scholarly journals Age‐related change in sedentary behavior during childhood and adolescence: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Elli Kontostoli ◽  
Andy P. Jones ◽  
Natalie Pearson ◽  
Louise Foley ◽  
Stuart J. H. Biddle ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sedentary Behavior ◽  
Meta Analysis ◽  
Childhood And Adolescence ◽  
Age Related

scholarly journals Age-related differences in the error-related negativity and error positivity in children and adolescents: a systematic review and meta-analysis protocol

2020 ◽  
Author(s):  
Rune Boen ◽  
Daniel S Quintana ◽  
Cecile Ladouceur ◽  
Christian K. Tamnes
Keyword(s):  
Systematic Review ◽  
Children And Adolescents ◽  
Literature Search ◽  
Meta Analysis ◽  
Effect Sizes ◽  
Childhood And Adolescence ◽  
Error Related Negativity ◽  
Age Related ◽  
Error Positivity ◽  
Meta Analyses

Background: The error-related negativity (ERN) and the error positivity (Pe) are electrophysiological signals linked to error processing, a crucial aspect of self-monitoring and regulation. Previous research suggests different developmental trajectories for the ERN and Pe, with the ERN increasing in strength during the course of childhood and adolescence, while the Pe appears to reach a plateau by late childhood. There are, however, reports that are discrepant with this pattern, and effects of participant, task and methodological characteristics are poorly understood. The main objectives of this systematic review and meta-analysis are to evaluate the effect of age on ERN and Pe magnitude in children and adolescents, and to examine potential moderators of these effects, including age, sex, experimental task, task difficulty, and topography and quantification of the ERN and Pe. Methods/design: Studies that report group differences between age-groups or associations with age for the ERN and/or Pe magnitude in typically developing children and/or adolescents will be identified. The literature search will be conducted through PubMed and Scopus, all abstracts will be screened, and reference lists of relevant articles cross-checked for inclusion. The present protocol will also be disseminated on social media platforms to call for unpublished data. The data will be extracted from the eligible studies and will be included in random-effect meta-analyses in R. The results will include the estimation of age and age-group effect sizes, heterogeneity, risk of publication bias, and effects of moderating variables. Discussion: The study will include a systematic literature search and meta-analyses to better understand age-related differences in the ERN and Pe magnitudes. The results will provide estimates of effect sizes that are relevant for calculating statistical power and sample sizes for future studies. In addition, it will provide benchmark effect sizes for typical development of the ERN and the Pe that could be used for comparison purposes in developmental studies of clinical or at-risk groups.

scholarly journals Effect of Tai Chi on Markers of Oxidative Stress: Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (7) ◽  
pp. 3458
Author(s):  
Juana Rosado-Pérez ◽  
Osvaldo D. Castelán-Martínez ◽  
Abril J. Mújica-Calderón ◽  
Martha A. Sánchez-Rodríguez ◽  
Víctor Manuel Mendoza-Núñez
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Superoxide Dismutase ◽  
Sedentary Behavior ◽  
Tai Chi ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Stress Markers ◽  
Markers Of Oxidative Stress ◽  
Mean Differences

Background: This study aimed to synthesize the evidence of the effect of practicing Tai Chi on oxidative stress markers (OxSM). Methods: This systematic review and meta-analysis was conducting using the MEDLINE, Cochrane Library, ScienceDirect, Scopus, Epistemonikos, Lilacs, and Ovid databases to identify randomized (RCT) and non-randomized (NRCT) clinical trials that evaluated the Tai Chi effect on OxSM compared to sedentary behavior, walking or yoga. Pooled mean differences (MDs) with 95% confidence intervals (95%CI) were estimated using the inverse variance method to determine the effect of Tai Chi on OxSM. PROSPERO register: CRD42019138362. Results: Five RCT and five NRCT were included. Compared to sedentary behavior, regular Tai Chi practice increases the levels of the enzymes superoxide dismutase (MD = 34.97 U/mL, (95%CI, 9.45 to 60.48), 344 participants) and catalase (MD = 15.63 U/mL, (95%CI, 4.05 to 27.22), 110 participants), as well as reducing the levels of lipoperoxides (MD = −0.02 µmol/L, (95%CI, −0.04 to −0.00), 234 participants). For comparisons with walking or yoga, only one study per activity was identified comparing the effect on OxSM. Conclusions: Regular Tai Chi practice increases the levels of superoxide dismutase and catalase, as well as reducing the levels of lipoperoxides. More studies are necessary to determine the effect of Tai Chi on OxSM when compared to other physical activities.

scholarly journals Establishing reference values for age-related spermatogonial quantity in prepubertal human testes: a systematic review and meta-analysis

2016 ◽  
Vol 106 (7) ◽  
pp. 1652-1657.e2 ◽  
Author(s):  
Ieva Masliukaite ◽  
Julie M. Hagen ◽  
Kirsi Jahnukainen ◽  
Jan-Bernd Stukenborg ◽  
Sjoerd Repping ◽  
...  
Keyword(s):  
Systematic Review ◽  
Reference Values ◽  
Meta Analysis ◽  
Age Related

Comparative effectiveness and harms of intravitreal antivascular endothelial growth factor agents for three retinal conditions: a systematic review and meta-analysis

2018 ◽  
Vol 103 (4) ◽  
pp. 442-451 ◽  
Author(s):  
Allison Low ◽  
Ambar Faridi ◽  
Kavita V Bhavsar ◽  
Glenn C Cockerham ◽  
Michele Freeman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Visual Acuity ◽  
Growth Factor ◽  
Adverse Events ◽  
Meta Analysis ◽  
Diabetic Macular Oedema ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Antivascular Endothelial Growth Factor ◽  
Endothelial Growth Factor

Intravitreal antivascular endothelial growth factor (VEGF) agents are widely used to treat ocular conditions but the benefits and harms of these treatments are uncertain. We conducted a systematic review to compare the effects of aflibercept, bevacizumab and ranibizumab on best-corrected visual acuity (BCVA) changes, quality of life and ocular or systemic adverse events in patients with neovascular age-related macular degeneration (NVAMD), diabetic macular oedema (DME) and central or branch retinal vein occlusion (RVO). We searched published and unpublished literature sources to February 2017 for randomised controlled trials and cohort or modelling studies reporting comparative costs in the USA. Two reviewers extracted data and graded the strength of the evidence using established methods. Of 17 included trials, none reported a clinically important difference (≥ 5 letters) in visual acuity gains between agents. Nine trials provide high-strength evidence of no difference between bevacizumab and ranibizumab for NVAMD. Three trials provide moderate-strength evidence of no difference between bevacizumab and ranibizumab for DME. There was low-strength evidence of similar effects between aflibercept and ranibizumab for NVAMD, aflibercept and bevacizumab for RVO and all three agents for DME. There was insufficient evidence to compare bevacizumab and ranibizumab for RVO. Rates of ocular adverse events were low, and systemic harms were generally similar between groups, although 1 DME trial reported more arterial thrombotic events with ranibizumab versus aflibercept. Overall, no agent had a clear advantage over another for effectiveness or safety. Aflibercept and ranibizumab were significantly less cost-effective than repackaged bevacizumab in two trials. Systematic review registration number: CRD42016034076.

scholarly journals Systematic review and meta-analysis of the association between complementary factor H Y402H polymorphisms and age-related macular degeneration

2006 ◽  
Vol 15 (18) ◽  
pp. 2784-2790 ◽  
Author(s):  
Ammarin Thakkinstian ◽  
Pearline Han ◽  
Mark McEvoy ◽  
Wayne Smith ◽  
Josephine Hoh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Macular Degeneration ◽  
Meta Analysis ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Complementary Factor ◽  
Age Related

scholarly journals Efficacy Comparison of Intravitreal Anti-VEGF Therapy for Three Subtypes of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Jianqing Li ◽  
Jiayi Xu ◽  
Yiyi Chen ◽  
Jiaju Zhang ◽  
Yihong Cao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Macular Degeneration ◽  
Meta Analysis ◽  
Age Related Macular Degeneration ◽  
Cochrane Library ◽  
Anti Vegf ◽  
Age Related ◽  
Significant Difference ◽  
The Mean

Purpose. Intravitreal antivascular endothelial growth factor (anti-VEGF) therapy has been widely used for the treatment of neovascularization (NV) secondary to age-related macular degeneration (AMD). This study aimed to compare the efficacy among different subtypes of neovascular age-related macular degeneration (nAMD). Methods. PubMed, Embase, and the Cochrane Library were searched for eligible studies. We performed meta-analysis using Review Manager 5.3 and Stata/SE 12.0. Results. A total of 24 studies met our inclusion criteria and were included in the systematic review. At 3 months, the mean logarithm of the minimum angle of resolution (logMAR) improvements were −0.09, −0.18, and −0.23 for type 1, 2, and 3, respectively, while the mean macular thickness (MT) changes were −104.83, −130.76, and −196.29 μm. At 12 months, the mean changes in Early Treatment of Diabetic Retinopathy Study (ETDRS) letters were 6.38, 8.12, and 9.37, while the MT decrease was 126.51, 126.52, and 139.85 μm, respectively. However, statistically significant difference was only found between type 1 and 3 in vision improvement, both in the short term (p=0.0002) and long term (p=0.01). Conclusions. The reactivity to VEGF inhibitors varied among different subtypes of nAMD. The efficacy of intravitreal anti-VEGF therapy in type 3 nAMD was statistically better than type 1 when considering vision improvement at 3 and 12 months. Thus, the lesion subtype is a predictor for the treatment outcome which can help guide prognosis.

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