manifest in immunological responses to wounding and repair where macrophages play a prominent role in determining outcomes. We hypothesized that macrophages in diabetes contribute toward impaired osseous wound healing. To test this hypothesis, we compared osseous wound healing in the mouse calvaria defect model using macrophages from C57BL/6J and db/db mice to direct osseous repair in both mouse strains. Initial analyses revealed that db/db mice macrophages showed an inflamed phenotype in its resting state. Incipient bone regeneration evaluated by μCT indicated that bone regeneration was relatively impaired in the db/db mouse calvaria and in the calvaria of C57BL/6J mice supplemented with db/db macrophages. Furthermore, osteogenic differentiation of mouse mesenchymal stem cells was negatively impacted by conditioned medium from db/db mice compared to C57BL/6J mice. Moreover, miR-Seq analysis revealed an altered miRNA composition in db/db macrophages with up regulated pro-inflammatory miRNAs and down regulated anti-inflammatory miRNAs. Overall, this study represents a direct step toward understanding macrophage-mediated regulation of osseous bone regeneration and its impairment in type 2 diabetes mellitus.

scholarly journals Bacterial cellulose-hydroxyapatite composites with osteogenic growth peptide (OGP) or pentapeptide OGP on bone regeneration in critical-size calvarial defect model

2015 ◽  
Vol 103 (10) ◽  
pp. 3397-3406 ◽  
Author(s):  
Suzane C. Pigossi ◽  
Guilherme J. P. L. de Oliveira ◽  
Livia S. Finoti ◽  
Rafael Nepomuceno ◽  
Luis Carlos Spolidorio ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bacterial Cellulose ◽  
Critical Size ◽  
Calvarial Defect ◽  
Defect Model

scholarly journals Retraction note: Histopathological features of bone regeneration in a canine segmental ulnar defect model

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Rahim Hobbenaghi ◽  
Pariya Mahboob ◽  
Siamak Saifzadeh ◽  
Javad Javanbakht ◽  
Javad Yaghoobi Yeganeh Manesh ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Defect Model ◽  
Histopathological Features

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

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