Interpretation of the mucous plug through sialendoscopy

Oral Diseases ◽  
2021 ◽  
Author(s):  
Massimo Fusconi ◽  
Piero G. Meliante ◽  
Giulio Pagliuca ◽  
Antonio Greco ◽  
Marco de Vincentiis ◽  
...  
Keyword(s):  
Mucous Plug

Mucous Plug in the Bronchus Causing Lung Collapse

2002 ◽  
Vol 347 (14) ◽  
pp. 1079-1079 ◽  
Author(s):  
Suresh R. Nair ◽  
Stanley B. Pearson
Keyword(s):  
Lung Collapse ◽  
Mucous Plug

scholarly journals Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug

1999 ◽  
Vol 338 (2) ◽  
pp. 507-513 ◽  
Author(s):  
John K. SHEEHAN ◽  
Marjorie HOWARD ◽  
Paul S. RICHARDSON ◽  
Toby LONGWILL ◽  
David J. THORNTON
Keyword(s):  
Electron Microscope ◽  
Sequential Extraction ◽  
Gene Product ◽  
Protein S ◽  
Guanidinium Chloride ◽  
Mucus Rheology ◽  
Gel Phase ◽  
Mucous Plug ◽  
Low Charge

We have previously noted that sequential extraction of an asthmatic mucous exudate with 6 M guanidinium chloride yielded a fraction of the mucins that were most resistant to solubilization and of high Mr [Sheehan, Richardson, Fung, Howard and Thornton (1995) Am. J. Respir. Cell Mol. Biol. 13, 748–756]. Here we show that this mucin fraction is dominated (at least 96% of the total) by the low-charge glycoform of the MUC5B gene product. Seen in the electron microscope the mucins appeared mainly as compact ‘island ’ structures composed of linear threads often emanating from globular ‘nodes ’ rather than the discrete linear threads more typical of mucins that we have previously described. The effect of reducing agents was as expected for other gel-forming mucins, i.e. reduced subunits or monomers of Mr 3×106) were produced within 15 min of treatment. Kinetic experiments on the cleavage of the intact mucins with the proteinase trypsin indicated two clear regimes of fragmentation. An initial rapid cleavage generated mucins ranging from Mr = 4×106 to 30×106 that in the electron microscope appeared as polydisperse threads (500–3000 nm in length), similar to normal and other respiratory mucins that we have previously characterized. A subsequent slower fragmentation over many hours yielded a major fragment of Mr 3×106 and length 200–600 nm, very similar in size and Mr to the subunits obtained by reduction. The results suggest that the MUC5B mucin is assembled, first into polydisperse linear threads, which are then linked together via a protein-mediated process. This might involve part of the mucin polypeptide or an as yet unidentified protein(s). The high proteinase susceptibility of the linkage suggests that it might be a point of control for mucin size and thus mucus rheology.

Necrotizing Tracheobronchitis

PEDIATRICS ◽  
1986 ◽  
Vol 78 (6) ◽  
pp. 1168-1168
Author(s):  
F. MIMOUNI ◽  
E. T. BALLARD ◽  
R. T. COTTON ◽  
J. L. BALLARD
Keyword(s):  
The Past ◽  
Mucous Plug ◽  
Necrotizing Tracheobronchitis

In Reply.— We thank Kirpalani et al for their interest in our article1 and their comments. We also read with interest their report,2 which was published while our article was in press, and which confirms that survival is possible after necrotizing tracheobronchitis. Furthermore, we speculate that many "mild" cases of necrotizing tracheobronchitis may have not been recognized in the past, when obstruction was relieved solely by suctioning, and the "mucous plug" was not examined histologically. Treatment of necrotizing tracheobronchitis will probably be the source of controversy in future years.

The Case of the Mucous Plug

1971 ◽  
Vol 6 (6) ◽  
pp. 136-137
Author(s):  
William B. Seaman
Keyword(s):  
Mucous Plug

Airway Obstruction due to Mucous Plug after Endotracheal Intubation in Comatous Patient

1980 ◽  
Vol 13 (4) ◽  
pp. 426
Author(s):  
Nak Seon Kim ◽  
Choul Hong Park ◽  
Inn Se Kim ◽  
Suk Hee Lee
Keyword(s):  
Airway Obstruction ◽  
Endotracheal Intubation ◽  
Mucous Plug

scholarly journals Aveolar Macrophage Activation and Cytokine Storm in the Pathogenesis of Severe COVID-19

2020 ◽  
Author(s):  
Chaofu Wang ◽  
Jing Xie ◽  
Lei Zhao ◽  
Xiaochun Fei ◽  
Heng Zhang ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Clinical Symptoms ◽  
Early Stage ◽  
Gross Anatomy ◽  
The Elderly ◽  
Multiple Organ ◽  
Severe Illness ◽  
Clinical Settings ◽  
The Common ◽  
Mucous Plug

Abstract The coronavirus disease-19 (COVID-19) caused by SARS-CoV-2 infection can lead to a series of clinical settings from non-symptomatic viral carriers/spreaders to severe illness characterized by acute respiratory distress syndrome (ARDS)1,2. A sizable part of patients with COVID-19 have mild clinical symptoms at the early stage of infection, but the disease progression may become quite rapid in the later stage with ARDS as the common manifestation and followed by critical multiple organ failure, causing a high mortality rate of 7-10% in the elderly population with underlying chronic disease1-3. The pathological investigation in the lungs and other organs of fatal cases is fundamental for the mechanistic understanding of severe COVID-19 and the development of specific therapy in these cases. Gross anatomy and molecular markers allowed us to identify, in two fatal patients subject to necropsy, the main pathological features such as exudation and hemorrhage, epithelium injuries, infiltration of macrophages and fibrosis in the lungs. The mucous plug with fibrinous exudate in the alveoli and the activation of alveolar macrophages were characteristic abnormalities. These findings shed new insights into the pathogenesis of COVID-19 and justify the use of interleukin 6 (IL6) receptor antagonists and convalescent plasma with neutralizing antibodies against SARS-CoV-2 for severe patients.Authors Chaofu Wang, Jing Xie, Lei Zhao, Xiaochun Fei, Heng Zhang, and Yun Tan contributed equally to this work. Authors Chaofu Wang, Jun Cai, Rong Chen, Zhengli Shi, and Xiuwu Bian jointly supervised this work.

Unilateral Absence of Ventilation and Perfusion Associated With a Bronchial Mucous Plug

1987 ◽  
Vol 80 (3) ◽  
pp. 391-393 ◽  
Author(s):  
LOWELL E. VEREEN ◽  
D KEITH PAYNE ◽  
RONALD B. GEORGE
Keyword(s):  
Mucous Plug ◽  
Ventilation And Perfusion

Flexible Minibronchoscopy in Children

1987 ◽  
Vol 96 (6) ◽  
pp. 645-649 ◽  
Author(s):  
Robert F. Ward ◽  
James E. Arnold ◽  
Gerald B. Healy
Keyword(s):  
Pediatric Population ◽  
Upper Airway ◽  
Flexible Endoscopy ◽  
Rigid Bronchoscopy ◽  
Upper Aerodigestive Tract ◽  
Treatment Plans ◽  
Tracheal Disease ◽  
Mucous Plug ◽  
Airway Dynamics

Flexible endoscopy is assuming a role of increasing importance in the evaluation and diagnosis of upper aerodigestive tract disorders. With improved fiberoptic capabilities and miniaturization, these techniques are gaining in applicability to the pediatric population. At Children's Hospital, Boston, a newly designed Machida 1.9-mm bronchoscope has been employed in the evaluation of the upper airway. The use of this small caliber instrument has been investigated in 1) evaluation of endotracheal or tracheotomy tube position, thus decreasing the need for repeated chest radiographs to confirm location; 2) bedside evaluation of possible tracheal disease (eg, mucous plug, granuloma, tracheitis) in the intensive care unit patient to determine treatment plans and/or need for further rigid bronchoscopy, and 3) evaluation of airway dynamics in the awake patient. Our experience with the flexible fiberoptic minibronchoscope is reviewed, with a discussion of indications for its use, as well as possible limitations. Case studies are presented to demonstrate the usefulness of the instrument.

The ???Mucous Plug Syndrome??? A Pulmonary Embolism Mimic

1984 ◽  
Vol 9 (9) ◽  
pp. 513-518 ◽  
Author(s):  
STUART T. BRAY ◽  
WILLIAM H. JOHNSTONE ◽  
PAUL M. DEE ◽  
THOMAS L. POPE ◽  
CHARLES D. TEATES ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Mucous Plug

Intestinal obstruction in the newborn due to mucous plug

1931 ◽  
Vol 22 (3) ◽  
pp. 409-415 ◽  
Author(s):  
Frederick H. Falls ◽  
Richard H. Jaffe
Keyword(s):  
Intestinal Obstruction ◽  
Mucous Plug
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