Gain‐of‐function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta‐analysis

2018 ◽  
Vol 20 (1) ◽  
pp. 13-21 ◽  
Author(s):  
A. Qasim ◽  
A. J. Mayhew ◽  
S. Ehtesham ◽  
A. Alyass ◽  
A.‐L. Volckmar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Gain Of Function ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene

Antidepressants in short-term treatment of binge eating disorder: Systematic review and meta-analysis

2008 ◽  
Vol 9 (2) ◽  
pp. 129-136 ◽  
Author(s):  
Sérgio Carlos Stefano ◽  
Josué Bacaltchuk ◽  
Sérgio Luís Blay ◽  
José Carlos Appolinário
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Meta Analysis ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment

scholarly journals Scrutinizing Domains of Executive Function in Binge Eating Disorder: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Maria Elisa Gisbert Cury ◽  
Arthur Berberian ◽  
Bruno Sini Scarpato ◽  
Jess Kerr-Gaffney ◽  
Flavia H. Santos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Executive Function ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Meta Analysis

scholarly journals Dialectical Behaviour Therapy Improves Emotion Dysregulation Mainly in Binge Eating Disorder and Bulimia Nervosa: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 (9) ◽  
pp. 931
Author(s):  
Natalia Rozakou-Soumalia ◽  
Ştefana Dârvariu ◽  
Jan Magnus Sjögren
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Bulimia Nervosa ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Emotion Dysregulation ◽  
Meta Analysis ◽  
Control Group ◽  
Behaviour Therapy ◽  
Dialectical Behaviour Therapy

Emotion dysregulation is a transdiagnostic phenomenon in Eating Disorders (ED), and Dialectical Behaviour Therapy (DBT) (which was developed for reducing dysregulated emotions in personality disorders) has been employed in patients with ED. This systematic review and meta-analysis investigated whether the effect of DBT was stronger on emotion dysregulation, general psychopathology, and Body Mass Index (BMI) in participants with ED, when compared to a control group (active therapy and waitlist). Eleven studies were identified in a systematic search in accordance with PRISMA guidelines. Most studies included participants with Binge Eating Disorder (BED) (n = 8), some with Bulimia Nervosa (BN) (n = 3), and only one with Anorexia Nervosa (AN). The pooled effect of DBT indicated a greater improvement in Emotion Regulation (ER) (g = −0.69, p = 0.01), depressive symptoms (g = −0.33, p < 0.00001), ED psychopathology (MD = −0.90, p = 0.005), Objective Binge Episodes (OBE) (MD = −0.27, p = 0.003), and BMI (MD = −1.93, p = 0.01) compared to the control group. No improvement was detected in eating ER following DBT (p = 0.41). DBT demonstrated greater efficacy compared with the control group in improving emotion dysregulation, ED psychopathology, and BMI in ED. The limitations included the small number of studies and high variability.

Efficacy and safety of topiramate in binge eating disorder: a systematic review and meta-analysis

CNS Spectrums ◽  
2020 ◽  
pp. 1-9 ◽  
Author(s):  
Mikail Nourredine ◽  
Lucie Jurek ◽  
Marine Auffret ◽  
Sylvain Iceta ◽  
Guillaume Grenet ◽  
...  
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Randomized Clinical Trials ◽  
Data Extraction ◽  
Meta Analysis ◽  
Random Effect ◽  
Efficacy And Safety ◽  
Mean Differences

Abstract Background. To assess the efficacy and safety of topiramate in treating binge eating disorder (BED), using a systematic review and meta-analysis of the available randomized clinical trials (RCTs). Methods. The RCTs assessing topiramate vs placebo with or without adjunctive psychotherapy in BED were reviewed using a systematic search in the PubMed, Web of Science, PsycINFO, Cochrane Database of Systematic Review, and ClinicalTrials.gov search Websites, from inception to November 2019. Main outcomes were the changes in binge frequency, quality of life, and weight, respectively. Effect estimates were pooled using random-effect models and presented as risk ratios (RRs) or mean differences (MDs) and their 95% confidence interval (95% CI). Data extraction was performed by two independent reviewers. Results. Three studies were eligible for inclusion, involving 528 BED patients. Topiramate was found to be significantly more efficacious than placebo in reducing: (a) the number of binge episodes per week (MD = −1.31; 95% CI = −2.58 to −0.03; I2 = 94%); (b) the number of binge days per week (MD = −0.98; 95% CI = −1.80 to −0.16; I2 = 94%); and (c) weight (MD = −4.91 kg; 95% CI = −6.42 to −3.41; I2 = 10%). However, participants in the topiramate groups withdrew significantly more frequently for safety reasons, relative to placebo participants (RR = 1.90; 95% CI = 1.13-3.18, I2 = 0%). Conclusions. Preliminary findings support a possible efficacy of topiramate for the treatment of BED, even if safety concerns could limit the practical use of this treatment in BED subjects.

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