scholarly journals Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature

2020 ◽  
Vol 21 (8) ◽  
Author(s):  
Mikiko Watanabe ◽  
Rossella Tozzi ◽  
Renata Risi ◽  
Dario Tuccinardi ◽  
Stefania Mariani ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Ketogenic Diet ◽  
Fatty Liver Disease ◽  
Review Of The Literature ◽  
Comprehensive Review ◽  
Nonalcoholic Fatty Liver ◽  
Beneficial Effects

scholarly journals Nonalcoholic fatty liver disease and bariatric surgery: a comprehensive review

2017 ◽  
Vol 135 (3) ◽  
pp. 277-295 ◽  
Author(s):  
Everton Cazzo ◽  
José Carlos Pareja ◽  
Elinton Adami Chaim
Keyword(s):  
Bariatric Surgery ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Health Concern ◽  
Comprehensive Review ◽  
Nonalcoholic Fatty Liver ◽  
Mesh Terms ◽  
The Impact

ABSTRACT CONTEXT AND OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) has been increasingly diagnosed worldwide and is now recognized as a source of public health concern. It comprises a wide spectrum of histological features that range from simple steatosis to severe forms of fibrosis, steatohepatitis and even cirrhosis. The impact of bariatric surgery on the course of NAFLD in individuals with obesity has been extensively studied. DESIGN AND SETTING: Narrative review; public university hospital. METHODS: A comprehensive review was conducted based on an online search on the electronic databases MEDLINE and LILACS using the MeSH terms “fatty liver” and “bariatric surgery”. RESULTS: The exact mechanisms that lead to improvement in NAFLD following bariatric surgery are not completely understood. Since Roux-en-Y gastric bypass (RYGB) is the bariatric surgical procedure most performed worldwide, it is also the one from which the effects on NAFLD have been most studied, although there is also consistent evidence regarding the effects from gastric banding, sleeve gastrectomy and biliopancreatic diversions. CONCLUSION: According to the currently available evidence, bariatric surgery leads to significant improvement in NAFLD. Further research, especially by means of randomized controlled trials enrolling larger cohorts of individuals, is needed to determine the optimal procedure for this group of subjects.

scholarly journals New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis

2020 ◽  
Vol 72 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Natalia Pydyn ◽  
Katarzyna Miękus ◽  
Jolanta Jura ◽  
Jerzy Kotlinowski
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Fatty Liver Disease ◽  
Therapeutic Agents ◽  
Global Burden ◽  
Future Perspectives ◽  
Nonalcoholic Fatty Liver ◽  
Beneficial Effects

AbstractThe prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Globally, it is currently the most common liver disease and is estimated to affect up to 25% of the population. In the first stage, NAFLD is characterized by simple hepatic steatosis (NAFL, nonalcoholic fatty liver) that might progress to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis or hepatocellular carcinoma. In this review, we discuss the global burden of NAFLD, together with future perspectives on how this epidemic could be restrained. There is also an urgent need for the development of new medical strategies for NAFLD patients. We aim to present the beneficial effects of life-style modifications that should be advised to both non-obese and obese NAFLD patients. Since there are currently no medications directly used for the treatment of more advanced NAFLD stages, the central part of this review summarizes ongoing and recently completed clinical trials testing promising drugs for NASH resolution. The marketing of new therapeutic agents would greatly increase the odds of reducing the global burden of NAFLD.

Pediatric Nonalcoholic Fatty Liver Disease: A Comprehensive Review

2010 ◽  
Vol 57 (1) ◽  
pp. 85-140 ◽  
Author(s):  
Sarah M. Lindbäck ◽  
Charles Gabbert ◽  
Benjamin L. Johnson ◽  
Emmanuil Smorodinsky ◽  
Claude B. Sirlin ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Comprehensive Review ◽  
Nonalcoholic Fatty Liver

Beneficial Effects of Insect Extracts on Nonalcoholic Fatty Liver Disease

2020 ◽  
Vol 23 (7) ◽  
pp. 760-771
Author(s):  
Joo Young Lee ◽  
A-Rang Im ◽  
Ki Shuk Shim ◽  
Kon-Young Ji ◽  
Ki Mo Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Beneficial Effects

scholarly journals Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

2020 ◽  
Vol 117 (13) ◽  
pp. 7347-7354 ◽  
Author(s):  
Panu K. Luukkonen ◽  
Sylvie Dufour ◽  
Kun Lyu ◽  
Xian-Man Zhang ◽  
Antti Hakkarainen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Ketogenic Diet ◽  
Fatty Liver Disease ◽  
Redox State ◽  
Hepatic Insulin Resistance ◽  
Nonalcoholic Fatty Liver

Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite increasing circulating nonesterified fatty acids (NEFA), the main substrate for synthesis of intrahepatic triglycerides (IHTG). To explore the underlying mechanism, we quantified hepatic mitochondrial fluxes and their regulators in humans by using positional isotopomer NMR tracer analysis. Ten overweight/obese subjects received stable isotope infusions of: [D7]glucose, [13C4]β-hydroxybutyrate and [3-13C]lactate before and after a 6-d KD. IHTG was determined by proton magnetic resonance spectroscopy (1H-MRS). The KD diet decreased IHTG by 31% in the face of a 3% decrease in body weight and decreased hepatic insulin resistance (−58%) despite an increase in NEFA concentrations (+35%). These changes were attributed to increased net hydrolysis of IHTG and partitioning of the resulting fatty acids toward ketogenesis (+232%) due to reductions in serum insulin concentrations (−53%) and hepatic citrate synthase flux (−38%), respectively. The former was attributed to decreased hepatic insulin resistance and the latter to increased hepatic mitochondrial redox state (+167%) and decreased plasma leptin (−45%) and triiodothyronine (−21%) concentrations. These data demonstrate heretofore undescribed adaptations underlying the reversal of NAFLD by KD: That is, markedly altered hepatic mitochondrial fluxes and redox state to promote ketogenesis rather than synthesis of IHTG.

The Effect of a Low-Carbohydrate, Ketogenic Diet on Nonalcoholic Fatty Liver Disease: A Pilot Study

2007 ◽  
Vol 52 (2) ◽  
pp. 589-593 ◽  
Author(s):  
David Tendler ◽  
Sauyu Lin ◽  
William S. Yancy ◽  
John Mavropoulos ◽  
Pam Sylvestre ◽  
...  
Keyword(s):  
Liver Disease ◽  
Pilot Study ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Ketogenic Diet ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Low Carbohydrate
Sign in / Sign up

Export Citation Format

Share Document