Transcriptomic analysis of peripheral blood mononuclear cells in head and neck squamous cell carcinoma patients

Oral Diseases ◽  
2020 ◽  
Author(s):  
Fardeela Bin‐Alee ◽  
Areeya Arayataweegool ◽  
Supranee Buranapraditkun ◽  
Patnarin Mahattanasakul ◽  
Napadon Tangjaturonrasme ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Head and neck squamous cell carcinoma drives long interspersed element‐1 hypomethylation in the peripheral blood mononuclear cells

Oral Diseases ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Areeya Arayataweegool ◽  
Ratakorn Srisuttee ◽  
Patnarin Mahattanasakul ◽  
Napadon Tangjaturonsasme ◽  
Virachai Kerekhanjanarong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Long Interspersed Element

scholarly journals Predictive and prognostic significance of telomerase levels/telomere length in tissues and peripheral blood in head and neck squamous cell carcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Paolo Boscolo-Rizzo ◽  
Enrica Rampazzo ◽  
Jerry Polesel ◽  
Silvia Giunco ◽  
Anna Menegaldo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Telomere Length ◽  
Squamous Cell ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Prognostic Significance ◽  
Response To Therapy ◽  
Neck Squamous Cell Carcinoma

AbstractA growing body of evidence indicates that the expression of TERT, the catalytic subunit of telomerase, is a biological marker of progression in several cancers. We investigated the predictive and prognostic role of TERT levels and telomere length in tissues and peripheral blood in patients with head and neck squamous cell carcinoma (HNSCC). High TERT levels in cancer tissues were independently associated with worse response to therapy (odds ratio [OR]:6.26), regional failure (hazard ratio [HR]:5.75), progression (HR:2.12), and death (HR:3.53). Longer telomeres in the mucosa surrounding the tumor (SM) were independently associated with a lower risk of mucosal failure (HR:0.39). While telomere length in peripheral blood mononuclear cells (PBMC) significantly decreased with age, no correlation was found between age and telomere length in SM. No associations were found between TERT levels in plasma and telomere length in PBMC and the prognostic variables. High levels of TERT transcripts in cancer cells represent a reliable prognostic marker for identifying HNSCC patients with risk of progression. The altered relationship of telomere length to age in SM compared with PBMC suggests that in a subset of cases the phenotypically normal SM constitutes an acquired telomere-shortened epithelial field prone to genetic instability.

Sign in / Sign up

Export Citation Format

Share Document