The role of IFT140 in early bone healing of tooth extraction sockets

Oral Diseases ◽  
2021 ◽  
Author(s):  
Shuang Zhou ◽  
Gongchen Li ◽  
Tingting Zhou ◽  
Shuai Zhang ◽  
Hui Xue ◽  
...  
Author(s):  
G.A. Murachueva ◽  
I.M. Rasulov ◽  
S.G. Gusenov

A review of the literature on the stages of the formation of temporary and permanent occlusion has been performed. This stages play an important role not only for the full development of the maxillofacial apparatus, temporomandibular joint, but also the whole organism. The role of early tooth extraction in the formation of the physiological state of the dentoalveolar system is considered. The conclusion is drawn about the need for a deeper study of this problem in the structure of general dental morbidity.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Anais Julien ◽  
Anuya Kanagalingam ◽  
Ester Martínez-Sarrà ◽  
Jérome Megret ◽  
Marine Luka ◽  
...  

AbstractBone regenerates by activation of tissue resident stem/progenitor cells, formation of a fibrous callus followed by deposition of cartilage and bone matrices. Here, we show that mesenchymal progenitors residing in skeletal muscle adjacent to bone mediate the initial fibrotic response to bone injury and also participate in cartilage and bone formation. Combined lineage and single-cell RNA sequencing analyses reveal that skeletal muscle mesenchymal progenitors adopt a fibrogenic fate before they engage in chondrogenesis after fracture. In polytrauma, where bone and skeletal muscle are injured, skeletal muscle mesenchymal progenitors exhibit altered fibrogenesis and chondrogenesis. This leads to impaired bone healing, which is due to accumulation of fibrotic tissue originating from skeletal muscle and can be corrected by the anti-fibrotic agent Imatinib. These results elucidate the central role of skeletal muscle in bone regeneration and provide evidence that skeletal muscle can be targeted to prevent persistent callus fibrosis and improve bone healing after musculoskeletal trauma.


2017 ◽  
Vol 32 (3) ◽  
pp. 547-554 ◽  
Author(s):  
Caroline Serrão ◽  
Marta Bastos ◽  
Daniele Cruz ◽  
Fernando Malta ◽  
Paolla Vallim ◽  
...  

2019 ◽  
Vol 30 (S19) ◽  
pp. 88-88
Author(s):  
Jo‐Young Suh ◽  
Kyung Kon Min ◽  
Yong‐Gun Kim ◽  
Jin‐Woo Park ◽  
Jae‐Mok Lee ◽  
...  

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