Structural and functional microbial patterns in cohabitating family members with history of periodontitis

Oral Diseases ◽  
2021 ◽  
Author(s):  
Lucía Díaz‐Faes ◽  
Ana Soriano‐Lerma ◽  
Antonio Magan‐Fernandez ◽  
María López ◽  
Juan Gijon ◽  
...  
Keyword(s):  
Family Members ◽  
History Of

New Families with Hereditary Hemorrhagic Trait due to Deficiency of Fibrin Stabilizing Factor (F. XIII)

1968 ◽  
Vol 20 (03/04) ◽  
pp. 534-541 ◽  
Author(s):  
O Egeberg
Keyword(s):  
Factor Xiii ◽  
Family Members ◽  
Recessive Inheritance ◽  
Factor Xiii Deficiency ◽  
History Of ◽  
Congenital Factor

SummarySevere hemorrhagic disorder due to congenital factor XIII deficiency is described in two unrelated Norwegian girls.Plasma cephalin time was for both patients extraordinarily short during episodes of bleeding and hematomas. No such hyperactivity reaction was demonstrable in unaffected condition some months later.Estimations of blood factor XIII levels revealed a partial defect in the parents of both children, and also in some other family members, consistent with an autosomal incompletely recessive inheritance of the defect. Some of the presumptive heterozygotes had a history of light bleeding phenomenons; whether this was related to their partial lack of factor XIII is so far uncertain.

„Denn das Falsche kann echt werden“

2021 ◽  
Vol 46 (1) ◽  
pp. 200-215
Author(s):  
Joachim Seng
Keyword(s):  
Family Background ◽  
Family Members ◽  
Vital Role ◽  
Cultural Setting ◽  
History Of ◽  
Autobiographical Accounts ◽  
Johann Wolfgang Goethe ◽  
Early Influences

Abstract : In his autobiographical accounts, Johann Wolfgang Goethe emphasizes the vital role that his father’s collections of books and art had for his own Bildung. In fact, the library of Johann Caspar Goethe (1710–1782) played a vital role in Goethe’s education and early studies while also attesting to his family background and status. However, soon after Johann Caspar’s death, his library was dissolved – and whereas Johann Wolfgang Goethe and other family members integrated some of the books into their own collections, the majority of objects were sold and dispersed. Today, a handwritten catalog commissioned by Goethe’s mother, Catharina Elisabeth Goethe, just before the sale (in 1793/1794), is a critical tool for reconstructing the collection. This article describes the history of Johann Caspar Goethe’s library, its dispersal as well as the efforts to reconstruct the collection. As the retrieval of the original copies from Johann Caspar’s library and the re-establishment of the original collection were impossible, the Freies Deutsches Hochstift has managed to collect equivalent titles and editions in order to restore a library that allows visitors to the Goethe-Haus in Frankfurt to learn about Goethe’s family background, the cultural setting of his upbringing, and early influences on his education.

scholarly journals Identification of a Novel Missense KRT12 Mutation in a Vietnamese Family with Meesmann Corneal Dystrophy

2020 ◽  
Vol 11 (1) ◽  
pp. 120-126
Author(s):  
Pham Ngoc Dong ◽  
Le Xuan Cung ◽  
Tran Khanh Sam ◽  
Do Thi Thuy Hang ◽  
Doug D. Chung ◽  
...  
Keyword(s):  
Sanger Sequencing ◽  
Novel Mutation ◽  
Family Members ◽  
Corneal Dystrophy ◽  
Slit Lamp ◽  
Slit Lamp Examination ◽  
Corneal Epithelial ◽  
Epithelial Phenotype ◽  
History Of ◽  
Characteristic Features

Meesmann epithelial corneal dystrophy (MECD) is a rare dominantly inherited disorder that is characterized by corneal epithelial microcysts and is associated with mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes. In this study, we report a novel mutation in the KRT12 gene in a Vietnamese pedigree with MECD. Slit-lamp examination was performed on each of the 7 recruited members of a Vietnamese family to identify characteristic features of MECD. After informed consent was obtained from each individual, genomic DNA was isolated from saliva samples and screening of KRT3and KRT12 genes was performed by Sanger sequencing. The proband, a 31-year-old man, complained of a 1-year history of eye irritation and photophobia. Slit-lamp examination revealed intraepithelial microcysts involving only the corneal periphery in each eye with clear central corneas and no stromal or endothelial involvement. Three family members demonstrated similar intraepithelial microcysts, but with diffuse involvement, extended from limbus to limbus. Sanger sequencing of KRT3 (exon 7) and KRT12 (exons 1 and 6) in the proband revealed a novel heterozygous KRT12 variant (c.1273G>A [p.Glu425Lys]) that was present in the three affected family members but was absent in the three family members with clear corneas. This study is the first report of a Vietnamese family affected with MECD, associated with an atypical peripheral corneal epithelial phenotype in the proband and a novel mutation in KRT12.

Familial thrombophilia associated with fibrinogen Paris V: Dusart syndrome

Blood ◽  
2000 ◽  
Vol 96 (3) ◽  
pp. 1191-1193 ◽  
Author(s):  
Takashi Tarumi ◽  
Danko Martincic ◽  
Anne Thomas ◽  
Robert Janco ◽  
Mary Hudson ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Early Onset ◽  
Family Members ◽  
Initial Presentation ◽  
Pulmonary Emboli ◽  
Common Cause ◽  
History Of ◽  
Prophylactic Anticoagulation ◽  
Fibrin Clots

Abstract We report on a family with a history of venous thromboembolism associated with fibrinogen Paris V (fibrinogen A-Arg554→Cys). Ten members experienced thrombotic events, including 4 with fatal pulmonary emboli. Pulmonary embolism was the presenting feature in 4. Those with the mutation and a history of thrombosis had somewhat higher fibrinogen concentrations than those with the mutation and no thrombosis (294 ± 70 mg/dL vs 217 ± 37 mg/dL, respectively). The Paris V mutation consistently caused a prolongation of the reptilase time, and fibrin clots containing the abnormal fibrinogen were more translucent than normal clots. Given the early onset of symptoms and the initial presentation with pulmonary embolism in some family members, it was justifiable to offer prophylactic anticoagulation with warfarin to carriers of the mutation. Fibrinogen Paris V has now been reported in 4 apparently unrelated families, indicating that it is a relatively common cause of dysfibrinogenemia-associated thrombosis.

KOREA'S FIRST-GENERATION DIVIDED FAMILIES: The End of the Line?

World Affairs ◽  
2021 ◽  
pp. 004382002110247
Author(s):  
James Alexander Foley
Keyword(s):  
First Generation ◽  
Korean War ◽  
Family Members ◽  
Red Cross ◽  
Family Separation ◽  
The Korean War ◽  
History Of ◽  
Successes And Failures

This article describes and analyzes the desperate situation of Korean first-generation divided family members who are still separated from their relatives nearly 70 years since the end of the Korean War (1950–1953). I aim to provide the reader with a reasonable quantification of the problem and make projections as to this first generation's likely future survival. The elements of the approach adopted to resolve the issue of family separation by the humanitarian bodies charged with addressing the problem, the Red Cross Societies of the two Koreas are described, and suggestions are made for improvement. The reunion program's successes and failures are critically assessed as is the key role played by the Red Cross Talks in the history of inter-Korean relations. Finally, conclusions are drawn as to the practical measures which may contribute to a resolution to the problem before the final disappearance of Korea's first generation of aged, separated family members.

GENRE OF THE EPISTLE IN THE LYRICS BY M. I. NOVJUKHOV

2021 ◽  
pp. 74-78
Author(s):  
Е.В. Косинцева
Keyword(s):  
Family Members ◽  
Private Life ◽  
Personal Conversation ◽  
History Of

В истории хантыйской литературы к жанру послания обратился только Матвей Иванович Новьюхов. В данной статье анализу подвергаются послания, вошедшие в книгу М.И. Новьюхова «С надеждой на счастье» (2012). Хантыйским поэтом представлены дружеские, любовные послания и послания-письма родным. Диалогическая природа жанра сильнее всего проявилась в дружеских и любовных посланиях хантыйского стихотворца. Диалог с мансийским поэтом Юваном Шесталовым позволил автору размышлять о месте и роли поэта в обществе. М.И. Новьюхов подчеркивает высокое предназначение поэта в жизни общества, не случайно в одном из посланий к основоположнику мансийской литературы он ставит рядом два понятия «поэт» и «гражданин». Частная жизнь и биографические реалии ярче представлены в любовных посланиях и посланиях-письмах к родным. Послания к членам семьи (брату, дочери) носят характер личной беседы. Образцы любовного послания содержит трогательные признания, адресованные возлюбленной. In the history of Khanty literature, only Matvey Ivanovich Novlukhov addressed to the genre of the epistle. The article analyzes the epistles included in the book of M. I. Novjukhov "With Hope For Happiness" (2012). The Khanty poet presents the friendly, love epistles and letters to relatives. The dialogic nature of the genre was most strongly manifested in the friendly and love epistles. The dialogue with the Mansi poet Yuvan Shestalov allowed the author to reflect on the place and role of a poet in society. Novjukhov emphasizes the high purpose of a poet in the life of society. It is no coincidence that in one of the epistles to the founder of Mansi literature, he puts the two concepts of "poet" and "citizen" side by side. Private life and biographical realities are more vividly represented in love epistles and letters to relatives. The epistles to family members (brother, daughter) are in the nature of a personal conversation. Samples of love epistles contain heartwarming declarations of love addressed to his beloved.

scholarly journals HTLV-1 infection is associated with a history of active tuberculosis among family members of HTLV-1-infected patients in Peru

2007 ◽  
Vol 136 (8) ◽  
pp. 1076-1083 ◽  
Author(s):  
K. VERDONCK ◽  
E. GONZÁLEZ ◽  
W. SCHROOTEN ◽  
G. VANHAM ◽  
E. GOTUZZO
Keyword(s):  
Multivariate Analysis ◽  
Index Case ◽  
Family Members ◽  
Active Tuberculosis ◽  
T Lymphotropic Virus ◽  
Lifetime History ◽  
History Of ◽  
Index Cases

SUMMARYThe purpose of this study was to assess the association between human T-lymphotropic virus 1 (HTLV-1) and a lifetime history of active tuberculosis (TB) among relatives of HTLV-1-infected patients. We reviewed clinical charts of all relatives of HTLV-1-infected index cases who attended our institute in Lima from 1990–2004. The data of 1233 relatives was analysed; 394 (32·0%) were HTLV-1 positive. Eighty-one subjects (6·6%) had a history of active TB, including 45/394 (11·4%) HTLV-1-positive and 36/839 (4·3%) HTLV-1-negative relatives (P<0·001). On multivariate analysis, three factors were associated with TB history: HTLV-1 infection (adjusted OR 2·5, 95% CI 1·6–3·9), age (adjusted OR 1·3, 95% CI 1·1–1·5 per 10-year age increase) and relation to the index case (adjusted OR 2·6, 95% CI 1·3–5·1, for siblingsvs. spouses of index cases). In conclusion, HTLV-1 infection may increase the susceptibility to active TB. In populations where both infections are frequent, such an association could affect the dynamics of TB.

scholarly journals Renouncing the World and Taking Ordination

2021 ◽  
Vol 13 (2021/1) ◽  
Author(s):  
Krisztina Teleki
Keyword(s):  
20Th Century ◽  
Dominant Role ◽  
Family Members ◽  
Family Ties ◽  
The Family ◽  
The World ◽  
Monastic Life ◽  
History Of ◽  
Similarities And Differences ◽  
Written Sources

The 20th century brought different periods in the history of Mongolia including theocracy, socialism and democracy. This article describes what renouncing the world (especially the home and the family), taking ordination, and taking monastic vows meant at the turn of the 20th century and a century later. Extracts from interviews reveal the life of pre-novices, illustrating their family backgrounds, connections with family members after ordination, and support from and towards the family. The master-disciple relationship which was of great significance in Vajrayāna tradition, is also described. As few written sources are available to study monks’ family ties, the research was based on interviews recorded with old monks who lived in monasteries in their childhood (prior to 1937), monks who were ordained in 1990, and pre-novices of the current Tantric monastic school of Gandantegčenlin Monastery. The interviews revealed similarities and differences in monastic life in given periods due to historical reasons. Though Buddhism could not attain its previous, absolutely dominant role in Mongolia after the democratic changes, nowadays tradition and innovation exist in parallel.

632 Family History of Children Diagnosed with Obstructive Sleep Apnea

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A248-A248
Author(s):  
Kristi Porterfield-Pruss ◽  
Denise Willis ◽  
Beverly Spray ◽  
Supriya Jambhekar
Keyword(s):  
Family History ◽  
Family Members ◽  
Biological Father ◽  
Medical Problems ◽  
Obstructive Sleep ◽  
Familial Association ◽  
History Of ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship

Abstract Introduction Limited evidence suggests a familial association of OSA. It is not known how often children who require positive airway pressure (PAP) devices have a family member with OSA or that requires PAP. It is felt that PAP adherence in children is affected by PAP adherence in parents. We wanted to explore the relationship of OSA in children requiring PAP to OSA in immediate family members as well as the association of obesity and adherence between children and family members. Methods Caregivers of children who utilize PAP devices at home were invited to complete an electronic questionnaire regarding family history of OSA. Descriptive statistics were utilized to summarize results. Results The study was completed by 75 participants. The majority of children were male (64%, 48/75), black (47%, 35/75) and non-Hispanic (88%, 66/75). The mean age was 11.8 years (median 13) and mean BMI was 32.8 (median 29.8). The mean AHI on the diagnostic polysomnogram was 28.4 events per hour (median 15.3). Mean adherence to PAP &gt; 4 hours per night was 56.5 (Median 68.2). Most, 87% (65/75), have other underlying medical problems. Twenty-four percent (18/75) have a biological father with OSA of whom 61% (11/18) are considered moderately/extremely obese. Of mothers, 13% (10/75) have OSA and 70% (7/10) are obese. Overall, 29% (22/75) had either a paternal (11%, 8/75) or maternal (19%, 14/75) grandfather with OSA of which 36% (8/22) are obese. For grandmothers, 31% (23/75) have OSA and 22% (5/23) are obese with more being paternal (19%, 14/75) compared to maternal (12%, 9/75). Of the 73 total family members reported to have OSA, 86% (63/73) use PAP and most (65%, 41/63) use it for &gt; 4 hours every night. Few participants had siblings with OSA. Conclusion There were more fathers with OSA than mothers, but mothers were reported to be obese more often. Grandparents were reported to have OSA but were reported to be obese less often than parents. Maternal grandparents with OSA were reported to be obese more than paternal grandparents. The majority of family members with OSA who use CPAP report nightly use. Support (if any):

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