scholarly journals Intraoral human herpes viruses detectable by PCR in majority of patients

Oral Diseases ◽  
2020 ◽  
Author(s):  
Tami Yap ◽  
Shuan Khor ◽  
Jung Seo Kim ◽  
Jaeyoung Kim ◽  
Sung Yun Kim ◽  
...  
Keyword(s):  
Herpes Viruses ◽  
Human Herpes ◽  
Human Herpes Viruses

Antiviral activity of Colombian Labiatae and Verbenaceae family essential oils and monoterpenes on Human Herpes viruses

2015 ◽  
Vol 28 (2) ◽  
pp. 130-137 ◽  
Author(s):  
Yaneth Miranda Brand ◽  
Vicky Constanza Roa-Linares ◽  
Liliana Amparo Betancur-Galvis ◽  
Diego Camilo Durán-García ◽  
Elena Stashenko
Keyword(s):  
Antiviral Activity ◽  
Essential Oils ◽  
Herpes Viruses ◽  
Human Herpes ◽  
Human Herpes Viruses

Molecular Detection of Human Herpes Viruses in Suspected Measles Serum Samples from Senegal, 2014 to 2017

2021 ◽  
Author(s):  
Mamadou Malado Jallow ◽  
Amary Fall ◽  
Serigne Fallou Wade ◽  
Ndeye Sophie Fall ◽  
Davy Kiori ◽  
...  
Keyword(s):  
Molecular Detection ◽  
Seasonal Pattern ◽  
Clinical Specimen ◽  
Human Herpesvirus ◽  
Case Definition ◽  
Herpes Viruses ◽  
Human Herpes ◽  
Serum Samples ◽  
Cutaneous Lesions ◽  
Human Herpes Viruses

Herpesviruses are known to cause a diversity of clinical syndromes, ranging from minor cutaneous lesions to life-threatening illnesses, especially in immunocompromised hosts. Here, we investigate retrospectively the contribution of five human herpesviruses, including herpes simplex virus Cytomegalovirus (CMV), the Epstein–Barr virus (EBV), human herpesvirus 6, and varicella zoster virus (VZV) in serum samples collected from measles suspected patients with at least fever and rash. Sera specimens were first tested for serological evidence of measles and rubella virus infection by ELISA, and DNA extracted from an aliquot of each clinical specimen for molecular detection of human herpes viruses by RT-qPCR. A total of 3,358 specimens have been collected and tested for herpes viruses. Nearly half of the overall suspected cases were children younger than 5 years (49.4%). Of the 3,358 sera tested by ELISA, 227 (6.7%) were measles laboratory confirmed and 152 (4.5%) rubella laboratory confirmed. Herpes viruses were detected in 1763 (52.5%), and VZV was the most common with 44.3%, followed by EBV with 10.7%. Coinfections were found in 352 (20%) cases, and the most common co-detections were VZV/EBV or VZV/CMV (169 and 81 cases, respectively). A clear seasonal pattern of VZV, EBV, and CMV identification was observed, with the highest incidence between February and April each year. Results of this investigation provide more insights into cutaneous rash syndrome etiologies in patients sampled in the framework of measles/rubella surveillance in Senegal, which is useful for the guidance of both case definition revision and clinical practice as well as for public health policy.

scholarly journals Molecular mechanisms of human herpes viruses inferring with host immune surveillance

2020 ◽  
Vol 8 (2) ◽  
pp. e000841
Author(s):  
Simon Jasinski-Bergner ◽  
Ofer Mandelboim ◽  
Barbara Seliger
Keyword(s):  
Immune Evasion ◽  
Antigen Processing ◽  
Molecular Mechanisms ◽  
Viral Infections ◽  
Immune Surveillance ◽  
Host Cells ◽  
Herpes Viruses ◽  
Molecular Processes ◽  
Human Herpes ◽  
Human Herpes Viruses

Several human herpes viruses (HHVs) exert oncogenic potential leading to malignant transformation of infected cells and/or tissues. The molecular processes induced by viral-encoded molecules including microRNAs, peptides, and proteins contributing to immune evasion of the infected host cells are equal to the molecular processes of immune evasion mediated by tumor cells independently of viral infections. Such major immune evasion strategies include (1) the downregulation of proinflammatory cytokines/chemokines as well as the induction of anti-inflammatory cytokines/chemokines, (2) the downregulation of major histocompatibility complex (MHC) class Ia directly as well as indirectly by downregulation of the components involved in the antigen processing, and (3) the downregulation of stress-induced ligands for activating receptors on immune effector cells with NKG2D leading the way. Furthermore, (4) immune modulatory molecules like MHC class Ib molecules and programmed cell death1 ligand 1 can be upregulated on infections with certain herpes viruses. This review article focuses on the known molecular mechanisms of HHVs modulating the above-mentioned possibilities for immune surveillance and even postulates a temporal order linking regular tumor immunology with basic virology and offering putatively novel insights for targeting HHVs.

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