IGF‐1 TMJ Injections Enhance Mandibular Growth and Bone Quality in Juvenile Rats

2021 ◽  
Author(s):  
Ashwini S. Joshi ◽  
Nan E. Hatch ◽  
Takayuki Hayami ◽  
Andrew Jheon ◽  
Sunil Kapila
Keyword(s):  
Bone Quality ◽  
Juvenile Rats ◽  
Mandibular Growth

Intermittent hypoxia retards mandibular growth and alters RANKL expression in adolescent and juvenile rats

2020 ◽  
Author(s):  
Haixin Hong ◽  
Jun Hosomichi ◽  
Hideyuki Maeda ◽  
Kochakorn Lekvijittada ◽  
Shuji Oishi ◽  
...  
Keyword(s):  
Intermittent Hypoxia ◽  
Bone Growth ◽  
Receptor Activation ◽  
Growth Stages ◽  
Mineral Density ◽  
Juvenile Rats ◽  
Mandibular Growth ◽  
Obstructive Sleep ◽  
Condylar Head ◽  
Adolescent Rats

Summary Objectives Chronic intermittent hypoxia (IH), a common state experienced in obstructive sleep apnoea (OSA), retards mandibular growth in adolescent rats. The aim of this study was to elucidate the differential effects of IH on mandibular growth in different growth stages. Materials and methods Three-week-old (juvenile stage) and 7-week-old (adolescent stage) male Sprague–Dawley rats underwent IH for 3 weeks. Age-matched control rats were exposed to room air. Mandibular growth was evaluated by radiograph analysis, micro-computed tomography, real-time polymerase chain reaction and immunohistology. Tibial growth was evaluated as an index of systemic skeletal growth. Results IH had no significant impact on the general growth of either the juvenile or adolescent rats. However, it significantly decreased the total mandibular length and the posterior corpus length of the mandible in the adolescent rats and the anterior corpus length in the juvenile rats. IH also increased bone mineral density (BMD) of the condylar head in adolescent rats but did not affect the BMD of the tibia. Immunohistological analysis showed that the expression level of receptor activation of nuclear factor-κB ligand significantly decreased (in contrast to its messenger ribonucleicacid level) in the condylar head of adolescent rats with IH, while the number of osteoprotegerin-positive cells was comparable in the mandibles of adolescent IH rats and control rats. Limitations The animal model could not simulate the pathological conditions of OSA completely and there were differences in bone growth between humans and rodents. Conclusions These results suggest that the susceptibility of mandibular growth retardation to IH depends on the growth stage of the rats.

Role of Bone Quality in Osteoporosis Gets Clearer

Ob Gyn News ◽  
2005 ◽  
Vol 40 (10) ◽  
pp. 12
Author(s):  
KERRI WACHTER
Keyword(s):  
Bone Quality

Overweight induced by hypernutrition in juvenile rats dysregulates the central monoamines in the adult age.

2020 ◽  
Author(s):  
Maria Martha Bernardi ◽  
Daclé Juliane Macrini ◽  
Paula da Silva Rodrigues ◽  
Thiago Berti Kirsten ◽  
Gabriela Pena Chaves-Kirsten ◽  
...  
Keyword(s):  
Juvenile Rats ◽  
Adult Age

Clinical and histomorphometrical assessment of bone quality in hip osteoarthritis and osteoporosis

2013 ◽  
Author(s):  
Maurizio Feola ◽  
Cecilia Rao ◽  
Monica Celi ◽  
Elena Gasbarra ◽  
Umberto Tarantino
Keyword(s):  
Bone Quality ◽  
Hip Osteoarthritis

Bone quality in young thalassaemic patients

2013 ◽  
Author(s):  
Alberto Argentiero ◽  
Nadia Agnello ◽  
Cosimo Neglia ◽  
Giovanna Chitano ◽  
Rosa Alessandra Della ◽  
...  
Keyword(s):  
Bone Quality

Bone quality in diabetes mellitus type 2

2014 ◽  
Author(s):  
Peter Jackuliak ◽  
Zdenko Killinger ◽  
Juraj Payer
Keyword(s):  
Diabetes Mellitus ◽  
Bone Quality ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type

Influence of Bone Quality, Drilling Protocol, Implant Diameter/Length on Primary Stability: An In Vitro Comparative Study on Insertion Torque and Resonance Frequency Analysis

2020 ◽  
Vol 46 (3) ◽  
pp. 182-189 ◽  
Author(s):  
Davide Farronato ◽  
Mattia Manfredini ◽  
Michele Stocchero ◽  
Mattia Caccia ◽  
Lorenzo Azzi ◽  
...  
Keyword(s):  
Resonance Frequency ◽  
Bone Quality ◽  
Frequency Analysis ◽  
Primary Stability ◽  
Mean Difference ◽  
Insertion Torque ◽  
Resonance Frequency Analysis ◽  
Bone Response ◽  
Implant Length

The aim of this study was to evaluate the influence of bone quality, drilling technique, implant diameter, and implant length on insertion torque (IT) and resonance frequency analysis (RFA) of a prototype-tapered implant with knife-edge threads. The investigators hypothesized that IT would be affected by variations in bone quality and drilling protocol, whereas RFA would be less influenced by such variables. The investigators implemented an in vitro experiment in which a prototype implant was inserted with different testing conditions into rigid polyurethane foam blocks. The independent variables were: bone quality, drilling protocol, implant diameter, and implant length. Group A implants were inserted with a conventional drilling protocol, whereas Group B implants were inserted with an undersized drilling protocol. Values of IT and RFA were measured at implant installation. IT and RFA values were significantly correlated (Pearson correlation coefficient: 0.54). A multivariable analysis showed a strong model. Higher IT values were associated with drilling protocol B vs A (mean difference: 71.7 Ncm), implant length (3.6 Ncm increase per mm in length), and substrate density (0.199 Ncm increase per mg/cm3 in density). Higher RFA values were associated with drilling protocol B vs A (mean difference: 3.9), implant length (1.0 increase per mm in length), and substrate density (0.032 increase per mg/cm3 in density). Implant diameter was not associated with RFA or IT. Within the limitations of an in vitro study, the results of this study suggest that the studied implant can achieve good level of primary stability in terms of IT and RFA. A strong correlation was found between values of IT and RFA. Both parameters are influenced by the drilling protocol, implant length, and substrate density. Further studies are required to investigate the clinical response in primary stability and marginal bone response.

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